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Biomedical subjects

S Webb

Publications and source records attributed to S Webb.

At least 307 records · Page 17Linked to original sources
PubMed1979

The dose in water surrounding point isotropic gamma-ray emitters.

A Monte Carlo method has been used to calculate the dose distribution around point gamma-ray emitters in water. Five gamma-ray emitting radionuclide, 60Co, 137Cs, 192Ir, 198Au and 226Ra, which are commonly used in radiotherapy interstitial implants have been considered. The results are in substantial agreement with those derived using a combination of experimental and theoretical data.

Gamma Rays↗
PubMed1979

The absorbed dose in the vicinity of an interface between two media irradiated by a 60Co source.

Monte Carlo techniques are used to generate the distribution of absorbed dose in the vicinity of an interface between two media. Computer-generated distributions for absorbers comprising the media carbon-copper, water-aluminium and aluminium-water are presented. The features of the distributions in regions of electron equilibrium and non-equilibrium, in particular finite discontinuities at the boundaries and subsequent build up or build down, are discussed both qualitatively and quantitatively. The difficulties inherent in interpreting ionization measurements in the neighbourhood of interfaces are outlined.

Aluminum↗
PubMed1978

Immunotherapy of an established rat mammary adenocarcinoma (13762A) with intratumor injection of Corynebacterium parvum.

We studied the effects of intratumor injection of Corynebacterium parvum vaccine on the survival of 13762A tumor-bearing rats. Vaccine injection of established (7-day-old) tumors produced dose-related prolongation of survival and cured some animals. Although 30 to 40% of the vaccine-injected primary tumors regressed, recurrences and continued growth of metastases ultimately killed one-fourth of the regressors. Rats given 1500 microgram of C. parvum intratumorally at 7 days, with or without later primary tumor excision at 20 days were cured at a rate of 10 to 40%. Repeated injections improved the results (60%). C. parvum injections delayed until 12 and 17 days were ineffective. Cured rats were immune to rechallenge with 13762A tumor.

Adenocarcinoma↗
PubMed1978

Destruction of regional lymph node metastases of rat mammary adenocarcinoma 13762A by treatment with Corynebacterium parvum.

Intratumoral administration of Corynebacterium parvum to 13762A tumor-bearing rats on Day 7 of tumor growth, followed by primary tumor excision on Day 20, regularly cured about 40% of the animals and significantly prolonged survival in the remainder. Rats treated by surgery alone on either Day 7 or Day 20 died with metastases to axillary lymph nodes and lungs. Tumor was established in axillary lymph nodes by Day 7. Therefore, intratumoral injection of C. parvum on Day 7 destroyed metastases already established at this site. Growth of tumor in axillary nodes of rats treated but not cured by C. parvum was significantly slower than growth in untreated rats.

Adenocarcinoma↗
PubMed1970

Comparison between local injections of silicone oil and hydrocortisone acetate in chronic arthritis.

One of three preparations-silicone oil, hydrocortisone acetate, and hydrocortisone acetate plus saline-was injected into 22 osteoarthritic and 49 rheumatoid knees. Silicone injected into stiff, dry, grating knees which were the site of chronic arthritis did not promote better movement than did hydrocortisone alone. Hydrocortisone plus saline, however, appeared to be more effective than silicone or hydrocortisone alone in increasing movement in rheumatoid knees. The maximum increase in movement was found to occur three weeks after each of the three different injection preparations.

Adult↗