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Biomedical subjects

S Zigman

Publications and source records attributed to S Zigman.

At least 91 records · Page 5Linked to original sources
PubMed1971

Eye lens color: formation and function.

Aromatic amino acids are photooxidized by near-ultraviolet light to colored products that are bound very tightly to protein amino groups. The resulting colored proteins absorb near-ultraviolet light more strongly and are rendered more hydrophobic than the untreated compounds, and they fluoresce at 440 nanometers when excited at 360 nanometers. Coloration in the lenses of diurnally active animals (including man) may be caused by this reaction, and senile cataracts may result. Such changes in many other proteins (as in the skin and retina) could lead to more serious consequences.

Aging↗
PubMedDate not supplied

The role of sunlight in human cataract formation.

This review summarizes and integrates new findings concerning the role of near-ultraviolet radiation, as is present in sunlight and common artificial light sources, in stimulating human and animal cataract formation. Epidemiological and basic research studies are summarized and critical statements concerning them are offered. Although certain questions still remain unanswered, the evidence that near-UV radiation does stimulate cataract formation is very strong. Avoidance of excessive exposure to near-ultraviolet light and the use of protective lenses that filter it out are suggested to prevent the enhancement of human cataract formation by near-UV light.

Animals↗