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Biomedical subjects

S Weiner

Publications and source records attributed to S Weiner.

At least 253 records · Page 14Linked to original sources
PubMedDate not supplied

Ultrasound in the evaluation and management of the isoimmunized pregnancy.

Real-time ultrasound was a valuable adjunct in the management of 57 consecutive isoimmunized pregnancies. The pathophysiology of hydrops fetalis as it affects the sonographic anatomy of the fetus and placenta is discussed. Real-time ultrasound was slightly more accurate than amniotic fluid bilirubin analysis in predicting moderate to severe erythroblastosis fetalis. The most useful finding was a disproportionate growth of the fetal abdominal circumference in relationship to the biparietal diameter. Ultrasound proved invaluable in several difficult situations, such as contaminated amniotic fluid, ruptured membranes, and twins. Suggestions for the further quantitation of this diagnostic test are explored.

Adult↗
PubMedDate not supplied

A consultation-liaison psychiatry clinical clerkship.

Toward the goal of increasing the relevance of clinical psychiatry to the future practice of medicine, a full-time psychiatry clerkship has been developed on the Consultation-Liaison Psychiatry Service at the University of Vermont. This new Psychiatry Clinical clerkship was begun on a pilot basis in January, 1973, and made fully operational in January, 1974. It uses the problem oriented medical record system and the audit of student performance as basic instructional tools. A description of the background or curricular matrix of the Consultation-Liaison Psychiatry Clinical Clerkship (CLPCC) is followed by an outline of the rotation's goals, and evaluation and educational strategies as developed over 2 years. Certain performance outcomes are reported for the 1 year of full operation. These outcomes are parameters of student performance on several standardized measures applied to all Psychiatry Clerkship students. The CLPCC students seem to be at least as adequate as students on all other clerkship rotations, in terms of their knowledge of psychopharmacology, their use of the Problem Oriented Record, their ability to assess psychosocial problems, and their ability to define a psychosocial treatment plan. Further, the CLPCC students are statistically significantly more positive about their rotation as an educational experience compared with students on other psychiatry rotations. While further evaluation measures are planned to compare the CLPCC students with those who have had one of the several traditional clinical clerkship experiences in psychiatry, our experience to date would indicate that the CLPCC is a viable alternative to traditional clerkships on psychiatric services and one that may enable a greater application of psychiatric principles to the practice of medicine.

Achievement↗
PubMedDate not supplied

Current perspectives on pacing therapy in cardiomyopathies.

Hypertrophic cardiomyopathy (HCM) is a complex disease that is sometimes difficult to control with medical therapy. Surgical treatment is highly effective but can be associated with significant morbidity and mortality. It has been suggested in uncontrolled studies that patients with obstructive HCM may improve symptomatically when treated with dual-chamber pacing. Several hypotheses have been suggested to explain this phenomenon, but the mechanism still remains unclear. Many recent randomized trials showed much less uniform effects on symptoms than previously reported. These results indicate the need for further comprehensive inquiry into the effects of pacing on HCM before it can be recommended for widespread use. The data on the benefit of pacing therapy in dilated cardiomyopathy are much more recent and limited. Initial optimistic reports have been only partially confirmed.

Cardiomyopathy, Dilated↗
PubMedDate not supplied

Gravidas' responses to realtime ultrasound fetal image.

One hundred women in various stages of pregnancy were questioned before and after viewing their fetuses through realtime ultrasonographic scanning. For the majority of these women, perceptions of the fetus changed following this visualization. Viewing gave some a greater sense of attachment to the fetus, but for a few, this attachment also gave a greater sense of vulnerability with regard to the outcome of the pregnancy.

Evaluation Studies as Topic↗
PubMedDate not supplied

Percutaneous umbilical blood sampling.

Percutaneous umbilical blood sampling (PUBS) provides a new and exciting method for assessment and management of certain fetal disorders. This procedure offers direct access to the fetal circulation for obtaining blood samples or for transfusing the fetus in utero. Although investigational, PUBS offers treatment approaches that were not previously available. This ability to treat the fetus in utero can prolong pregnancy, resulting in decreased prematurity and mortality rates for infants with erythroblastosis fetalis. This article describes the PUBS procedure and the indications for PUBS and discusses the nursing implications associated with the care of women undergoing PUBS.

Blood Specimen Collection↗
PubMedDate not supplied

Care of the neonate with erythroblastosis fetalis.

Erythroblastosis fetalis, hemolytic disease of the newborn, occurs when an isoimmunized mother produces antibodies that cross the placenta and cause hemolysis of fetal red blood cells. This hemolysis can be accompanied by severe anemia, ascites, pleural and pericardial effusions, congestive heart failure, and neurological damage with resultant perinatal mortality. Rh isoimmunization in pregnancy still occurs in spite of the advent of Rh immune globulin. This article describes the complex management and nursing implications associated with caring for the neonate with erythroblastosis fetalis.

Anemia, Hemolytic↗
PubMedDate not supplied

Third generation dentin bonding agents: a microleakage study.

This article examines and compares the extent of microleakage after 24 hours in freshly extracted teeth using three newer or "third generation" dentin bonding agents. Gluma/Pekalux and Scotchbond 2/Silux were more effective in preventing microleakage in cementum/dentin margins than was Universal Bond/Prisma Micro-fine.

Adhesives↗
PubMedDate not supplied

Hepatic mesenchymal hamartoma associated with mesenchymal stem villous hyperplasia of the placenta.

A rare case of prenatally diagnosed hepatic mesenchymal hamartoma associated with mesenchymal stem villous hyperplasia of the placenta is presented and the literature reviewed. The placenta was noticed to have multiple cysts at 16 weeks' gestation and elevated maternal serum alpha-fetoprotein was present. Cystic liver masses were first detected in the fetus at 34 weeks' gestation. The liver mass showed a progressive enlargement during the third trimester and after birth, necessitating extended left hepatic trisegmentectomy at 3 months of age. Histological examination established the diagnosis of mesenchymal hamartoma of the liver and mesenchymal stem villous hyperplasia of the placenta. This is the first report of this association in which both lesions were diagnosed in utero and confirmed by histology after delivery. The likely pathogenesis of these strikingly similar lesions is discussed.

Adult↗
PubMedDate not supplied

Overview of studies comparing human normal cartilage with minimal and advanced osteoarthritic cartilage.

A major area under study in the osteoarthritis (OA) research field is the characterization of specific molecular and biochemical changes that distinguish advanced diseased cartilage from less involved or normal tissue. This information is important to better define the pathogenic mechanisms that are operating during OA progression and to identify disease-specific markers. This review describes recent studies that have addressed changes in chondrocyte gene expression, proliferation, and apoptosis in "experimental" (more advanced OA cartilage) versus "control" (less involved or non-OA cartilage). Included is a comprehensive listing of recently published studies in this area with general findings. The review also includes a discussion of study design and the strengths and weaknesses of the various approaches. In addition, specific strategies to deal with some of the important issues are discussed. One particular model utilizing minimal and advanced OA cartilage obtained from the same patient is described in more detail.

Apoptosis↗