Ovarian haemangiomas and stromal luteinization.
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Aged↗
Biomedical subjects
S Wells
Publications and source records attributed to S Wells.
Systemic argyria.
A 74 year old man presented with signs and symptoms of mild cardiac failure. His face and chest were severely discoloured, which was thought to be due to cyanosis. He deteriorated and died of bronchopneumonia. At post mortem examination multiple organs, including the skin, showed silver pigment deposition; he also had a gastric malignant neuroendocrine tumour. He gave no history of contact with silver compounds. Systemic argyria caused by chronic ingestion of silver compounds is a rare condition which, apart from its cosmetic effects, is thought to be relatively harmless; it is not thought to be carcinogenic. This condition can pose diagnostic problems for both clinicians and pathologists.
Adenoma↗
Unusual case of large bowel obstruction.
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Aged↗
Lionfish envenomation of the hand.
Lionfish (Pterois volitans) envenomation of the hand causes excruciating pain and occurs in three grades: (1) erythematous reaction, (2) blister formation, and (3) dermal necrosis. The initial treatment in all cases is to soak the hand in nonscalding water (45 degrees C) until the pain subsides by denaturing the thermolabile venom proteins. The blisters should be immediately excised to prevent dermal necrosis, inasmuch as the blister fluid contains residual active venom. To prevent a hypersensitivity reaction, any further contact with the fish should be avoided.
Adult↗
Postoperative recovery: how diabetes complicates care.
Diabetic patients comprise a significant portion of the overall number of coronary artery bypass graft surgery patients. These patients are at greater risk to develop complications postoperatively because of associated changes in their cardiovascular system. Diabetic patients may respond differently to cardiac surgery if they have autonomic neuropathy, microvascular changes, and macrovascular disease. Nurses must be aware of the effect of diabetes on the cardiovascular system and how this can affect patient recovery.
Cardiac Output↗
Chondroid syringoma with hyaline cell change.
Four cases of chondroid syringoma containing large numbers of hyaline or plasmacytoid cells are described. Three cases occurred in the hand and one in the foot. Hyaline cells are commonly seen in mixed tumours and myoepitheliomas of salivary glands and rarely in chondroid syringomas. The hyaline-cell change in three of the cases initially caused diagnostic difficulties and the possibility of sarcoma was raised in two cases. In addition to the characteristic hyaline cells, the presence of tubulo-glandulo-ductal structures, benign squamous epithelium and myxochondroid stroma aided diagnosis. Immunohistochemically, the hyaline cells exhibited positivity for vimentin, cytokeratin, S-100 protein, carcino-embryonic antigen, focal glial fibrillary acidic protein (3 cases), neuron-specific enolase (3 cases) and focal alpha-smooth muscle actin (2 cases). Occasional cells were Ber EP4 positive (2 cases). In some cells, a striking peripheral ring-like positivity for cytokeratin and S-100 protein was noted. Ultrastructurally, desmosomes, varying numbers of tonofibrils and non-bundling intermediate filaments were seen. Scanty fine filaments with vague focal densities were detected in some cells. Our studies suggest that the hyaline cells represent modified epithelial as well as myoepithelial cells. One of our cases also exhibited collagenous spherulosis.
Actins↗
Entry level midwifery skills list revision #3.
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Certification↗
Direct entry midwifery education: caught in the middle of the maternity care crisis and a political-educational debate.
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Certification↗
Humidification for ventilated patients.
When a patient is intubated with an endotracheal tube for artificial ventilation the humidifying, warming and filtering functions of the nose and upper airways are bypassed. This article reviews the need for the provision of artificial humidification, optimal levels that should be provided and the two types of device which are available to achieve this, namely, the heat and moisture exchanging devices and the heated vaporising or nebulising humidifiers. Finally a study is presented which documents the exact level of moisture delivered to patients by the cascade water bath humidifier.
Equipment Design↗
Modifying a hospital-wide PCS for burn wound care.
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Burn Units↗
Pseudoangiosarcomatous carcinoma: a clinicopathological study of seven cases.
Seven cases of carcinoma mimicking angiosarcoma occurring in skin (3 cases), breast (3) and lung (1) are described. The cutaneous, pulmonary and one of the breast carcinomas were poorly differentiated and squamous in type; the other two breast tumours were poorly differentiated ductal carcinomas with focal squamous differentiation. Histologically, the pseudoangiosarcomatous pattern was due to complex anastomosing channels and spaces lined by neoplastic cells. The spaces contained hyaluronic acid. The neoplastic cells exhibited cytokeratin positivity but yielded negative results with the endothelial cell markers, factor VIII-related antigen and CD 34 (QB-END/10). Two breast tumours showed binding of UEA-1. Ultrastructurally, unequivocal epithelial differentiation was demonstrated in six of the cases. Pathogenetically, these tumours appeared to be variants of acantholytic squamous cell carcinoma. Recognition of this unusual form of carcinoma is important, as an incorrect diagnosis of angiosarcoma may lead to inappropriate treatment and prognostication.
