Search PubMed⌕ Search

Biomedical subjects

S Weller

Publications and source records attributed to S Weller.

234 records · Page 13Linked to original sources
PubMedDate not supplied

[Staphylococcus epidermidis causing infections in trauma surgery].

During 27 months at the Tübingen Accident Hospital, Staphylococcus epidermidis could be found in 464 of 1824 bacteriological wound swabs. This normally had to be considered as contamination. However, in at least 69 cases, S. epidermidis alone undoubtedly caused or maintained a fresh or chronic infection of the bone and soft tissue following aseptic orthopedic surgery, whereby the infection was temporarily sustained by S. epidermidis during pathogen change. The findings are demonstrated and compared with the literature.

Fracture Fixation↗
PubMedDate not supplied

Retrospective analyses of additional services for methadone maintenance patients.

We report on the 6-month outcome of a retrospective analysis of additional treatment services for patients entering a methadone maintenance program who transferred from community methadone treatment programs (n = 83) or entered off the street (n = 83) not currently on methadone. Patients were participating in a clinical treatment trial examining the effectiveness of Community Reinforcement Approach and Relapse Prevention. Patients in the methadone transfer group were using less heroin at intake than patients newly initiated onto methadone and both groups improved from additional treatment services in the following problem areas specifically: drug, alcohol, legal, employment, social, and in some measures of psychiatric distress. Therefore, both groups of patients in this study benefited from additional treatment services.

Adult↗
PubMedDate not supplied

[Extra-ligamentous valgisation additive tibial head osteotomy. Indications-technic-complications-errors. Critical analysis].

In patients with posttraumatic or idiopathic gonarthritis, varus deformity and stable medial collateral ligaments the valgus high tibia correction osteotomy in the open wedge method is performed extraligamentary. An autologous wedge from the iliac crest is used, a bridging plate osteosynthesis brings stability for early movement. 58 patients with 64 osteotomies operated between 1981 and 1986 underwent a follow-up examination. There was an infection rate on the tibial head of 15%. The reason for that was not in the procedure itself but in its application and performance. Respecting the site of osteotomy (less than or equal to 6.5 cm below tibial joint line), the size of the wedge at its basis (less than or equal to 10 mm), a strong indication in cases of repeated interventions and the correct technical performance of the procedure we see in the high tibia valgus osteotomy (open wedge method) a proper way of treatment in unilateral varus gonarthritis or varus deformities compared to other existing methods.

Bone Plates↗
PubMedDate not supplied

[Treatment of necrosis of the femur condyle with a medial gliding knee prosthesis].

Spontaneous osteonecrosis of the femoral condyles occurs rather seldom particularly in elderly patients. Whereas some authors recommend valgusosteotomy and bone drilling, implantation of a unilateral knee prosthesis should be performed in the presence of large defects. It is reported a series of 11 patients suffering from osteonecrosis of the femoral condyle. All patients were treated by a unilateral knee prosthesis with good results except one case. The filling of the defect with cancellous bone prior to the implantation of the condylar part of the prosthesis is mandatory.

Aged↗
PubMedDate not supplied

Disposition of acrivastine in the male beagle dog.

Three male beagle dogs were given 10 mg/kg iv and oral doses of [14C]acrivastine, a novel nonsedating antihistaminic agent, in a nonrandomized crossover experiment. Urine and feces were collected for 72 hr after dosing. After iv dosing, a mean of 34% was recovered in the urine, and 63% was recovered in the feces. After po dosing, a mean of 29% of the radiocarbon was recovered in the urine, and 63% was recovered in the feces (dose adjusted for 14% lost in vomitus). Acrivastine and three major metabolites were detected in the excreta. The metabolites were identified as a side-chain-reduced analog of acrivastine (metabolite 3, 270C81), a gamma-aminobutyric acid analog of 270C81 (metabolite 2), and a benzoic acid analog of 270C81 (metabolite 1). After iv dosing, 34% of the dose was excreted as parent drug, 21% as metabolite 3, 15% as metabolite 2, and 6% as metabolite 1, while after po dosing, 35% of the dose was excreted as parent drug, 18% as metabolite 3, 11% as metabolite 2, and 7% as metabolite 1. Pharmacokinetic analysis of acrivastine plasma concentration-time curves after both routes of administration indicated a mean total body clearance of 17.3 ml/min/kg, a Vss of 0.93 liter/kg, a terminal half-life of 0.7 hr, and an oral bioavailability of 40%. The apparent plasma half-life of the metabolite, 270C81, was 1.5 hr. Analysis of AUC values indicated that greater amounts of 270C81 than acrivastine circulated in plasma after both iv and po dosing, and that first-pass metabolism of acrivastine to 270C81 occurred. The results indicated that acrivastine was extensively metabolized in the dog to 270C81 and suggested that 270C81 itself underwent further metabolism to metabolites 1 and 2.

Animals↗
PubMedDate not supplied

Medullary nailing according to Swiss study group principles.

Internal fixation of long tubular bone fractures by intramedullary nailing has become established worldwide as an efficient and successful procedure, besides the methods of interfragmentary compression, buttress and adaptation, intramedullary splinting and stabilization constitute the basic principles of osteosynthesis. Improvements in knowledge of equipment, indications, technique, aftercare and possible complications have increased the success of intramedullary nailing. The results of 1,905 intramedullary nailings of femur and tibia demonstrate that with other methods of osteosynthesis poor results usually are attributable to an inappropriate indication and/or a faulty surgical technique. Occasionally a failure may stem from the surgeon's technical incompetence or inexperience.

Absenteeism↗