[Susceptibility of the gastric mucosa to the damaging action of a bile salt in chronic chagasic rats].
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Animals↗
Biomedical subjects
S Zucoloto
Publications and source records attributed to S Zucoloto.
Proliferative activity of denture-induced fibrous inflammatory hyperplasia analyzed by proliferating cell nuclear antigen labeling index.
PURPOSE: Denture-induced fibrous inflammatory hyperplasia (FIH) occurs around the borders of an ill-fitting denture. There has been no report in the literature concerning epithelial proliferative activity in FIH. The purpose of this study was to observe the labeling of proliferating cell nuclear antigen (PCNA) and evaluate its clinicopathologic results. MATERIALS AND METHODS: The labeling index (LI) was assessed by using the PCNA, a nuclear protein synthesized mainly in the G1-S stages of the cell cycle that could be detected immunohistochemically by the monoclonal antibody PC10. The PCNA LI was assessed in FIH specimens, in clinically normal specimens 1 cm from the FIH margin (adjacent group), and in clinically normal specimens located at least 2 cm from the adjacent group; the last were considered the control group. RESULTS: The mean PCNA LI values in the basal, parabasal, and overall epithelial layers were similar in FIH and in the adjacent group and were significantly higher than in the control group. CONCLUSION: These data support the importance of the surgical treatment of FIH with wide excision (about 1 cm) since the clinically normal tissue around the lesion could be histologically altered.
Cell Division↗
Denture-induced fibrous inflammatory hyperplasia: a retrospective study in a school of dentistry.
PURPOSE: The aim of this study was to investigate the denture-induced fibrous inflammatory hyperplasia (FIH) that occurs around the borders of an ill-fitting denture, in relation to frequency of the lesion, age and sex distribution, length of denture use, and frequency of dysplasia. MATERIALS AND METHODS: A comprehensive review of FIH diagnosed in patients wearing dentures by the oral pathology diagnostic service at the University of São Paulo over 26 years (1971 to 1996) was undertaken, based on retrospective analysis of the oral histopathologic files. RESULTS: The frequency of FIH was 15% of the total number of pathologies diagnosed at the service of oral pathology in that period. The disorder occurred predominantly in the fifth and sixth decades of life and more often among females, at a proportion of 5:1. The frequency of FIH was higher for a length of denture use of between 1 and 10 years. Dysplasia was found in 4% of cases. CONCLUSION: The knowledge of some aspects of FIH, especially the possible histologic alteration of dysplasia, supports the importance of the diagnosis and treatment of the lesion and suggests that any excised tissue should be submitted to histopathologic evaluation. Education and regular review of patients who have worn dentures are essential if the development of FIH is to be prevented.
Adolescent↗
[Colon adenocarcinoma with neuroendocrine and squamous cell differentiation. A case report].
A tubular adenocarcinoma of the colon with solid area composed by small cells that was found by immunohistochemistry study using antibody to neuron-specific enolase (NSE) to possess neuroendocrine differentiation is related. In another areas of the tumor were visualized keratinizing squamous cells. The presence of neuro-endocrine and squamous cells features provide further evidence that neoplastic colonic cells have the capacity for multi-directional differentiation. The implications of this combination in relation to theories of tumor origin and differentiation and the prognostic significance of neuro-endocrine cells in malignant neoplasms of the gastrointestinal tract are discussed.
Adenocarcinoma↗
[Effect of phytohemagglutinins on cell proliferation of the small intestine epithelium of rats].
