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Biomedical subjects

S Workman

Publications and source records attributed to S Workman.

27 records · Page 2Linked to original sources
PubMed1983

Anti-intercellular substance antibodies. Presence in serum samples of 14 patients without pemphigus.

Fourteen of 1,500 patients whose serum samples were evaluated by indirect immunofluorescence microscopy had demonstrable titers of anti-intercellular substance (ICS) antibodies in the absence of clinical or histologic evidence of pemphigus. The anti-ICS antibodies were absorbed by A and B blood group antigens in nine of the 14 patients. In five patients, the titers of anti-ICS antibodies were unchanged after absorption with blood group substances. All five of these patients had cicatricial or bullous pemphigoid on clinical, histologic, and immunopathologic examination. Clinical pemphigus did not develop in any of the 14 patients on follow-up examinations conducted for three to 18 months. It seems that anti-ICS antibodies can be produced in several clinical conditions in which there is damage to the epidermis. These anti-ICS antibodies may not have any pathogenetic activity in vivo, at least within the time limits defined by our follow-up examinations.

ABO Blood-Group System↗
PubMedDate not supplied

Accuracy of clinical impressions and Mini-Mental State Exam scores for assessing capacity to consent to major medical treatment. Comparison with criterion-standard psychiatric assessments.

The authors evaluated the accuracy of clinical impressions and Mini-Mental State Exam scores for assessing patient capacity to consent to major medical treatment, relative to expert psychiatric assessment. Consecutive medical inpatients (N = 63) facing a decision about major medical treatment received a clinical impression of capacity from their treating physician and the Standardized Mini-Mental State Exam (SMMSE); 48 received independent psychiatric assessment of capacity. Analyses revealed that both clinical impressions and SMMSE scores were generally inaccurate in determining capacity, although all 23 participants with a clinical impression of "definitely capable" were found capable by the psychiatrist. Given the importance of assessing capacity to consent to major medical treatment, better approaches to the clinical assessment of capacity are required. Several strategies are discussed.

Adult↗