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Biomedical subjects

S W Weiss

Publications and source records attributed to S W Weiss.

112 records · Page 7Linked to original sources
PubMed1973

Amyloid nephropathy of Ostertag with special reference to renal glomerular giant cells.

The pathology of an unusual form of nonneuropathic familial amyloidosis is presented. The disease, occurring in two sisters, is similar to a form of familial amyloidosis described by Ostertag in 1950 and is characterized by progressive renal failure and an autosomal dominant mode of inheritance. Widespread vascular amyloidosis and dense renal glomerular amyloid deposits characterize the disease pathologically. Renal interstitial foam cells and glomerular giant cells were found in the kidneys of one sister. The giant cells, probably of macrophage origin, contain amyloid fibrils within poorly formed non-membrane-bounded cytoplasmic vacuoles. Transitions to well-formed membrane-bounded cytoplasmic vacuoles with nonfibrillar material were also present. It is suggested that these cells function to degrade and resorb amyloid, and that as amyloid is changed to a nonfibrillar state, well-defined membranes can form around the degraded material.

Amyloid↗
PubMedDate not supplied

Intramuscular myxoma: MR features.

Intramuscular myxoma is a benign mesenchymal lesion consisting of bland spindled cells embedded in an avascular myxoid stroma. On CT, intramuscular myxoma presents as a well-demarcated, homogeneous, low density mass situated within skeletal muscle. The attenuation of the lesion is slightly greater than water but less than that of the surrounding normal muscle, with typical values between +10 and +60 HU. There is scant magnetic resonance (MR) literature on the appearance of intramuscular myxoma; the few MR spin echo images that have been published characterize it as a homogeneous mass with signal intensity less than or equal to skeletal muscle on T1-weighted and brighter than fat on T2-weighted pulse sequences. We present two cases of intramuscular myxoma with imaging characteristics that differ from those previously reported.

Adult↗
PubMedDate not supplied

Ossifying fibromyxoid tumor of soft parts with stromal cyst formation and ribosome-lamella complexes.

Ossifying fibromyxoid tumor of soft parts (OFMT) is a recently named soft tissue tumor of uncertain nature. A case is described that presented in a 13-year-old boy as a discrete mass in the muscles of the lower abdominal wall. Light microscopy showed, in addition to the typical features of this entity, microcysts formed by accumulations of the myxoid stroma. Bone formation was lacking. Tumor cells were strongly immunoreactive for vimentin and glial fibrillary acidic protein and weakly so for S-100 protein. A few cells stained for desmin and alpha-smooth muscle actin. Ultrastructurally, there were abundant, patternless cytoplasmic intermediate filaments; short, poorly interdigitating processes; and discontinuous segments of thick external lamina. In addition, several cells contained typical ribosome-lamella complexes in small groups. Ribosome-lamella complexes occur in neoplastic hematopoietic cells but are uncommon in solid tumors, particularly those affecting the soft tissues. These findings extend the range of appearances described for OFMT, which is added to the list of tumors in which ribosome-lamella complexes have been demonstrated. The balance of evidence suggests that OFMT may represent a peripheral nerve sheath tumor of low-grade malignancy, although the picture is incomplete.

Adolescent↗