Search PubMed⌕ Search

Biomedical subjects

S Wakisaka

Publications and source records attributed to S Wakisaka.

At least 163 records · Page 9Linked to original sources
PubMed1990

Intracranial and orbital metastasis of hepatocellular carcinoma: report of two cases.

Two cases of rare intracranial and orbital metastasis of hepatocellular carcinoma are presented. A 61-year-old woman was found to have a metastatic tumor in the right temporo-occipital lobe 1 year after undergoing treatment for a primary hepatoma. An osteolytic tumor was removed from the left orbit of a 58-year-old man and the primary tumor, a hepatoma, was discovered postoperatively. The intracranial and orbital tumors were verified to be hepatocellular carcinoma. Both patients died within 1 year of surgery. The relevant literature is briefly reviewed.

Brain Neoplasms↗
PubMed1990

Adenoid cystic carcinoma with intracranial extension: report of three cases.

Adenoid cystic carcinoma (cylindroma) usually arises from the salivary, lacrimal, or other exocrine glands, and is rarely encountered by neurosurgeons. The authors describe three cases involving intracranial extension. An intraorbital tumor in a 71-year-old man extended directly into the epidural space of the frontal base and destroyed the orbital roof. In a 53-year-old woman, the tumor arose from the area adjacent to the eustachian tube and invaded the Gasserian ganglion. In the third patient, a 58-year-old man, the tumor originated in the maxillary sinus and extended directly into the middle cranial fossa. In all these cases, the tumors were removed to the fullest extent possible. Although residual tumor was markedly reduced by radiation therapy, recurrence and metastases occurred within a few years. Thus, adenoid cystic carcinoma appears to be radiosensitive, but not curable by irradiation. In treating a recurrent tumor in one patient, we applied the so-called "two-route" chemotherapy (cisplatin and its antidote) in combination with radiation therapy. The tumor responded well to this therapy, although multiple pulmonary and bone metastases eventually led to the patient's death.

Aged↗
PubMed1990

Fine surface structure of an intraspinal neurenteric cyst: a scanning and transmission electron microscopy study.

The case of an 11-year-old boy with an intraspinal neurenteric cyst, which recurred 8 years and 3 months after surgery, is presented. Scanning and transmission electron microscopy of the cyst epithelium revealed marked resemblance to that of the respiratory tract, despite the presence of numerous goblet cells mimicking intestine on light microscopy study. Detailed ultrastructural findings are described.

Child↗
PubMed1990

Brain metastasis from transitional cell carcinoma of the bladder--case report.

A rare case of brain metastasis from a transitional cell carcinoma (TCC) of the bladder is presented. A 66-year-old female underwent total removal of a bladder carcinoma and postoperative radiation therapy and chemotherapy. Right hemiparesis and seizures developed about 16 months later, and a solitary brain metastasis was discovered in the left Rolandic area. The tumor was totally removed and microscopic examination showed it to be TCC.

Aged↗
PubMed1990

Microvascular decompression for trigeminal neuralgia with special reference to delayed recurrence.

Thirty-five patients with trigeminal neuralgia underwent microvascular decompression. Complete remission was obtained in 33 patients, while one was fair and another unchanged postoperatively. The clinical and operative findings were reviewed, analyzing the direction of vascular compression of the trigeminal nerve and the distribution of pain in the peripheral regions. There were some weak correlations between the direction of vascular compression and the distribution of pain. Neuralgia in the region of second branch of the trigeminal nerve (V2) or in the regions of V2 and third branch of the nerve (V3) was caused by compression from the ventral or ventro-rostral direction, in the region of first branch of the nerve from the ventro-caudal direction, and in the V3 region from the ventral, rostral, and dorsal directions of the nerve in general. In two patients who had had complete remission after first operation, trigeminal neuralgia recurred. They had typical intermittent painful attacks with a background of continuous dull pain or painful dysesthesia caused by Ivalon sponges inserted between the nerve and the offending vessel. Complete remission was again obtained after removal of these sponge pieces. We would like to stress continuous dull pain or painful dysesthesia in cases of delayed recurrence as indicators for re-exploration.

Adult↗
PubMed1990

[Moyamoya disease in fraternal twins].

The authors have reported here fraternal twins of moyamoya disease. The one has the onset at the age of two years and six months. Then he had suffered from multiple cerebral infarction and resulting in severe neurological deficits. Now he has right hemiparesis, left homonymous hemianopsia, aphasia and mental retardation. The encephalomyo synangiosis was done to the boy bilaterally at the age of five years. The other one has the onset at the age of five years and five months. He had good physical and neurological development. The Superficial temporal artery-Middle cerebral artery anastomosis and Encephalomyo synangiosis were done bilaterally. Now his development has no problems. The twins and their younger sister all have the same HLA type. The hereditary and environmental factors may be completely related to the pathogenesis of this disease.

