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Biomedical subjects

S Wallace

Publications and source records attributed to S Wallace.

At least 487 records · Page 27Linked to original sources

Urographic manifestations of metastatic melanoma.

Urinary tract involvement with metastatic malignant melanoma occurs much more commonly than generally thought. It is usually part of a disseminated process with a poor life expectancy. The renal parenchyma is the most common site affected, although this is infrequently detected roentgenographically. Urothelial involvement of the renal pelves, ureters, and bladder manifests as single or multiple filling defects at pyelography. This appearance of metastatic melanoma of the urinary tract has not been previously described in the roentgenologic literature. Recognition is important to prevent unnecessary intervention and to guide palliative treatment.

Adolescent↗

Problems in selection of topical anti-inflammatory corticosteroids.

Desonide, a non-fluorinated topical corticosteroid (16-alpha-hydroxyprednisolone acetonide), is compared with its fluorinated analogue, triamcinolone acetonide, as to vasoconstriction ability and epidermal penetration rate. Clinical effectiveness of desonide is further assessed by means of a double-blind paired comparison with an accepted potent fluorinated steroid, betamethasone 17-valerate. It is demonstrated that fluorination of the steroid molecule is not necessary to achieve potent topical anti-inflammatory effect. Vasoconstriction and epidermal penetration are not enhanced by fluorination in the drugs studied.

Abdomen↗