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Biomedical subjects

S Zhu

Publications and source records attributed to S Zhu.

At least 289 records · Page 16Linked to original sources
PubMed1995

[Clinicopathological features and surgical treatment of early gastric cancer].

We analyzed retrospectively the clinicopathological data obtained from 126 patients with early gastric cancer (EGC) to elucidate the relationship between pathological patterns and lymphatic metastasis and the criteria of selecting appropriate surgery. Lymph node metastasis was 3.1% (2/65) in mucosal and 16.4% (10/61) in submucosal tumors respectively (P < 0.05). 26 patients with tumors smaller than 10 mm had no lymphatic metastasis, and 100 patients with tumors larger than 10mm in size had 8% (8/100) n1 positive, 4% (4/100) n2 positive and 7% (7/100) lymphatic duct invasion (P < 0.05). The 5-year survival rate in patients with lymphatic metastasis (79%, 15/19) was significantly lower than that in patients without lymphatic metastasis (97.2%, 104/107) (P < 0.01). It seemed that the most important prognostic factor is whether the presence of lymphatic metastasis or not. Lymphadenectomy is expected to improve the survival rate in EGC. D2 procedure is generally recommended as a standard operation for EGC, especially for the submucosal or larger lesion. Anyhow, D1 operation is sufficient for mucosal or smaller cancer, and D3 is suitable only for EGC patients with multifoci, superficially spreading type and group 3 lymph node metastasis.

Adenocarcinoma↗
PubMed1995

[Effects of resuscitation with hypertonic sodium lactate dextran 70 on cardiac function in severely burned dogs].

This comparative study was performed to evaluate the effects of resuscitation of burn shock with hypertonic sodium lactate dextran 70(HLD solution: Na+250 mmol/L and 6% dextran 70) and lactate Ringer' solution on cardiac function, lipid peroxide and SOD activity of heart tissue. Dogs with 35% TBSA third degree burns received, one hour postburn, either HLD resuscitation (HLD group, n = 6) in the amount of 19.6 ml.kg-1/g hours, followed by LR 6 ml.kg-1/% TBSA, or LR resuscitation (LR group, n = 6) in the amount of 8 ml.kg-1/% TBSA LR solution. The results of this experiment showed that cardiac index (CI) of HLD group was much higher than that of LR group at 4, 8, 12, 24 hours postburn. The dp/dt max and-dp/dt max of HLD group were much higher than that of LR group at 12.24 hours postburn. Level of MDA in heart tissue of HLD group (1.74 +/- 0.28 10 mol/g heart tissue) was much lower than of LR group (3.23 +/- 0.56 10 mol/g heart tissue) at 24 hours postburn (P < 0.01). Meanwhile, SOD activity in heart tissue of HLD group (157.49 +/- 32.23 u/mg heart tissue) was much higher than that of LR group (46.88 +/- 16.28 u/mg heart tissue) (P < 0.01). These results suggested that HLD resuscitation might be beneficial in improving postburn cardiac function and attenuating postburn oxidant-induced lipid peroxidation in heart tissue not only by its "oxygen scavenger" effect, but also by its elevation of SOD activity of heart tissue.

Animals↗
PubMed1995

Changes of plasma dynorphin levels before and after percutaneous balloon mitral commissurotomy in patients with mitral stenosis.

Plasma dynorphin A1-13 levels were measured in 33 patients with mitral stenosis before and after percutaneous balloon mitral commissurotomy (PBMC). The results show that the basal levels of plasma dynorphin in blood from the antecubital vein in the patients were significantly higher than those in 31 healthy control subjects. The increase in circulating dynorphin closely correlated with the functional cardiac status and the presence of atrial fibrillation. Ten to fifteen minutes after PBMC, plasma dynorphin levels in blood from the femoral vein increased significantly. Seventy-two hours after the procedure, the levels of plasma dynorphin in blood from the antecubital vein had decreased significantly, but they did not decrease to the normal range. Plasma dynorphin levels in blood from the femoral vein were positively correlated with the mean left atrial pressure and the mean right atrial pressure before the first balloon inflation. Plasma dynorphin levels in blood from the antecubital vein were positively correlated with the heart rate and the mean transmitral pressure gradient, and negatively with the mitral valve area before and 72 hours after PBMC.

Adolescent↗
PubMed1995

[A role of oblique flashlight test in screening for primary angle closure glaucoma].

