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Biomedical subjects

S Yurdakul

Publications and source records attributed to S Yurdakul.

At least 91 records · Page 5Linked to original sources
PubMed1983

The arthritis of Behçet's disease: a prospective study.

A prospective study of arthritis was performed in 47 patients with Behçet's disease followed up over a 47-month period (mean 19.25 months, SD 14.09). These patients had a total of 80 episodes of arthritis, which were analysed for joint distribution and symmetry, in 56 of which the duration could also be determined. Attacks were oligoarticular, affecting up to 4 joints per patient, 54 (68%) being monoarticular. Knees, ankles, and wrists were the most commonly involved joints. Involvement of spinal, shoulder, hip, and sacroiliac joints was rare. The arthritis was usually not deforming and subacute; 82% (46/56) of the attacks lasted for 2 months or less and 18% (10/56) for between 3 months and 4 years. The ESR was moderately elevated during the attacks. In 32 specimens the synovial fluid was inflammatory (cell count 14.7 +/- 10.1 x 10(9)/l), but in 19 (59%) a good mucin clot formed. Synovial biopsy in 12 patients revealed superficial ulceration, paucity of plasma cells, and in 5 instances lymphoid follicle formation.

Adolescent↗
PubMed1981

Behçet's disease: lack of correlation of clinical manifestations with HLA antigens.

It has been suggested that certain tissue types are associated with different clinical manifestations of Behçet's disease in Japan and England. Regional differences in the associations between HLA antigens and Behçet's disease have been established. We tissue type 119 patients with Behçet's disease in Istanbul and attempted to correlate various clinical manifestations with HLA antigens. The frequency of only one tissue antigen, HLA-B5, was found to be increased in these series. HLA-B5 was present in 94 of 119 patients (77%) compared to 89 of 268 controls (33%), P less than 0.0001, ARR = 6.79. Age of onset, sex, incidences of ocular disease, arthritis, thrombophlebitis and erythema nodosum did not show any positive or negative associations with any of the alleles tested.

Adult↗
PubMed1980

A case of Whipple's disease complicated by fatal hepatitis.

Whipple's disease was diagnosed in a 42-year-old woman by the histological examination of a mesenteric lymph node taken at laparotomy, and the electron microscopic examination of a peroral intestinal biopsy specimen. She responded well to tetracycline therapy, but succumbed to fatal hepatitis ten weeks after the diagnosis of Whipple's disease

Adult↗
PubMed1977

Pilocarpine administration by contact lens.

A previous investigation had indicated that pilocarpine delivered to the eye by means of a hydrophilic contact lens provided better control of the intraocular pressure over a longer period and with a smaller concentration of pilocarpine. To clarify the situation further, an animal experiment was undertaken with radioactive labelled pilocarpine. Three situations were compared: pilocarpine administered by a contact lens, by drops, and by subconjunctival injection. The results indicated that the contact lens gave a greater concentration of the pilocarpine in the iris and ciliary body than either the drops or the subconjunctival pilocarpine. A high concentration of pilocarpine was achieved in the conjunctiva with drop administration and was comparable to that of subconjunctival administration.

Animals↗
PubMedDate not supplied

Experimental tractional retinal detachment: an immunohistochemical study.

PURPOSE: This study investigated the pathogenesis of tractional retinal detachment associated with proliferative vitreoretinopathy in an experimental model, using immunohistochemical staining. METHODS: To produce tractional retinal detachment in rabbit eyes, homologous cultured fibroblasts obtained from the gluteal muscle fascia were injected intravitreously. Right eyes of 20 rabbits in the study group, and 7 rabbits in the control group were followed for 26 days at weekly intervals with indirect ophthalmoscopy and fundus photographs. RESULTS: During the follow-up period grade III tractional retinal detachment developed in 11 eyes, grade II in six, and grade 1 in three eyes. The spindle-shaped cells contributed predominantly to the development of epiretinal membrane, and a smaller number of round small and large cells. In 10/17 grade II and III eyes, spindle-shaped cells had vimentin, 7/10 had actin, 5/17 had GFAP, 4/17 had S-100 protein immunoreactivity. Round small and large cells expressed S-100 protein, GFAP and actin in 5/17 eyes. Epiretinal membrane appeared to be formed by spindle-shaped fibroblast-like cells and small and large round glia-like cells. Actin positivity of spindle-shaped and round cells was taken as a marker of contractile elements of the cells and their locomotional features. CONCLUSIONS: These features are believed to be involved in contraction of the membrane and retinal detachment.

Actins↗