Biomedical subjects

S Wen

Publications and source records attributed to S Wen.

79 records · Page 5Linked to original sources

PubMed1979

Synchronization of estrus in beef heifers with a norgestomet implant and prostaglandin F2alpha.

In a 5-year study (1973-1977), 281 cycling beef heifers were treated with a 7-day norgestomet (SC21009) ear implant and an intramuscular injection of prostaglandin F(2alpha) (PGF(2alpha)) at the time of implant removal or 24 hr before implant removal. Percentages of heifers in estrus by 36, 48, 60, 72, and 120 hr after implant removal were 32.4, 52.7, 71.6, 80.1, and 93.2, respectively. Onset of estrus occurred an average of 49.8 +/- 4.7 hr after treatment. Percentages of heifers in estrus 36 hr after treatment were 5.7 and 51.7 for those with a corpus luteum and those without a corpus luteum (or determined regressing by palpation) at implant removal, respectively. When PGF(2alpha) was injected 24 hr before implant removal, 55% of the heifers were in estrus by 36 hr after implant removal compared to 30% when PGF(2alpha) was injected at the time of implant removal; however, by 60 hr after implant removal the difference was 76% vs. 71%. First-service conception rates for synchronized and nonsynchronized heifers were 62.2% and 59.6%, respectively. During 1976 and 1977 heifers were checked for estrus every 4 hr and inseminated 2, 6, 10, 14, 18, 22, 26, or 30 hr after first detected to be in standing estrus. Conception rate was not significantly affected by time of insemination but tended to be higher for heifers bred 26 and 30 hr after first being detected in standing estrus (78.9% and 70.0% vs. average 59.2%). Treatment with a 7-day norgestomet implant plus a single injection of PGF(2alpha) 24 hr before or at implant removal appears to be a practical technique for synchronizing estrus in cycling heifers without affecting conception.

Journal Article↗

PubMed1969

[Pain].

Explore the source record for details and available documents.

Pain↗

PubMedDate not supplied

Fluctuation of skin lymphatic capillary pressure in controls and in patients with primary lymphedema.

The microlymphatic pressure was monitored by using the servo-nulling technique at the forefoot skin in 24 healthy volunteers (number of capillaries studied: 97) and in 27 patients with primary lymphedema (capillary number: 67). The lymphatic capillaries were stained by fluorescence microlymphography with fluorescein isothiocyanate-dextran 150 and cannulated using glass needles with a diameter between 7 and 9 microns. The lymphatic capillary hypertension described recently in primary lymphedema was confirmed in this series (mean pressure of controls 6.7 +/- 3.8 and, of patients 12.8 +/- 5.9 mm Hg; p < 0.001). Two patterns of pressure fluctuation were observed: rhythmic low-amplitude (mean value 3.7 mm Hg) waves with a frequency identical to respiration (respiratory movements of the thorax recorded simultaneously by a photo cell) and spontaneous nonrhythmic, low-frequency waves with a higher amplitude (mean value 5.5 mm Hg). The prevalence of waves synchronous with respiration was identical in patients and controls, whereas the low-frequency waves exhibited a significantly (p < 0.05) higher prevalence in the patients (41.7%) than in the controls (70.4%). The hypothesis is advanced that in primary lymphedema a considerable amount of lymphatic fluid is removed by lymphatic pathways with small calibre and high resistance, resulting in microvascular hypertension, and that contractions of the few preserved large proximal lymphatic collectors are enhanced. The latter mechanism could explain the increased prevalence of spontaneous microlymphatic pressure fluctuations with high amplitude and low frequency.

Adolescent↗

PubMedDate not supplied

Effects of subcutaneous insulin-like growth factor-I infusion on skin microcirculation.