PURPOSE: To study the effect of oblique flashlight test in screening for primary angle closure glaucoma. METHOD: Two hundred adults over 50 years old were sampled randomly at Doumen county of Guangdong province in 1995. 390 eyes were measured by oblique flashlight test according to grading standard photos of oblique flashlight test. Other ocular examinations consisted of intraocular-pressure measurement with Schiotz tonometer, gonioscopy, and optic disc appearance. RESULTS: The result showed 25.2% of the examined eyes had the oblique flashlight grade < or = 2, and tended to be increasing with age (x2 = 8.597, P < 0.05) and in females (x2 = 14.89, P < 0.01). Based on temporal anterior chamber angle < or = 2 (Shaffer's grade), the obligue flashlight grade < or = 2 found that occludable angle sensitivity was 91.7%, specificity was 91.5%, and 8.16% of the eyes had primary closure angle glaucoma. No patient was found in oblique flashlight grades > or = 3. CONCLUSION: This study shows that oblique flashlight test conforms to screening test needs, and plays an important role in screening for primary closure angle glaucoma. We suggest that oblique flashlight grades < or = 2 as cutoff point of screening for occludable angle.

Aged↗
PubMed1995

[Clinical application of MRI in ophthalmic field].

PURPOSE: To investigate the application of MRI in ocular diseases and analysis the character of MRI-s parameters in these diseases. METHODS: MRI was applied among 68 patients with neurophthalmic disorders, orbits diseases, and intraocular lensions. RESULTS: The position (location) and feature of the lesions were diagnosed with clinical analysis. CONCLUSION: MRI possesses the special value in the differentiation diagnosis of neurophthalmic disease, orbit disordes and intraocular conditions.

Adolescent↗
PubMed1994

Postnatal anti-interferon-gamma treatment prevents pancreatic inflammation in transgenic mice with beta-cell expression of interferon-gamma.

beta-Cell-targeted expression of interferon-gamma (IFN-gamma) leads to pancreatitis and immune sensitization to beta-cells. This transgenic model is used to explore the possible role of locally produced IFN-gamma in loss of tolerance to beta-cell-specific antigens in insulin-dependent diabetes mellitus (IDDM). The aim of the present study was to test if postnatal treatment with antibodies against IFN-gamma could inhibit morphological changes in the IFN-gamma transgenic pancreas, even though the transgene is expressed during embryogenesis. Treatment with a monoclonal rat anti-mouse IFN-gamma antibody for 6 weeks, starting from 5 to 7 days of age, completely inhibited IFN-gamma-induced morphological changes in the pancreas, and only a modest inflammatory reaction emerged after prolonged treatment for 12 weeks. The lack of morphological changes may reflect the ability of nonterminally differentiated neonatal pancreatic cells to compensate for transgene-induced pathological alterations occurring in utero prior to the antibody treatment. We conclude that inflammation and altered pancreas morphology in the transgenic mice is the result of the biological actions of IFN-gamma and not by disrupted islet development due to transgene overexpression in the pancreatic beta-cells. Furthermore, our treatment schedule can serve as a model for future intervention studies in the transgenic mice, elaborating the role of IFN-gamma in localized inflammatory reactions, IDDM in particular.

Animals↗
PubMed1994

The relationship of dietary animal protein and electrolytes to blood pressure: a study on three Chinese populations.

The relationship of diet to blood pressure was studied in a total of 705 men and women aged 40-59 from three Chinese population samples having different mean blood pressure and dietary sodium and animal protein intake. Two groups were farmers from Shanxi in northern China, and Guangxi in southern China, and the third were fishermen from Zhejiang, eastern China. Three 24-hour dietary recalls were done for each participant. Serum and overnight urine amino acids were measured in random subsamples. Determination of electrolytes in three 24-hour urine specimens was done in an additional sample of 59 men in each population. Results of multiple or stepwise regression showed: 1) in the pooled group, individual intake of sodium was positively associated with systolic blood pressure; 2) when stratifying by median calcium intake, a positive association of dietary sodium or sodium/potassium was found only in the group with calcium intake lower than the median; 3) daily intake of animal protein, urinary sulphate and certain serum and urine amino acids formed from protein metabolism, were inversely associated with blood pressure.

Adult↗
PubMed1994

Relative estimates of combination weights, decision criteria, and internal noise based on correlation coefficients.

A means by which relative combination weights may be determined is described for a signal detection model in which the decision variable is a weighted linear combination of several independent, normally distributed random variables, Xi's. The first theorem presents the correlation between the binary response variables--signal versus no signal--and the component Xi. The second theorem presents a parallel result for the case that additive internal noise is present. Thus in psychophysical experiments, the relative combination weights may be obtained by correlating the observers' responses and the input random variables. Third, three numerical methods which allow the evaluation of the relative magnitude of the decision criterion and the variance of a hypothetical additive internal noise are considered.

Attention↗
PubMed1994

Diurnal blood pressure variation and dietary salt in spontaneously hypertensive rats.

