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Biomedical subjects

S Wallace

Publications and source records attributed to S Wallace.

At least 361 records · Page 20Linked to original sources
PubMed1982

The clinical significance of lympho-venous anastomoses in malignant disease.

Pedal lymphangiography has revealed lympho-venous anastomoses (LVA) in 62 patients with malignant disease. The LVAs were caused by obstruction of lymph flow and the obstruction was secondary to surgery in 23 patients, abnormal lymph nodes in 16 and a combination of surgery and abnormal nodes in 14. In 16 patients the LVA led to portal radicals giving opacification of the liver. Chest X-ray examination was normal in 41 patients. In 5 patients the initial chest examination was normal, but lung metastases or widening of the mediastinum developed 1-5 years later. Twelve patients had lung metastases or widening of the mediastinum at the time of the diagnosis of LVA. Clinical follow-up was available in 47 patients, of whom 30 died 1-60 months after diagnosis of LVA. It is concluded that the prognosis of a patient with LVA is poor, provided the cause is not a negative lymph dissection or an unrelated surgical procedure. In patients with pathological lymph nodes the presence of LVA indicate an advanced involvement. Relatively few patients with LVA had or developed lung metastases indicating that the biology of the tumor and the patient is more important than LVA to develop lung metastases.

Adult↗
PubMed1982

A phase I study of intracarotid artery infusion of cis-Diamminedichloroplatinum(II) in patients with recurrent malignant intracerebral tumors.

A phase I study of intracarotid cis-diamminedichloroplatinum was performed in 11 patients with intracerebral tumors (five glioblastoma, four melanoma, one meningeal sarcoma, and one lung carcinoma) progressing after radiation +/- chemotherapy. The internal carotid artery was temporarily cannulated by a percutaneous transfemoral approach. All patients received i.v. heparin, mannitol, and fluids; seven received dexamethasone, 50 mg i.v., twice the day before and the day of treatment. Intracarotid cis-diamminedichloroplatinum, 60 to 100 mg/sq m in 175 to 250 ml 0.45% NaCl solution with 1000 units heparin, was infused over 1 hr. Six patients received two or more courses (maximum of 6) at 2- to 8-week intervals. Gastrointestinal toxicity was mild to moderate. Ototoxicity was minor. Central nervous system (CNS) toxicity was focal, severe, permanent, and possibly due to embolus in one patient at 75 mg/sq m; focal and reversible in one patient at 100 mg/sq m; and generalized but reversible in one patient at 75 mg/sq m. Possible CNS toxicity was noted in two additional patients. Two patients with CNS toxicity developed permanent ipsilateral retinal toxicity, and one patients without CNS toxicity developed bilateral decreased visual and auditory acuity 2 weeks after his sixth treatment. Renal and hematological toxicity and orbital pain were mild. Response status included: early death, one; probable responses, six (2+ 4+, 6, 6+, 8, and 8+ months); stabilization, two (3+ and 4 months); and failure, two. We recommend cis-diamminedichloroplatinum (60 mg/sq m) every 2 to 4 weeks for Phase II studies. Severe CNS and retinal toxicity are possible.

Adult↗
PubMed1981

Intraarterial cis-platinum for patients with inoperable skeletal tumors.

Twenty-three patients with inoperable skeletal tumors were treated with intraarterial cis-platinum prior to attempted surgery. The antitumor effect of intraarterial cis-platinum was monitored clinically by radiologic imaging techniques, and whenever possible, evaluated histopathologically by examinatin of surgical or biopsy tumor specimens. Objective responses were noted in 12 patients (52%) and included 2 complete, 7 partial and 3 less-than-partial remissions lasting from 14 to 70 weeks. Limb-saving surgery or hemipelvectomy became subsequently feasible in four and one patients respectively. Preoperative intraarterial cis-platinum is a safe procedure which might be used effectively in combination with other, more conventioal postoperative adjuvant chemotherapy against skeletal tumors.

Bone Neoplasms↗
PubMed1981

The palliative role of hepatic arterial infusion and arterial occlusion in colorectal carcinoma metastatic to the liver.

Fifty-five patients with metastatic colorectal carcinoma confined to the liver were treated with hepatic arterial infusion of floxuridine and mitomycin C. Tumour response rate was 43.4% and median overall survival was 11 months. Prolonged survival was associated with intentional or inadvertent occlusion of the hepatic artery. The median survival of twenty-four patients with arterial occlusion (15 months) was significantly higher than that of thirty-one patients without arterial occlusion (8 months).

