[Screening of newborn infants for hypothyroidism using the determination of thyrotropin in umbilical cord blood].
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Biomedical subjects
Publications and source records attributed to S Zabransky.
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This is a report on two 10-year-old girls with a decompensated autonomous adenoma of the thyroid gland. Both girls were clinically euthyroid. In one girl there was no response of the thyrotropic cells of the anterior pituitary lobe to TRH stimulation for a short time during the first postoperative weeks. The diagnostic and therapeutic procedure in the case of nodular transformations in the thyroid area is discussed.
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Report on a boy aged 6-1/2 years with pseudohypoparathyroidism. This is due to a genetic lack of PTH inducible adenocyclase. Even during vitamin D treatment renal camp formation by giving PTH extract cannot be stimulated, while in this situation. PTH shows a clearly phosphaturic effect. Whether this is due to a PTH potentiated vitamin D effect is discussed. The assay of camp in urine before and after stimulation with PTH extract has proved the most certain diagnostic criterion.
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In a group of 216 healthy children (age: 3 days-16 years) normal values of alpha-amylase in serum were found out (substrate: p-nitrophenyl-alpha, D-maltoheptaosid). Infants (age: 3-353 days) mostly showed lower catalytic concentrations than older children: alpha-amylase (25 degrees C) up to 30 U/L; alpha-amylase 37 degrees C): up to 60 U/L. But, the collective was too small (n = 30) to give any statistical statement, on the other hand biological and analytical deviations of catalytic concentrations were big. In children (n = 186; age: 1-16 years) the values were not dependent on sex or age. As normal range we propose for children aged 1-16 years alpha-amylase (25 degrees C): 20-110 U/L; alpha-amylase (37 degrees C): 40-200 U/L.