We have previously reported that high dietary salt exposure significantly increases daytime mean arterial pressure in spontaneously hypertensive rats (SHR) but not in normotensive Wistar-Kyoto (WKY) controls. In the present study, we used a telemetry monitoring system to evaluate the effects of high dietary salt exposure on diurnal variation of mean arterial pressure and heart rate in SHR and WKY rats. After implantation of a radio frequency transducer, SHR and WKY rats were maintained on either high (8%) or basal (1%) salt diets. Hemodynamic values were then analyzed for diurnal variation with the use of a nonlinear data-fitting program. After 2 weeks of dietary exposure, high salt-fed SHR had significantly greater 24-hour mean arterial pressure (156 +/- 3 mmHg) than SHR receiving basal (135 +/- 2 mmHg) and WKY rats receiving high (100 +/- 2 mmHg) or basal (100 +/- 1 mmHg) salt diets. Rhythm analysis indicated significant increases in both daytime and nighttime mean arterial pressure during high salt exposure in SHR. In WKY rats, high salt exposure increased nighttime but not daytime mean arterial pressure, with no net effect on 24-hour mean arterial pressure. High dietary salt exposure significantly decreased heart rate in both SHR and WKY rats, and it did not significantly alter the pattern of diurnal blood pressure or heart rate variation. These results indicate that WKY rats manifest an acute sensitivity to salt ingestion but have compensatory mechanisms sufficient to prevent sustained increases in mean arterial pressure; such mechanisms are lacking in SHR.

Animals↗
PubMed1994

[An experimental study on cultivation of human trigeminal ganglionic cell in vitro and its sensitivity to infection of herpes simplex virus type 1].

We firstly report an experimental study on the sensitivity of primary cultural human trigeminal ganglionic cells infected by herpes simplex virus type 1 (HSV-1) in different time-points. The results indicate that the neuron of human trigeminal ganglia is the most sensitive cell type, the antigen of HSV-1 replicates rapidly within the cytoplasm and cell nucleus, the fibroblasts and glia cells are infected partly by the virus. Therefore, perhaps the neuron is the main harboring cell type.

Antigens, Viral↗
PubMed1994

Toxicity and toxicokinetics of MeISP in isolated rat hepatocytes.

Toxicity and toxicokinetics of a new organophosphorus insecticide, MeISP, in isolated rat hepatocytes were studied. It was found that at the final concentration of 1.5 mmol/L, MeISP can (1) result in an increase of leakage of intracellular enzymes, alanine amino-transferase (ALT), lactate dehydrogenase (LDH), beta-glucuronidase (beta-GDase) and acid phosphatase (AcP) to the medium in a dose-dependent fashion; (2) give rise to obvious plasma membrane blebbing; (3) rapidly deplete the intracellular GSH and (4) almost completely inhibit the protein synthesis and gluconeogenesis from sodium pyruvate. The kinetics study showed that at the final concentration of 15 mumol/L, MeISP is rapidly metabolized and this process fits the one-compartment model. The metabolism of MeISP in the hepatocytes with phenobarbital-induced microsomal enzymes is accelerated. These results indicate that (1) MeISP has obvious toxicity to isolated rat hepatocytes and isolated hepatocytes provide a suitable system to examine the toxic effects of xenobiotics at the cellular level and (2) MeISP is metabolized mainly by microsomal enzymes.

Animals↗
PubMed1994

[Supraglottic horizontal-vertical hemilaryngectomy].

During the years 1980 to 1989, 41 patients (36 men and 5 women) with squamous cell carcinoma of larynx had undergone the supraglottic horizontal-vertical hemilaryngectomy. The patients' age ranged from 43 to 67 years; 78% was aged from 50 to 59. Among 41 patients, 23 were at the Department of Head and Neck Surgery of Shanxi Tumor Hospital and the other 18 patients at the Department of ENT of Beijing Hospital. There were 70.7% (29 patients) in T3 and T4 and 43.9% (18 patients) in N1-3. The 3- and 5-year survival rates of the patients were 82.9% and 75.7% respectively. The 41 patients have acquired the function of speech and swallowing in different degree; 85.4% (35 patients) was extubated. In this article, the main procedure of the operation is described and the modified method during the operation dealing with the recurrence of the original carcinoma, the lymph node metastasis, aspiration of the food and raise the raising of of extubation.

Adult↗
PubMed1994

[Comparative study of single strand conformation polymorphism of 4.5S RNA gene in enterobacteria].

A recently developed technique, non-isotopic single strand conformation polymorphism analysis (PCR-SSCP), was applied to study the conserved feature of 4.5S RNA gene in enterobacteria. The 4.5S RNA gene was amplified by the polymerase chain reaction, using the template DNA extracted respectively from five strains of Escherichia coli and three strains of different genera in Enterobacteriaceae, i.e. Proteus vulgaris, Serratia marcescens and Enterobacter aerogenes. The PCR products were then carried out SSCP analysis. The experimental results showed that there seemed to be no detectable differences in the size and single strand conformation of 4.5S RNA genes from above strains, except the negative strand conformation of Enterobacter aerogenes. Thus it can be seen that the secondary structures of 4.5S RNA gene in enterobacteria are quite conservative.

Base Sequence↗