Antineoplastic Agents↗
PubMed1981

Computed tomography in liposarcoma.

Seventeen cases with proven liposarcoma were evaluated by computed tomography (CT) to assess the specificity and value of this radiographic modality. A specific diagnosis of liposarcoma could be made in only four cases (22%). Despite its relative nonspecificity, CT proved extremely useful in the clinical evaluation of this tumor and evidenced considerable superiority to other radiographic methods. In several cases, CT was the only radiographic modality to demonstrate the presence of the lesion. The use of CT gained additional important information in approximately 50% of the cases studied.

Adult↗
PubMed1981

Sequence of regional chemotherapy and surgery. Management of colorectal adenocarcinoma confined to the liver.

Four patients with clinically nonresectable unilobar hepatic metastases from colorectal cancer were treated with a sequentially combined approach of intrahepatic arterial chemotherapy followed by surgery. Partial regression (greater than or equal to 50%) induced by chemotherapy and associated with a decline in plasma carcinoembryonic antigen level was followed successfully by a complete hepatic tumor resection in three out of four patients. All three patients continue to be free of disease from 13+ to 21+ months. This combined approach may improve the salvage rate of patients with regionally confined hepatic metastases.

Adenocarcinoma↗
PubMed1981

Technique and complications of renal carcinoma infarction.

The technique of renal arterial embolization in 150 patients with renal carcinoma using Gelfoam, Ivalon particles, and coils is described. The complications of the procedure and the morbidity and mortality following embolization are presented. The details of the postinfarction syndrome in the first 100 patients are analyzed. The prevention of these complications is discussed.

Embolization, Therapeutic↗
PubMed1981

Segmental renal artery embolization in solitary renal carcinoma.

Segmental renal artery embolization was performed as an alternative method to treat solitary renal carcinoma in 2 patients who were poor surgical candidates. In the first patient, a recurrent renal carcinoma in a solitary kidney was selectively embolized. Tumor aggression was observed eighteen months later. Recanalization of the segmental artery and collateral from the capsular artery required a second embolization. In the second patient with a transitional cell carcinoma involving the lower half of the only functioning kidney, segmental renal artery embolization successfully controlled his persistent gross hematuria.

Adenocarcinoma↗
PubMed1981

d-Amphetamine and phencyclidine alone and in combination: effects on fixed-ratio and interresponse-time-greater-than-t responding of rats.

The effects of three doses of d-amphetamine (0.5, 1.0, and 2.0 mg/kg) and phencyclidine (0.5, 1.0, and 2.0 mg/kg), alone and in combination, were assessed in rats performing under fixed-ratio 30 and interresponse-time-greater-than-15-sec food reinforcement schedules. When given alone, phencyclidine and d-amphetamine produced similar increases in responding under the interresponse-time-greater-than-t schedule, and decreases in responding under the fixed-ratio 30 schedule. Each drug decreased the number of reinforcers (food pellets) earned relative to control values under both schedules. The effects of the two drugs in combination were nearly always less than additive. That is, the effects of a given dose of phencyclidine and d-amphetamine together were less than an arithmetic summation of the effects of the drugs given alone.

Animals↗
PubMed1981

Embolization of renal carcinoma.

Preoperative transcatheter embolization of a renal neoplasm is helpful to the urologist, especially with large, hypervascular tumors. When combined with nephrectomy and hormonal therapy, it offers promise in the management of patients with renal carcinoma. Delay between embolization and nephrectomy seems to be important, but the optimal time for stimulating a therapeutic response has not been established. Among 49 patients in this series with known metastases, occlusion of the renal artery followed 4 to 7 days later by nephrectomy and hormonal therapy changed the course of the disease, producing a 36% response rate.

Adult↗
PubMed1981

Computed tomography of the infratemporal fossa.

Conventional radiography and polytomography supply much information about primary and secondary tumors involving the infratemporal fossa. However, computed tomography is the preferable method with which to make definitive evaluations.

Adult↗
PubMed1981

Protocol for delayed contrast enhancement in computed tomography of cerebral neoplasia.

One hundred cranial computed tomograms of adults with known or suspected intracranial neoplasm were analyzed retrospectively. Rapid high-dose intravenous contrast infusion (84.6 g l) was followed by immediate and 1 1/2-hour delayed scans. Delayed images afforded more information than the initial series in 67% of cases. 11.5% false-negative examinations (i.e., no tumor reported) would have resulted if studies were terminated after the immediate post-infusion scans. No patient experienced clinically detectable renal compromise.

Adult↗