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Biomedical subjects

S Wolfson

Publications and source records attributed to S Wolfson.

70 records · Page 4Linked to original sources
PubMedDate not supplied

The eustachian tube midportion in infants.

The eustachian tube midportion in infants and children was measured in 44 eustachian tubes from normal temporal bones and 11 eustachian tubes from temporal bones harboring acute otitis media. The temporal bones were serially sectioned, and the lumina of the eustachian tubes' midportions were measured with the aid of a grid mounted on a microscope. These measurements showed that the eustachian tube lumen grows to a small degree with age. Each age group showed a considerable variation in the range of the luminal area compatible with natural biologic distribution. No statistically significant difference was found in the sizes of the midportions of the eustachian tube lumina from temporal bones that harbored acute otitis media when compared with the lumina of the eustachian tube midportions from normal ears.

Acute Disease↗
PubMedDate not supplied

The human Eustachian tube lumen in children. I. The isthmus.

A study of Eustachian tube measurement in infants and children is presented. The study comprised 53 Eustachian tubes from normal temporal bones and 17 Eustachian tubes from temporal bones harbouring acute and secretory otitis media. The temporal bones underwent histologic serial sectioning. The lumen of the Eustachian tube isthmus was measured with the aid of a grid mounted on a microscope. These measurements show: A) the Eustachian tube isthmus lumen does grow and enlarge slightly with age; B) each age group presents a considerable range in area, compatible with a natural biological distribution; C) no statistical difference was found in the size of isthmus lumens obtained from temporal bones which had been affected by acute or secretory otitis media, when compared with lumens of Eustachian tubes coming from non-pathological ears. This comparison took into consideration both age and physiological distribution.

Age Factors↗
PubMedDate not supplied

Acute cardiac failure and hepatic ischemia induced by disopyramide phosphate.

Two patients abruptly developed congestive heart failure and elevation in serum transaminase levels when given disopyramide phosphate; enzyme abnormalities and hemodynamic status corrected upon withdrawal of the drug. Both patients had underlying ischemic cardiomyopathy. Myocardial infarction, pulmonary embolism, and viral hepatitis were ruled out in both patients. One patient had a liver biopsy documenting central hepatic necrosis with congestion, consistent with hepatic ischemia and not toxic hepatitis. In the other patient, cardiac decompensation and hepatocellular enzyme elevation were reproduced on rechallenge with the drug. Disopyramide should be used with caution in patients with heart failure.

Acute Disease↗
PubMedDate not supplied

Ammonia transport across hydrophobic membranes. Application to dialysate regeneration.

Removal of ammonia from a recirculating dialysate buffer in a portable hemodialysis application can be achieved by countercurrent, gas phase ammonia transfer across a hydrophobic membrane into an acid solution. Ammonia transfer fluxes as high as 0.076 mumol/sec/m2 have been achieved using a Sarns Turbo Membrane Oxygenator (Sarns-3M, Ann Arbor, MI) with a 1.9 m2 membrane surface area (0.145 mumol/sec actual rate). A simple physical model based upon ammonia desorption at the gas-dialysate buffer interface in a membrane pore, ammonia diffusion through the gas filled pore, and subsequent ammonia absorption at the gas/acid interface side of the pore quantitatively describes the experimental data. The ammonia transfer rate is most dependent upon dialysate buffer pH (higher pH promoting transfer rate) and ammonia concentration in the dialysate buffer (higher concentrations promoting transfer rate). A 500 fold improvement in transfer rate, however, will be required for clinical application.

Absorption↗