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Biomedical subjects

S Witchitz

Publications and source records attributed to S Witchitz.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

[Reconstructive surgery in arterial disease of the legs at the stage of intermittent claudication. Report of 100 cases (author's transl)].

100 patients with stage II arteritis (claudication alone) were operated on. In the vast majority of cases (78%), the lesions were aorto-iliac. The operative mortality was nil. The immediate follow up period included 2 thromboses requiring 2 reoperations. The long term follow up, on average 22 months (from 8 months to 3 years) was very satisfactory with a good functional result in 94.5% of cases. We noted 4 deaths, of which 3 were of cardiovascular origin, 4 secondary thromboses of which 2 were due to suddenly stopping anticoagulants. The low morbidity is a further reason for early surgery, as it is known that the risks of operation at a later stage, e.g. stages III and IV, may occur suddenly in the course of an apparently stable arteritis.

Adult↗
PubMedDate not supplied

[Diuretics, potassium depletion and ventricular hyperexcitability].

This prospective randomized study involved 28 patients with moderate essential hypertension who for one year, took either hydrochlorothiazide [Esidrex (E) 25-50 mg per day] or a combination of altizide 15 mg--aldactone 25 mg [Aldactazine (A) 1 or 2 tablets per day] without potassium supplements. Blood pressure, plasma potassium, exchangeable potassium, ventricular premature contractions measured by Holter and plasma magnesium were monitored. Blood pressure was brought to normal in both treatment groups (p < 0.001). Plasma potassium fell by 0.19 mmol/l with A (NS) and 0.35 mmol/l (p < 0.01) with E. Changes in potassium pool were not significant. There was a non-significant reduction in the number of ventricular premature contractions in both groups. There was no correlation between the few cases of frank hypokaliema, fall in potassium pool and complex ventricular premature contractions. A review of the literature offers no solid arguments suggestive of significant potassium risk associated with these diuretics. Any such risk can be eliminated by the use of low doses, combined if necessary with a potassium-sparer or a hypotensive agent of another group.

Adult↗