Aged↗
A case of mosaicism involving an unstable 13/14 Robertsonian translocation.
Prenatal diagnosis of mosaicism involving an apparently unstable 13/14 Robertsonian translocation is reported. This illustrates the difficulties encountered in counselling when mosaicism is ascertained prenatally. Other reported examples of apparently unstable Robertsonian translocations are discussed.
Adult↗
Molecular and cytogenetic analysis of a familial microdeletion of Xq.
Cytogenetic analysis of a male infant referred for poor neurological development and failure to thrive showed a microdeletion of the X chromosome, his karyotype being 46,Y,del(X)(pter----q21.1:: q21.2----qter). His mother and grandmother were also found to carry the deletion. DNA probes were used to define the deletion molecularly and it was shown to span intervals 2 to 6 of Cremers et al, a portion of Xq that contains the TCD gene and genes whose absence is associated with deafness and mental retardation. RFLP analysis together with X inactivation studies using the probe M27 beta verified the carrier status of the female relatives and showed non-random X inactivation in the heterozygous females.
Chromosome Banding↗
Practice patterns of obstetricians and gynecologists in Jacksonville, Florida.
Ninety members of the Jacksonville Obstetrical and Gynecological Society were surveyed as to their practice patterns; 55 responded. Due to fear of litigation, 34% had stopped delivering obstetrical care and 63% plan to discontinue perinatal care during the next ten year. At least one malpractice claim had been filed against 51%; 9% had two, and 11% three or more. Prenatal and intrapartum testing has increased primarily because of fear of litigation. Obstetric fees increased 44% during the last five years, according to the survey, compared to a Consumer Price Index rise of 20%. Mean malpractice premiums rose 42% during the same interval.
Adult↗
Eosinophilic meningoencephalitis due to Angiostrongylus cantonensis as the cause of death in captive non-human primates.
Fatal eosinophilic meningoencephalitis due to Angiostrongylus cantonensis is reported in captive non-human primates. A howler monkey (Alouatta caraya) at the Audubon Park and Zoological Gardens, New Orleans, LA, died 21 days after initial clinical symptoms. A white-handed gibbon (Hylobates lar) died at the Ardastra Gardens and Zoo, Nassau, Bahamas, 17 days after onset of symptoms. Both had access to free-ranging gastropods within the zoos. These are the first reported cases of natural infection by A. cantonensis in non-human primates in the western hemisphere.
Alouatta↗
Language laterality in Navajo reservation children: dichotic test results depend on the language context of the testing.
Language lateralization in 40 Navajo and 20 Anglo fifth graders was assessed via the Dichotic Consonant-Vowel Task (DCVT). One group of Navajo children was tested by an experimenter who spoke only Navajo with them. The other Navajo group and the Anglo group were tested by an experimenter who spoke only English to them. Strong right ear advantages (REAs) were obtained for the Anglo group and for the Navajo group tested by the Navajo-speaking experimenter. The Navajo group tested by the English-speaking experimenter showed minimal, nonsignificant REAs. Previous findings of an absence of REAs in Native American children failed to consider the possibility that this might occur only when the experimenter does not speak the dominant language of the children. Our results are not consistent with the view that Native Americans are more right hemisphere dominant as a function of an "appositional" mode of language and thought.
Arizona↗
Localization of the genetic defect in multiple endocrine neoplasia type 1 within a small region of chromosome 11.
Multiple endocrine neoplasia type I (MEN-1), a Mendelian disorder with an autosomal dominant mode of inheritance, causes hyperplasia in the parathyroid glands and hyperplasia or neoplasm in the anterior pituitary gland and/or the pancreatic islets. The genetic defect responsible for MEN-1 in three families was recently mapped to the long arm of chromosome II by linkage between the MEN-1 locus and the gene for skeletal muscle glycogen phosphorylase (PYGM) at 11q13. We have constructed a genetic linkage map of seven markers in the vicinity of the MEN-1 locus that has allowed us to map more precisely the gene associated with MEN-1; the target region has been narrowed to about 12 cM. The closely linked markers will be useful also for identification of likely carriers in families in which an allele responsible for MEN-1 segregates.
Chromosome Mapping↗
Helically organized macroaggregates of pigment-protein complexes in chloroplasts: evidence from circular intensity differential scattering.
Angle dependence of circular intensity differential scattering (CIDS) and of nonpolarized scattering was determined in isolated spinach chloroplasts at 514.5 nm. CIDS between 0 degrees and 170 degrees was independent of the nonpolarized scattering and showed intense lobes of alternating signs, exhibiting the negative and positive maxima around 15 degrees and 70 degrees, respectively. These results provide experimental evidence for the existence of large helically organized macroaggregates of pigment-protein complexes in thylakoid membranes. Modeling of the CIDS data by a simple helical array of uniaxial polarizable groups suggests that the chiral structure is left-handed with pitch and radius of the order of 385 nm.
Chloroplasts↗