Biomedical subjects
S Watson
Publications and source records attributed to S Watson.
Trust saves money by taking students' homes.
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Who's to blame?
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Nurses not invited.
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Dramatic developments in nursing.
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The public says pay up.
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Lessons to be learned.
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Meeting the needs of young carers.
Up to 40,000 young people in the UK may be caring for a sick or elderly relative but they may not be getting the support they deserve for themselves. This article suggests that health professionals and teachers do not always recognise the problems that young carers face, so cannot support them. The author recommends further training for these professionals to increase their awareness of young carers' needs.
Network support critical in choosing a lab system.
When providers acquire laboratory information systems, they're looking beyond improving their lab operations to determine how the software will provide data to build computerized patient records throughout an integrated delivery system. Vendors are beginning to differentiate themselves based on how effectively their systems support the formation of enterprisewide information networks.
Using massage in the care of children.
Touch has long been an under-valued aspect of care, but more nurses are now bringing its benefits to patients in the form of massage. Sue Watson reviews the literature and discusses how massage can help in the care of infants and children.
Pyrogenicity of E. coli 055:b5 endotoxin by the USP rabbit test--a HIMA collaborative study.
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A phase I-phase II study of vinorelbine with cisplatin, 5-fluorouracil, and leucovorin for advanced non-small cell lung cancer.
PURPOSE: The combination of cisplatin, 5-fluorouracil, and leucovorin (PFL) has been reported to have a 29% response rate in advanced non-small cell lung cancer. Vinorelbine, a semi-synthetic vinca alkaloid, has also been reported to have single-agent activity in this disease. We designed a phase I-II study in which escalating doses of vinorelbine were added to PFL to define the dose-limiting toxicity and maximum tolerated dose of vinorelbine, and to determine the response rate and survival at the recommended phase II dose. PATIENTS AND METHODS: This study enrolled patients between December 1991 and August 1993. Eligibility criteria included histologically or cytologically documented stage III or IV non-small cell lung cancer, measurable or evaluable disease, and no prior chemotherapy. Treatment consisted of escalating doses of vinorelbine (starting at 20 mg/m2) on days 1 and 6, cisplatin 100 mg/m2 on day 2, and 5-fluorouracil as a continuous infusion at 800 mg/m2/day for 4 days (days 2-5) with leucovorin 100 mg orally every 4 hours on days 1 through 5. Cycles were repeated every 21 days. RESULTS: Forty patients were treated during the study. The median age of the patients was 58 (range, 33-75) and 36 patients had a performance status of 0 or 1. Dose-limiting neutropenia was observed in both patients treated with vinorelbine at 25 mg/m2. At the recommended phase II vinorelbine dose of 20 mg/m2 on days 1 and 6, myelosuppression remained the most common toxicity, with 22 patients (55%) having grade 4 neutropenia. Fifteen patients (38%) required hospital admission for neutropenic fever; two died of neutropenic sepsis. Of 33 patients evaluated, 2 patients achieved a complete response and 10 patients achieved a partial response (overall response rate, 30%; 36% of the evaluated patients). Median survival was 10.4 months for the entire cohort (16.4 months for those with stage III disease and 9.6 months for patients with stage IV disease) and 1-year survival was 45%. The overall median time to progression was 8.1 months. CONCLUSIONS: The maximum tolerated dose of vinorelbine given on days 1 and 6 with PFL is 20 mg/m2; myelosuppression is the dose-limited factor. The response rate is similar to rates observed in prior studies of combination chemotherapy, but the median survival of patients with stage IV disease exceeds that of many other regimens.