When healthy volunteers were treated with human insulin-like growth factor-I (IGF-I), mild generalized edema often developed. In the present study, the effect of IGF-I on cutaneous capillary permeability and microvascular skin blood flow was investigated using fluorescence videomicroscopy and laser Doppler fluxmetry. Transcapillary diffusion of intravenously injected sodium fluorescein (NaF) was quantitated by videodensitometry in terms of fluorescent light intensities (FLIs) 5, 10, 20, 30, 60, 120, 180 and 300 s after the first appearance of the dye. Laser Doppler fluxmetry was performed at rest (LDFrest) and during postocclusive reactive hyperemia (LDFpeak). Eight healthy subjects (3 women, 5 men; mean age 28 years, range 24-30 years) were investigated. The sensing site was the skin on the right dorsal wrist. Measurements were performed after 4 days of subcutaneous infusion of 0.9% saline (control) and of IGF-I. Mean values for the FLI were significantly higher after IGF-I than after saline infusion (p < 0.05), when the FLIs were expressed in arbitrary units. As percentages of their individual maxima, the differences were significant (p = 0.05) after 60 s (23.6 +/- 6.6% with NaCl and 31.9 +/- 7.6% with IGF-I). LDFrest and LDFpeak tended to be higher after IGF-I treatment without achieving statistical significance (p = 0.176). The mean appearance time of the dye after injection was significantly shorter (p = 0.016) in the IGF-I group than in the control group (32.0 +/- 8.4 s with IGF-I, 42.4 +/- 8.3 s with NaCl).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMedDate not supplied

Simultaneous assessment of muscle and skin blood fluxes with the laser-Doppler technique.

The laser-Doppler technique was used to assess local muscle and skin blood fluxes at the lower limb in 20 healthy volunteers. After puncturing the anterior tibial muscle with a steel cannula, a single-fibre probe with a diameter of 0.5 mm was inserted into the muscle. Simultaneously, the skin blood flux was measured at calf and foot. The muscle blood flux at rest was 3.5 to 4 times higher than the skin blood flux at calf or foot. The spatial variability of the muscle blood flux at three different sites of measurement was considerable and tended to be higher than in the skin of the calf. After an arterial occlusion lasting 3 min, peak flux was reached in the muscle after 18.7 +/- 9.8 s, in the skin of the calf after 16.8 +/- 9.3 s, and in the skin of the foot after 22.9 +/- 14.6 s (NS). The relative flux increase during reactive hyperaemia was significantly lower in the muscle (2.7 +/- 1.3) than in the skin of the calf (3.9 +/- 1.9; p<0.05) or the foot (5.1 +/- 3.5; p<0.005). The reproducibility of reactive hyperaemia response in muscle was excellent with unchanged probe position, but exhibited a marked variability on different days. The laser-Doppler technique provides the possibility for simultaneous measurement of flow dynamics in muscle and skin with a high temporal resolution. Methodological problems include differences in probe geometry of the single-fibre compared to standard probes and differences in optical properties of the tissues. Direct comparison of flux values may, therefore, be subject to criticism, but not the comparative analysis of relative flux changes. The influence of tissue trauma on muscle blood flux has to be considered for the analysis of flux data.

Adult↗

PubMedDate not supplied

A glimpse of community-based rehabilitation in China.

As in other developing countries, community-based rehabilitation (CBR) in China is very important. However, because of differences in the social system, economy, and cultural level, it is impossible to implement a uniform model of CBR. This paper introduces material to show how CBR in China tends to be spontaneous. Experience of CBR stations in Shenyang has initiated a new approach to CBR within the cultural characteristics of China.

Activities of Daily Living↗

PubMedDate not supplied

Detection and analysis of human papillomavirus 16 and 18 homologous DNA sequences in oral lesions.

The prevalence of human papillomavirus (HPV) 16 and 18 was investigated in oral lesions of the population of northeast China including squamous cell carcinomas (SCCs), candida leukoplakias, lichen planuses and papillomas, by southern blot hybridization with polymerase chain reaction (PCR). Amplified HPV16 and 18 E6 DNA was analyzed by cycle sequence. HPV DNA was detected in 14 of 45 SCCs (31.1%). HPV18 E6 DNA and HPV16 E6. DNA were detected in 24.4% and 20.0% of SCCs. respectively. Dual infection of both HPV 16 and HPV 18 was detected in 6 of 45 SCCs (13.3%), but not in other oral lesions. HPV 18 E6 DNA was also detected in 2 of 3 oral candida leukoplakias, but in none of the 5 papillomas. Our study indicated that HPV 18 infection might be more frequent than HPV 16 infection in oral SCCs in northeast Chinese, dual infection of high risk HPV types was restricted in oral SCCs, and that HPV infection might be involved in the pathogenesis of oral candida leukoplakia.

Candidiasis, Oral↗