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Biomedical subjects

S Yamazaki

Publications and source records attributed to S Yamazaki.

At least 613 records · Page 34Linked to original sources
PubMed1981

Resection of lung cancer involving the heart and great vessels.

Over the last six years at the Tokai University Hospital, 104 patients were operated on for the primary lung cancer. Twenty nine of these patients were submitted to extended operations, because cancer had invaded the heart and/or great vessels. In three cases, the left pneumonectomy with partial resection and suture repair of the descending thoracic aorta was performed. In 26 cases, intrapericardial ligation of the pulmonary vessels was carried out: nine of these patients underwent intrapericardial pneumonectomy with partial resection of the atrial wall and one patient underwent sleeve resection of the superior vena cava with graft (Gorétex) replacement. No extracorporeal apparatus was used in any cases of extended operations. The postoperative course was mostly uneventful and there were no cases of operative death. We believe that excision of lung cancer extending into the heart and great vessels can offer the patient every chance for a longer life, especially in the case of squamous cell carcinoma.

Adult↗
PubMed1980

Stereochemical studies of 8-hydroxy-5-deazaflavin-dependent NADP+ reductase from Methanococcus vannielii.

The purified 8-hydroxy-5-deazaflavin-dependent NADP+ reductase from Methanococcus vannielii catalyzes an oxidation-reduction reaction between a novel 8-hydroxy-5-deazaflavin cofactor and nicotinamide adenine dinucleotide phosphate. The reaction was shown to be a direct hydride transfer process. Using stereospecifically 3H-labeled substrates, the steric course of this process was established to be S-specific with respect to the nicotinamide nucleotide. The 8-hydroxy-5-deazaflavin-dependent NADP+ reductase from M. vannielii and the hydrogenase system in the cell-free extracts of Methanobacterium thermoautotrophicum recognize the same side, designated as A side, with respect to the prochiral center at C-5 of the dihydro-8-hydroxy-5-deazaflavin cofactor.

Euryarchaeota↗
PubMed1980

Purification and properties of 8-hydroxy-5-deazaflavin-dependent NADP+ reductase from Methanococcus vannielii.

The 8-hydroxy-5-deazaflavin-dependent NADP+ reductase component of the formate NADP+ oxidoreductase system of Methanococcus vannielii has been purified to homogeneity. The enzyme is specific for NADP+ and 8-hydroxy-5-deazaflavin. It catalyzes the reaction: 1,5-Dihydro-8-hydroxy-5-deazaflavin anion + NADP+ in equilibrium 8-hydroxy-5-deazaflavin + NADPH. The apparent molecular weight of the native enzyme is 85,000. A subunit molecular weight of 43,000 determined by sodium dodecyl sulfate gel electrophoresis indicates that the native enzyme is a dimer. The optimal temperature for catalytic activity is 17-20 degrees C and the pH maxima are 7.9 and 4.8 for the forward and reverse reactions, respectively. The kcat value of the forward reaction is 24 times greater than that of the reverse reaction, thus the production of NADPH at pH 7.0 is more favorable than its consumption. The reductase contains one or more sulfhydryl groups which are essential for catalytic activity.

Chemical Phenomena↗
PubMed1980

Catamenial pneumothorax associated with endometriosis of the diaphragm.

A case of catamenial pneumothorax is documented. At thoracotomy, there was a small black mass measuring 10 x 6 mm associated with surrounding petechiae on the top of the dome of the right diaphragm. Microscopic examination revealed the presence of endometrial tissue. We could not find any diaphragmatic defect in this case.

Adult↗