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Biomedical subjects

S Yachiku

Publications and source records attributed to S Yachiku.

At least 163 records · Page 9Linked to original sources
PubMed1983

[Effect of calcitonin on body pains caused by bone metastases of urogenital cancer].

Calcitonin obtained from eels (ell-CT) was given to 14 patients who had developed bony pains due to bone metastases of malignant tumors and who did not respond to 12 various analgesics. The patients consisted of 12 males and 2 females, with a mean age of sixty-five. Eel-CT (Elcitonin) was injected intramuscularly to each patient at a dose of 40 units twice daily. Other analgesics were assessed to be ineffective at the time of CT administration and they were not given consideration in the evaluation. For the assessment of drug effect, a pain score was prepared. Eel-CT was markedly effective in 3 patients, effective in 8 patients, and ineffective in 2 patients. Eel-CT had a better effect on prostatic cancer than any other cancer. The analgesic effect was observed in the first week of drug administration at around a total dose of 1,000 units. Although the pain tended to appear at regions on which the body weight was liable to rest, the analgesic effect was seen irrespective of the side of pain. Since serum calcium, phosphate, parathyroid hormone (PTH), CT levels and bone scintigrams between pre-and post-CT administration did not differ, the analgesic mode of action of CT is not supposed to be related to inhibition of bone absorption nor bone formation. The therapeutic effect hardly suggests any direct action of CT on the tumor.

Adenocarcinoma↗
PubMed1983

[Tissue polypeptide antigen (TPA) in urological malignancies. I. S-TPA in bladder cancer patients].

Serum tissue polypeptide antigen (S-TPA) levels in 22 patients with bladder cancer were determined using a radioimmunoassay kit by the two-antibody technique to evaluate the usefulness of this parameter as an index of the presence of cancer. As S-TPA values (mean +/- SD) in 72 Japanese normal blood donors (37 male and 35 female) were in the range of 32.4-97.2 units per liter, values higher than 97.2 u/l were considered positive. We found a remarkably increased level of S-TPA in 14 out of 18 (77.8%) patients with untreated cancer and a slightly increased level of S-TPA in 3 out of 4 patients whose tumors had been removed. Elevated S-TPA levels in patients who had tumors remaining were suggested to correlate with histological stage and grade of tumors, type of growth and size of tumors, although not to correlate with number of tumors and whether tumor occurrence was initial or recurrent. Simultaneous urinary cytological examination and measurement of plasma CEA in the same patients gave the positive ratio of 7/16 (43.8%) and 0/14 (0%), respectively. It is possible that S-TPA may be one of the most useful tumor markers in the screening of cancer, diagnosis of histological characteristics, monitoring of cancer therapy and detection of recurrence.

Female↗
PubMed1982

Neuro-pharmacologic studies on neurogenic bladder after radical hysterectomy.

Miction function of patients who had had radical hysterectomy was investigated neuro-pharmacologically. The patients were divided into two groups according to the operation, with or without preservation of the plexus pelvicus, and bladder and urethral functions were compared by the bethanechol test and phentolamine test. The group with transected plexus pelvicus showed neurogenic bladder with impairment of functions of parasympathetic and sympathetic nerves and the preserved group showed much less impairment in functions of both nerves.

Adult↗
PubMed1982

Urethral pressure profiles following radical hysterectomy.

Urethral function following radical hysterectomy was studied by chronologic analysis of the urethral pressure profile. Thirty patients who had radical hysterectomy were divided into 2 groups according to the degree of preservation of the plexus pelvicus at operation. The method of complete preservation is described. Urethral pressure profiles showed a significant postoperative decrease of mean maximum urethral closure pressure in the group of 20 patients with bilateral nerve transection; this was not found in the group of 10 patients with complete preservation of the plexus pelvicus. The decrease was ascribed to possible damage of sympathetic nerves originating from the hypogastric nerve. The results indicated that postoperative abnormalities in urination are caused by damage not only to the parasympathetic nerves (the pelvis nerve) but to the sympathetic nerves (the hypogastric nerve) as well.

Female↗
PubMed1981

Ultrasonic evaluation of prostatic carcinoma.

Twenty-four patients with prostatic carcinoma were examined by transrectal ultrasonotomography. Ultrasound could differentiate prostatic cancer from other prostatic diseases. Since ultrasonic diagnosis is noninvasive, safe, and painless, repeated examinations could be performed, and it was useful to follow patients with prostatic carcinoma after treatment.

Biopsy↗
PubMed1981

[The influence on the urinary tract function after modified radical hysterectomy (author's transl)].

Total urodynamics tests, subjective complaints and intravenous pyelographic findings were investigated in order to clarify the condition of urinary tract after modified radical hysterectomy, comparing with radical hysterectomy with complete preservation of the plexus pelvics. The following results were obtained. 1) No subjective complaints of urination were obtained at three months after the operation. 2) The cystometrograms and the urethral profile pressure patterns after the operation were same as the preoperative patterns. 3) The urinary flow curves revealed normal patterns except one case. 4) In I.V.P. findings, considerable transient disturbances were noted on the upper urinary tract in 15.8%. 5) The patients with radical hysterectomy of complete preservation of the plexus pelvics remained direct operative disturbance at three months and from any view points we investigated the radical hysterectomy, even with complete preservation of the plexus pelvics remained worse influence in patients than modified radical hysterectomy.

Female↗
PubMed1980

Retrovesical chondrosarcoma.

Retrovesical sarcoma is rare. We report the first documented case of retrovesical chondrosarcoma. The patient underwent pelvic evisceration with creation of anileocecal conduit and colostomy. There have been no signs of local recurrence or metastasis.

Chondrosarcoma↗
PubMed1980

Serum-ionized calcium as a diagnostic tool in hypercalciuria.

Serum-ionized calcium (Ca++) was measured in 65 patients with idiopathic calcium urolithiasis. The patients were then divided into hypercalciuric and normocalciuric groups based on the mean + SD of the control group, with greater than 180 mg/24 h in males and greater than 176 mg/24 h in females defined as hypercalciuria. The results showed a decrease in the tubular reabsorption of calcium in the hypercalciuric group, but not in the normocalciuric group. The hypercalciuric group was then further divided into group I with increased filtered load and group II with with normal filtered load. It was suggested that the group I hypercalciurics had absorptive hypercalciuria and group II renal hypercalciuria.

Adult↗
PubMed1980

Bladder neck dysfunction: the effect of the alpha-adrenergic blocking agent phentolamine on bladder neck dysfunction and a fluorescent histochemical study of bladder neck smooth muscle.

Urodynamic examinations and fluorescent histochemical studies suggest that patients with bladder neck obstruction can be divided into two main groups (responders and nonresponders) based on the response of their urinary flow rate to phentolamine and that the adrenergic nervous system of the bladder neck has an important effect on the response in responders.

Adrenergic Fibers↗