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Biomedical subjects

S Whitehouse

Publications and source records attributed to S Whitehouse.

42 records · Page 3Linked to original sources

Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate (Short Communication).

The activity of pyruvate dehydrogenase was assayed in extracts of rat hearts perfused in vitro with media containing glucose and insulin+/-acetate+/-dichloroacetate. Dichloroacetate (100mum, 1mm or 10mm) increased the activity of pyruvate dehydrogenase in perfusions with glucose or glucose+acetate. Evidence is given that dichloroacetate may facilitate the conversion of pyruvate dehydrogenase from an inactive (phosphorylated) form into an active (dephosphorylated) form.

Journal Article↗

The effect of age on glucose tolerance: studies in the Polynesian population of Funafuti.

Venous plasma glucose concentrations both fasting and 2 h after a 75 g carboydrate load were determined in 577 Polynesian subjects. An increase in both the mean fasting and postload glucose concentrations with age was noted in both sexes. Percentile distributions of both fasting and post-load glucose concentrations showed there was little change with age in males except for the 90th percentile. However, in females there was a rise with age in all percentiles, but it was most dramatic in the 90th. The overall prevalence of diabetes in the females of this Polynesian population is three times that of the males, and the age and sex-specific rates are much higher in the females. It appears, therefore, that the major contribution to the age-related rise in glucose concentrations reported here is the increasing number of diabetics (mainly female) with age.

Adolescent↗

The high incidence of diabetes mellitus in the micronesian population of Nauru.

As a follow-up to surveys conducted three years ago among the Micronesian population of Nauru, the incidence and prevalence of diabetes mellitus was studied in 433 subjects aged 20 years and older. The diagnosis of diabetes was based on a 2-h plasma glucose of 200 mg/dl (11.1 mmol/l), enabling comparison with the Rochester, U.S.A., (Caucasian) and Pima (American Indian) studies. In both sexes the prevalence rate rose steadily with age, and the overall prevalence was 24% for both sexes. The overall incidence rate was 15.4 per 1,000 person-years. However, males had almost twice the incidence of the females (20.2% vs 11.5%). The incidence rate of diabetes in Nauruans was considerably higher than that found in Rochester and was second to that of the Pimas as the highest rate reported in the literature.

Adult↗

An unanticipated increase in patient visits to a pediatric emergency department.

This study was conducted to explain a more than threefold increase in anticipated patient visits associated with the opening of a separate pediatric emergency department (PED) 2 miles from the nearest general emergency department. Population demographics and data pertaining to visits to other emergency departments were obtained. Parents visiting the new PED were surveyed using a standardized questionnaire. Over the study period (1984-1989), the city population increased by 7%; school population increased by 17%, with no increase in birth rate. Total patient visits to the other city hospitals increased by less than 10%, while the number of visits to the PED increased 250% over anticipated visits. Of children visiting the PED, 48% were less than 5 years old, 30% had lived at their current address less than 2 years, and 80% came from the geographic area close to the PED. Parental decision to bring the child to the PED was as follows: a service perceived to be "for kids" (47%), previous visit (42%), closest facility (33%), better service (20%), referred (12%), and pediatrician availability (10%). The PED is staffed by licensed pediatricians, whereas the general emergency departments are staffed by emergency physicians. We conclude that the increase in visits cannot be accounted for by increases in regional population base only. Anticipated patient volume to a new health care facility should not be based on population demographics only, but on other factors such as user perception of facility. Patient or parent preference should also be considered.

Birth Rate↗

Nutrient intake in a partly westernized isolated Polynesian population: the Funafuti survey.

Dietary data were obtained from 110 adult Polynesians (indigenous Funafutians) during a diabetes epidemiologic survey in Tuvalu. Funafuti (the main island of Tuvalu) was chosen as representative of partly urbanized population that has seen progressive socioeconomic changes in the previous 30 yr. The distribution of calories in the Funafuti diet is almost identical to that reported in the urbanized Micronesian population of Nauru and in Caucasian populations. Prevalence of diabetes was found to be five times higher than that reported in caucasian populations. Similarly, the prevalence of hypertension was 11% (equal to Caucasian figures), whereas hypertension is virtually unknown in traditional-living populations. Prevalence of diabetes, and degree of obesity, is significantly greater in women than in men. It is possible that this Polynesian group may have a genetic susceptibility to diabetes, which may have been unmasked by change from a traditional to western life-style. Marked obesity is now a characteristic of many Polynesian and Micronesian populations, and must rank as a major causative factor for the diabetes and hypertension explosion.

Adult↗