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Biomedical subjects

S Woyke

Publications and source records attributed to S Woyke.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Atypical lipoma as a potential pitfall in the cytodiagnosis of subcutaneous tumors. A report of two cases.

BACKGROUND: If well-differentiated liposarcomas of lipomalike type occur in the subcutis, they behave as benign neoplasms. For these tumors the term atypical lipoma was introduced in 1975. Fine needle aspiration (FNA) findings in these tumors may raise a false impression of malignancy. CASES: Females aged 34 and 48 years presented with well-defined subcutaneous nodules in the left supraclavicular region and on top of the head, respectively. FNA showed fragments of mature fat tissue and numerous dispersed, large, hyperchromatic, often bizarre nuclei. Lipoma with atypical cells was diagnosed cytologically in one case and atypical lipoma in the other. Histologically both cases were evaluated as atypical lipoma. CONCLUSION: A correct cytologic diagnosis of atypical lipoma can be established if cytomorphologic features are coupled with clinical data.

Adipocytes↗
PubMedDate not supplied

Cytodiagnosis of acinic cell carcinoma. Ultrastructural study of material obtained by fine needle aspiration biopsy.

The material obtained by fine needle aspiration biopsy from a metastatic acinic cell carcinoma was evaluated by light and electron microscopy. A preliminary diagnosis of acinic cell carcinoma established by light microscopy was confirmed by electron microscopic study. Glandular arrangement of cancerous cells and the presence of a specific type of secretory granules in their cytoplasm were the most characteristic ultrastructural features of the acinic cell carcinoma.

Biopsy, Needle↗
PubMedDate not supplied

Transmission and scanning electron microscopic studies of cells in effusions.

The transmission (TEM) and scanning electron microscopic (SEM) features of cancer cells and benign cells from human effusions were described. Both in the TEM and the SEM the following cell types were indentified; mesothelial cells, histiocytes, lumphocytes, eosinophilic leukocytes, neutrophilic leukocytes, plasma cells, erthrocytes and cancer cells. The ultrastructure of malignant cells originating from cancers most commonly metastisizing to the serous body cavities was described in detail. Both the TEM and the SEM clearly demonstrated fundamental differences between the surfaces of the cancer cells and benign cells in body cavity fluids: cancer cells were covered by numerous microvilli, while non-neoplastic cells were not. The approach described in this paper can be used for purposes of cytologic diagnosis in difficult preselected cases and may also have some important theoretical implications.

Adenocarcinoma↗
PubMedDate not supplied

Fine needle aspiration cytology of rare malignant tumors of the breast.

This report describes the fine needle aspiration (FNA) cytologic findings in 17 rare malignant breast tumors. The series consisted of invasive cribriform carcinoma, papillary carcinoma, apocrine carcinoma, carcinoma with pseudosarcomatous metaplasia, carcinosarcoma, fibrosarcoma, malignant phyllodes tumors, primary malignant lymphomas, plasmocytoma, metastatic melanoma and metastatic renal clear cell carcinoma. Besides cytomorphology, the results of immunostaining in eight cases are presented, as is a review of the literature. It is important for rare primary malignancies, as well as for metastatic tumors, to be diagnosed, or at least have the diagnosis suggested, preoperatively by FNA and immunocytochemistry, permitting better therapy planning.

Adenocarcinoma↗
PubMedDate not supplied

Endoscopic brushing cytology of primary gastric choriocarcinoma. A case report.

A rare primary choriocarcinoma of the stomach developed in a 71-year-old woman admitted with epigastric pain and weight loss. Brushing smears revealed highly atypical malignant cells with bizarre nuclei and prominent nucleoli. Multiple histologic sections revealed pure choriocarcinoma. Human chorionic gonadotropin and keratin were demonstrated in malignant cells by immunohistochemistry.

Aged↗
PubMedDate not supplied

The surface coat of the human effusion cells.

Cancer cells of human effusions have a prominent surface coat clearly demonstrated by ruthenium red staining. The cancer cells forming clumps are usually interconnected with each other by gap junctions which is expressed by a free penetration of the ruthenium red through the majority of the junctions. The benign cells encountered in human effusions are also covered with the surface coat, which, however, is usually thinner in comparison to the coat observed on the cancer cells.

Adenocarcinoma↗
PubMedDate not supplied

The morphology of cells in effusions settled on glass.

The cells of human body cavity fluids were examined by light microscopy and with a scanning electron microscope after settling on the surface of glass. Some differences in behavior of various cell types were noticed. The histiocytes, a few minutes after settling, began to spread, and thin processes later extended from their cytoplasm. Extension of mesothelial cells was observed a few hours after settling, and was not proceeded by flattening. The flattening of neutrophils occurred soon after settling, and was not followed by extension. The other cells encountered in effusion, both benign and malignant, did not change their shape even up to 12 hours after the time of settling. The differences in behavior after the settling of various cell types encountered in human effusions is discussed in relation to their biological properties.

Ascitic Fluid↗
PubMedDate not supplied

Decisive role of intermediate filament typing of tumor cells in the differential diagnosis of difficult fine needle aspirates.

Thirty-six diagnostically difficult fine needle aspirates from enlarged lymph nodes and malignant soft tissue tumors, containing tumor cells with scanty or no obvious light microscopic features indicative of their differentiation, were assessed by a panel of six cytopathologists. Their diagnoses were recorded and then compared with the definitive diagnosis established by combining the cytologic findings with the results of intermediate filament typing of tumor cells in the smears using monoclonal antibodies specific for each filament type. The results show that use of these antibodies can markedly improve the accuracy of the cytologic diagnosis of tumor type as well as revise or prevent erroneous cytologic diagnoses in difficult cases. This pertains especially to the differential diagnoses of carcinoma versus malignant lymphoma, carcinoma versus malignant melanoma, carcinoma versus sarcoma and squamous carcinoma versus carcinoma of simple epithelia. Intermediate filament typing of tumor cells in aspirates as an objective histogenetic criterium makes the differential diagnosis of the difficult aspirates much more reliable and reproducible, provided that appropriate questions are asked, monoclonal antibodies with well-defined specificities are used and the antigenicity of the intermediate filaments in smears is preserved.

Adult↗