Adult↗
PubMed1990

Acute phenytoin intoxication associated with the antineoplastic agent UFT.

Antineoplastic drugs are known to affect the intestinal wall and suppress the absorption of phenytoin (PHT), resulting in a decrease in the serum PHT level. UFT (not an abbreviation) is a mixture of uracil, which enhances the activity of 5-fluorouracil (5-FU), and tegafur, a masked compound of 5-FU. The authors report three cases in which treatment of malignant brain tumors with UFT caused acute PHT intoxication. Two patients received PHT preoperatively at 150-200 and 270 mg/day, and showed serum PHT levels of less than 5 micrograms/ml. The third patient was started on 150 mg/day of PHT after surgery. Postoperatively, in addition to radiation therapy, each patient received 4 capsules of UFT (each containing 100 mg of tegafur) per day. Their serum PHT levels peaked at 48.2, 30.9, and 24.2 micrograms/ml, and all three exhibited clinical symptoms of acute PHT intoxication. The mechanism of interaction of these two drugs is obscure. Tegafur may compete with PHT in binding to metabolic enzymes in the liver and/or directly suppress PHT metabolism, leading to an increase in the serum PHT concentration. Therefore, when PHT is given in combination with a masked compound of 5-FU, the serum PHT level should be closely monitored.

Adult↗
PubMed1990

[Agenesis of the right internal carotid artery with intracerebral hemorrhage: case report].

A 45-year-old woman was admitted to our department because of intracerebral hemorrhage. Neurological examination showed upward gaze palsy, right hemihypesthesia including face and nuchal rigidity. CT scan demonstrated a high density spot in the left quadrigeminal plate. Postcontrast CT scan demonstrated an abnormal vessel in the left midbrain. We suspected the presence of an arterio-venous malformation (AVM) and angiography was performed. Left vertebral angiography demonstrated early filling as far as the basal vein of Rosenthal with the contrast medium. However, no nidus suggesting AVM was observed. The right middle cerebral artery was fed via an anastomotic vessel (anomalous posterior communicating artery) from basilar bifurcation. Right carotid angiography demonstrated only the right external carotid artery indicating the absence of the right internal carotid artery. The bone target image of thin slice CT scan of the cranial base also disclosed the absence of the right carotid canal. 123I-IMP SPECT demonstrated no hypoperfusion area in the right cerebral hemisphere. The usefulness of the thin slice CT scan in the cranial base was discussed.

Carotid Artery, Internal↗
PubMed1989

Peptidergic innervation of the temporomandibular disk in the rat.

The peptidergic innervation of the temporomandibular disk was investigated in the postnatal young rat by using an indirect immunofluorescence method. Calcitonin gene-related peptide-containing nerve fibers were located around the blood vessels and terminated as free nerve endings in the disk. These nerve fibers may be of a sensory nature.

Aging↗
PubMed1989

Amnesia due to bilateral hippocampal glioblastoma. MRI finding.

The authors report a unique case of glioblastoma which caused permanent amnesia. Magnetic resonance imaging showed the lesion to be limited to the hippocampal formation bilaterally. Although glioblastoma extends frequently into fiber pathways and expands into the opposite cerebral hemisphere, making a "butterfly" lesion, it is unusual for it to invade the limbic system selectively to this extent.

Amnesia↗
PubMed1989

Localization of two distinct acid phosphatases in secretory ameloblasts of rat molar tooth germs.

Acid phosphatases were examined histochemically at the light- and electron-microscopic levels using para-nitrophenyl phosphate (pNPP) and beta-glycerophosphate (beta-GP) as substrates. By light microscopy, there was intense activity with pNPP in supranuclear and distal regions of the secretory ameloblast, and moderate or slight activity respectively in those regions with beta-GP. These enzyme activities were less at the late secretory stage of amelogenesis and disappeared at the transitional stage. By electron microscopy, acid phosphatase activity was seen in the trans side cisternae of the Golgi apparatus, in lysosome-like granules, and in small vesicles in the Tomes' processes. The activity with pNPP but not beta-GP was also localized at the plasma membrane (proximal, lateral and distal surface). Activity with beta-GP was completely inhibited by 1 mM sodium tartrate and by 1 mM NaF; activity with pNPP was inhibited by 1 mM NaF and 10 mM sodium tartrate, but not by 1 mM sodium tartrate. Thus there are at least two different acid phosphatases, one tartrate-sensitive and the other 1 mM tartrate-resistant, in the secretory ameloblast; the tartrate-resistant enzyme is plasma-membrane bound.

