Search PubMed⌕ Search

Biomedical subjects

S W Redding

Publications and source records attributed to S W Redding.

52 records · Page 3Linked to original sources
PubMed1986

The incidence of oral herpes simplex virus infection in patients undergoing cancer chemotherapy.

Oral lesions in twenty-nine immunocompromised patients were evaluated for the incidence of herpes simplex virus (HSV) infections during either cancer chemotherapy or cancer chemotherapy plus bone marrow transplantation (BMT). Patients' HSV antibody titers were not determined, and positive diagnoses were based solely on the results of viral cultures. Fourteen patients (48%) were found to have herpetic infections, which is comparable with incidence rates of 50% to 90% in antibody-positive patients and 40% to 50% in mixed antibody populations reported in the medical literature. However, this finding is in conflict with the 10.7% to 15.1% incidence rate cited in the dental literature for patients undergoing cancer chemotherapy. This underestimation is believed to reflect insensitivity in the criteria used for diagnosis in these studies.

Antibodies, Viral↗
PubMed1985

Relative value of screening tests of hemostasis prior to dental treatment.

Identification of potential bleeders is very important prior to any dental treatment. One hundred fifty-three adult patients in the screening population at a dental school were examined by medical history and by determinations of prothrombin time, partial thromboplastin time, and bleeding time to determine if those patients with a negative bleeding history had a significant percentage of elevated laboratory values. This study was performed to see if these three tests would be of value in screening this population for bleeding disorders. The results suggest that proper medical history taking will identify a majority of potential bleeders and that these three tests are of little value in this population.

Adult↗
PubMed1983

Dental management of the classic hemophiliac with inhibitors.

Approximately 15 percent of patients with hemophilia A will develop inhibitors (antibodies) to Factor VIII after replacement infusion. Since Factor VIII replacement therapy is the mainstay of treatment in the hemophiliac, destruction of infused Factor VIII by inhibitors presents significant problems in the treatment of these patients. Different methods of treatment are discussed, including infusion of high doses of Factor VIII and infusion of prothrombin-complex concentrate. Two inhibitor patients who presented for dental treatment are examined. One patient had very low inhibitor titers, and the other had very high inhibitor titers. These patients show that dental treatment must be individualized according to severity of the disease process.

Adult↗
PubMed1981

Gardner's syndrome: report of case.

This case graphically illustrates the dental clinician's role in the diagnosis of Gardner's syndrome. Findings in the head and neck in this case led to discovery of the disease. Because of the high incidence of malignant transformation, surgery of the lower intestinal tract is done to remove any polypoid lesions. Normal-appearing tissue from which carcinoma might arise is also removed. Because of the usual occurrence of head and neck lesions in Gardner's syndrome, the clinician can make a major contribution in the diagnosis of this uncommon, but important, disease.

Adult↗
PubMedDate not supplied

Oral herpes simplex virus infection with cardiac transplantation.

Oral herpes simplex virus infection is a common complication of cardiac transplantation. Lesions are secondary to reactivation of the virus, are atypical in appearance, and can involve any oral and perioral surface. Diagnosis on clinical grounds is difficult and should be confirmed with laboratory testing. A case report and review of the literature are presented to support the features of this infection.

Adult↗
PubMedDate not supplied

A comparison between fluconazole tablets and clotrimazole troches for the treatment of thrush in HIV infection.

Fluconazole, a newly available triazole, has been evaluated extensively as a treatment for thrush. It has been effective in the treatment of this condition in patients with HIV infection. Clotrimazole troches have been a common treatment for thrush in patients with HIV infection for several years. This study compared the efficacy and safety of fluconazole 100 mg tablets once per day versus clotrimazole 10 mg troches five times per day in the treatment of thrush in patients with HIV infection. Patients were evaluated at baseline, day 7, 14, 28, and 42. The following parameters were evaluated: clinical cure, colonization at the end of treatment, relapse at day 28, and relapse at day 42. Side effects including liver enzyme values were also monitored. Clinical cure was superior with fluconazole tablets than with clotrimazole troches. Also, rates of colonization at the end of therapy and relapse at days 28 and 42 were less with fluconazole tablets than with clotrimazole troches. However, these differences were not statistically significant. Patient compliance with fluconazole was superior to that of clotrimazole. This difference was statistically significant. Both fluconazole tablets and clotrimazole troches are effective in treating thrush in patients with HIV infection. The avoidance of multiple-per-day dosing would appear to favor fluconazole.

AIDS-Related Opportunistic Infections↗
PubMedDate not supplied

The epidemiology of non-albicans Candida in oropharyngeal candidiasis in HIV patients.

Oropharyngeal candidiasis (OPC) is the most common fungal infection in patients with HIV infection. Fluconazole has been proven to be very effective in treating this infection, but decreased susceptibility of Candida to this drug has emerged. Certain non-albicans species such as C. glabrata and C. krusei are commonly less susceptible to fluconazole than C. albicans and are being isolated with increased frequency in HIV patients. The purpose of this study was to determine if the presence of non-albicans Candida with OPC in HIV patients had an impact on clinical presentation. This study shows that late-stage HIV patients have a high prevalence of Candida with decreased susceptibility to fluconazole, especially non-albicans species. OPC episodes with non-albicans isolates were more likely to require higher doses of fluconazole to achieve clinical cure. Also, the presence of non-albicans Candida was more frequently associated with severe symptoms.

AIDS-Related Opportunistic Infections↗
PubMedDate not supplied

Dental management of children with asthma.

Asthma affects about 1 in 10 children. The condition is characterized by acute respiratory distress brought on by environmental factors. The condition is treated with medications aimed to reduce reaction to stimulants by the airway. Dental management involves attention to the status of the patient and awareness of stimulants of the reactive airway. Clinical recommendations are provided.

Acute Disease↗