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Biomedical subjects

S Wapnick

Publications and source records attributed to S Wapnick.

80 records · Page 5Linked to original sources
PubMedDate not supplied

Alcohol ingestion-induced changes in the human rectal mucosa: light and electron microscopic studies.

Histologic and ultrastructural examination of specimens of rectal mucosa from 11 patients who had recently consumed excessive quantities of alcohol revealed marked pathologic changes. Goblet cells were decreased and a dense mononuclear cell infiltrate was seen on light microscopic study. Electron microscopy revealed swollen, distorted mitochondria and dilated and vesicular endoplasmic reticulum. These abnormalities disappeared after two weeks' abstinence. It is suggested that disordered organelle structure and function might contribute to the diarrhea frequently observed following excessive alcohol intake.

Adult↗
PubMedDate not supplied

Purulent pericarditis occurring in a patient with cecal carcinoma: report of a case.

We report the unusual concatenation of cecal carcinoma complicated by bacteremia and purulent pericarditis. The organism responsible for the pericarditis was not definitely established. The pericarditis was successfully managed by surgical drainage and antibiotic therapy. Colonic surgery followed eradication of the pericarditis.

Adenocarcinoma↗
PubMedDate not supplied

A retrospective comparison of functional renal failure in cirrhosis treated by conventional therapy or the peritoneo-venous shunt (LeVeen).

Between 1973 to 1976, 12 ascitic cirrhotic patients with a mean plasma creatinine (pCr) of 4.4 +/- 3.0 mg/dl) were treated conservatively. During the same period 11 cirrhotics with ascites (pCr 4.3 +/- 2.8 mg/dl) were treated with LeVeen peritoneal jugular shunt. In the medically treated group mean survival was 2.4 +/- 2.7 weeks after detection of pCr elevation greater than 2.3 mg/dl. The 11 surgical patients with pCr elevation above 2.3 mg/dl survived a mean of 21.8 +/- 34.5 weeks after surgery. Four patients survived more than six months. The LeVeen shunt also resulted in significant weight loss, reduction in blood urea nitrogen (BUN), elevation of serum sodium, and increase of renal clearance of sodium. In appropriately selected patients it reverses the hepato-renal syndrome.

Ascitic Fluid↗
PubMedDate not supplied

Serotonin in the portal vein after acidification.

To test whether serotonin release from the argentaffin cells of the intestinal tract can elicit peptic ulcer, rats were given intraduodenal infusions of N/10 and N/20 hydrochloric acid. Serotonin measured in the portal venous blood of rats which had had an intraduodenal infusion of N/20 HCl for five minutes was significantly higher than in the portal (P less than 0.05) or systemic (P less than 0.01) blood of control animals. After longer intervals serotonin release tapered off and measurements obtained 30 minutes after an infusion of N/10 HCl did not differ significantly from those in the controls.

Animals↗