Acid Phosphatase↗
PubMed1989

Immunohistochemical observation on neuropeptides around the blood vessel in feline dental pulp.

Recent advances in immunohistochemistry have revealed the distribution of various neuropeptides in several mammalian dental pulps. These neuropeptides are substance P, neurokinin A, calcitonin gene-related peptide, vasoactive intestinal polypeptide, and neuropeptide Y. Nerve fibers showing immunoreactivity for these neuropeptides are mainly localized around the pulpal vessels, but some are apart from the blood vessel. The distribution of substance P-, neurokinin A-, and calcitonin gene-related peptide-containing nerve fibers is very similar; it appears that these three neuropeptides may be contained in the same nerve fibers. Denervation experiments indicate that substance P-, neurokinin A- and calcitonin gene-related peptide-containing nerve fibers originate from the trigeminal ganglion and that neuropeptide Y-containing nerve fibers come from the superior cervical ganglion. However, the exact origin of vasoactive intestinal polypeptide-containing fibers still remains unknown. These immunohistochemical data indicate that neuropeptides localized around the blood vessel may play a significant role in the regulation of the blood flow in the dental pulp.

Animals↗
PubMed1989

Histochemical localization of calcium in the enamel organ of rat incisors in early-stage amelogenesis.

The localization of calcium in the enamel organ of rapidly-frozen, freeze-substituted rat incisors in early-stage amelogenesis was examined by a histochemical calcium-staining method. In secretory ameloblasts, glyoxal bis(2-hydroxyanil) (GBHA) staining revealed intense red reactions in mitochondria and tubulovesicular structures located throughout the cytoplasm, while no reaction was seen in the nucleus and cytosol, nor along the plasma membranes of the respective cells. No significant GBHA reaction was observed in the intercellular compartment and other cells of the enamel organ. Some granular reactions were localized in the cells of the adjacent connective tissue. Control tests confirmed the specificity of GBHA reactions for calcium. Thus, the present observations provide histochemical evidence indicating an exclusive localization of calcium in mitochondria and tubulovesicular structures of the secretory ameloblast, and support their contributions to the translocation of calcium from the proximal to the distal pole of the cytoplasm.

Amelogenesis↗
PubMed1989

Meningioma of the fourth ventricle--case report.

A 58-year-old female had a 1-year history of headache, ataxia, and taste disturbance and then developed speech disturbance. She was found to have a meningioma of the fourth ventricle, a very rare site for this type of tumor. It did not adhere to the cerebellar tentorium or dura mater and was totally removed without difficulty. Magnetic resonance imaging, but not computed tomography or angiography, provided adequate information for correct diagnosis. The literature concerning fourth ventricle meningiomas is reviewed and the diagnostic advantages and limitations of computed tomography, angiography, and magnetic resonance imaging are discussed.

Cerebral Ventricle Neoplasms↗
PubMed1989

Paraplegia caused by brown tumor in primary hyperparathyroidism. Case report.

A brown tumor is a secondary disorder of bone associated with hyperparathyroidism that arises predominantly in the metacarpals, phalanges, jaw, pelvis, or femur. Rarely does this tumor involve the spine. The authors describe a case of brown tumor in primary hyperparathyroidism, causing spinal cord compression. The first step in diagnosing this lesion in an unusual site is a high index of suspicion. Essentially, this tumor is benign but emergency surgery for tumor removal is recommended in patients showing acute spinal cord compression.

Bone Diseases↗
PubMed1989

[Brain metastases from carcinomas of the digestive organs--a comparative study with those from pulmonary carcinomas].

During the past 11 years, we have experienced 7 cases of a metastatic brain tumor with the primary lesion in the digestive organs. Their clinical courses were retrospectively compared with those of 19 cases with a brain metastases from pulmonary carcinomas. Leptomeningeal carcinomatosis was found in 2 patients of the former group but none in the latter. Six out of 7 brain metastases in the former group were found to have averaged 13 months before their appearance after the diagnosis of the primary lesion. In contrast, 14 out of 19 patients in the latter group had an onset with symptoms of a brain metastasis. The average survival after intracranial surgery on the metastatic tumor was 174 days for the former group and 268 days for the latter. The prognosis of a brain metastasis from a carcinoma of the digestive organ appears to be extremely probable.

Adult↗