Twenty male rats, were divided into two groups of ten animals each: E group, which received solid diet containing 4% of phytohemagglutinin and P group iso-caloric par-fed control, which received the same diet but the phytohemagglutinin was inactivated by heat. Water was offered ad libitum to all groups. The animals were weighed every day and the consumption of diet and water was registered. In the fourteenth day of experiment, the animals were sacrificed and the fragments of jejunum and ileum were removed to morphokinetic study. The results showed that the hydric ingestion was the same in both groups, the body weight of the E group was significant smaller than P group, the villus cell population from the jejunum of the E group was statistically smaller than P group and the contrary happened with ileum samples, wherein the E group was statistically larger than P. The jejunum villus height from E group was similar with P group, but in the ileum of the E group was larger than P. The depth, the cell population and cell production rate of crypt of E group were larger than P, in the jejunum and in the ileum. In conclusion, these results in the present study supply evidence that the intake of the phytohemagglutinin provokes injury of jejunal mucosa, reducing the villus cell population and stimulating the crypt hyperplasia, developing local adaptation. This adaptative model is similar to the one that occurs in celic disease. This proximal lesion stimulate crypt-villus unit hyperplasia of the ileal epithelium, developing distal adaptation. These adaptations occurred in animals that ingested phytohemagglutinin, even though with multicarencial malnutrition.
Animals↗
[Experimental study of the effects of alarm stimuli in rats].
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Adrenal Medulla↗
[Alcoholic cardiomyopathy].
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Alcoholism↗
[Morphological study of the small intestine in rats with experimental zinc deficiency].
Rats were maintained 4 weeks on a zinc deficient diet from the time of weaning. A control group received the same basic diet supplemented with zinc. Zinc deficiency, was indicated by poor weight gain, diarrhea, exudative vesicular dermatitis around ears, eyes, nose and extremities, and lowering of blood zinc levels. The morphometric study of the small intestine showed: 1) decreased thickness of the intestinal wall and of the mucosa; 2) significant decrease of the mean villies length and of the mean crypt depth; 3) no alterations in the height of the enterocytes from the middle one third of the villis and in the number of Paneth cells; 4) a decreased mitotic index; 5) a diminished number of epithelial cells living the ville, and 6) a decreased population of intraepithelial lymphocytes, both in the proximal jejunum and distal ileum. These findings are compatible with an impairment of cell replication in the small intestine in experimental zinc deficiency in rats, and allow us to speculate that the diarrhea usually seen in states of zinc malnutrition, at least in part, could be dependent on these changes.
Acrodermatitis↗
Inflammatory fibroid polyp. Review of the literature.
Inflammatory fibroid polyp is a rare polypoid lesion of the gastrointestinal tract, histologically characterized by a mixture of proliferation of fibroblasts and small blood vessels, accompanying a marked eosinophilic infiltrate. The lesion largely affects adults and is more common in the antrum of the stomach, but have occasionally been reported in the small bowel and colon. Clinical symptoms are variable, depending on the location and size of the lesion. Although it is generally believed to represent a reactive, nonneoplastic condition, their histogenesis remains controversial. The pathological features, hypothesis about pathogenesis and etiology, ultrastructural and immunohistochemical findings are discussed in this review of the literature.
Adolescent↗
[Jejunal myenteric denervation induced by benzalkonium chloride].
The effects of benzalkonium chloride (BAC) on the number of myenteric neurons, muscle thickness and external perimeter after acute (until 10 days after BAC application) and chronic (30 and 60 days after BAC application) denervation of the proximal jejunum were determined in rats. There was a significant reduction in the number of myenteric neurons of all segments treated with BAC. The extent of denervation varied along the time, and it was reduced in the denervated segments of the chronic group in comparison with the acute group. This may be due to the neuroplasticity phenomenon appearing during the chronic phase. Myenteric denervation increased the thickness of the propria muscle layer, especially in the longitudinal muscle layer, suggesting a higher sensitivity of this layer to myenteric denervation.
Animals↗
[Gastrointestinal endocrine cells: brief history and main identification methods under light microscopy].
The gastrointestinal tract shows a wide spectrum of endocrine cells diffusely distributed along the mucosa, interspersed among the exocrine cells. These cells share several features such as the capacity to produce a series of peptides. Despite the development of digestive endocrinology, especially in the last decade and with respect to the biochemical knowledge and cellular localization of gastrointestinal regulatory peptides, their functional significance and their role in digestive phisiopathology remain partially unknown. This review represents a summary of the principal information about morphological and histochemical features, embryologic origin, historical data, methods of identification and types of endocrine cells, of gastrointestinal tract.
APUD Cells↗