Search PubMed⌕ Search

Biomedical subjects

S W Rasmussen

Publications and source records attributed to S W Rasmussen.

36 records · Page 2Linked to original sources
PubMed1993

External compression of forearm nonunion. A report on 6 cases.

We treated 6 patients with 7 cases of aseptic nonunion of the forearm with external fixation and compression (Orthofix) without open reduction and bone grafting. By turning a screw on the side of the bar, compression was carried out until the nonunion gap with radiographically obliterated, usually within 2 weeks. After compression had stopped, the external fixator was retained during the following period of healing and bone remodeling. Healing of the nonunions was seen after 7 (4-11) weeks. 5 patients obtained normal mobility, while 1 had slightly restricted supination and pronation.

Adolescent↗
PubMed1992

[Emergency services in the admission department of a central hospital].

Medical treatment during the evening and night hours has been the subject of debate at present on account of changes in the practitioner-on-call system. The emergency medical service in the catchment region for the Central Hospital in Naestved before these changes was therefore analysed. Services rendered in this region outside working hours, both by the physician-on-call and the hospital, were registered for the period 1.12.1989-31.1.1990. A total of 8,742 consultations occurred during the period, viz every tenth member of the population sought medical advice. The majority of these contacts were with the practitioner-on-call as 7,253 (83%) sought their general practitioner first and the remainder came to hospital. This corresponds to 117 consultations with the practitioner-on-call and 22 visits to the casualty department per 24 hours of emergency service. Among the patients seeking help from the casualty department, it was found that 30% could have been treated in general practice. Among the taks for the practitioner-on-call, there were 27% telephone consultations, 21% in practice and 52% home visits. No differences were observed between urban rural regions as regards the proportions of services but the number of services followed population percentages. 11% sought medical help at night and 1/3 of these patients were referred to hospital. In the present material, there appeared to be relatively great misuse of the telephone number 000 (equivalent to 999) as only 1/3 of these patients were admitted to hospital. A total of 1,263 patients were admitted to hospital and 78% (982) of these had been seen primarily by the practitioner-on-call.(ABSTRACT TRUNCATED AT 250 WORDS)

Denmark↗
PubMed1992

Transfusion associated bacteremia and septic shock due to Erwinia herbicola.

We report a case of severe septicemia after blood transfusion to a 61-year-old man. The patient developed septic shock with signs of disseminated intravascular coagulation already during the blood transfusion. Blood culture from the patient showed growth of Erwinia herbicola and culture from the blood bag massive growth of the same microorganism. The bag had been stored in a refrigerator for 3 weeks after tapping. It is likely that contamination occurred during the tapping procedure.

Bacteremia↗
PubMed1986

Chromosome interlocking during synapsis--a transient disorder.

The occurrence and resolution of chromosome interlocking have been monitored during chromosome pairing on 270 zygotene and 125 pachytene spread and silver stained chromosome complements from Bombyx spermatocytes. Interlockings form and resolve throughout zygotene. The estimated mean number of interlockings is 4.2 per nucleus at zygotene while only 3 presumptive interlockings were found in 125 pachytene nuclei. In individual zygotene nuclei up to 61% of the chromosomes are affected by interlocking. The mechanism for resolution of interlockings is discussed.

Animals↗
PubMed1985

Nosocomial acute gastroenteritis in a paediatric department, with special reference to rotavirus infections.

Nosocomial acute gastroenteritis caused by rotavirus as well as by non-rotavirus gastroenteritis was registered during a 12-month period in the paediatric department of a district hospital. The number of patients in the two groups amounted to 27% (rotavirus) and 7% (non-rotavirus) of the total number of patients hospitalised with the corresponding type of acute gastroenteritis. The seasonal and age distributions for the two types of nosocomial acute gastroenteritis followed the pattern of the respective types of hospitalised community-acquired acute gastroenteritis. Nosocomial non-rotavirus gastroenteritis was found to occur scattered with regard to time and locality within the department. The same applied to one half of the cases with nosocomial rotavirus gastroenteritis, whereas the other half occurred during an epidemic outbreak in the general infant/toddler ward. Vomiting and diarrhoea were less significant in nosocomial rotavirus gastroenteritis as compared with community-acquired rotavirus gastroenteritis. As to the other manifestations no difference was found between the two groups. Nosocomial rotavirus gastroenteritis prolonged the stay in hospital with on the average 3.8 days. Guidelines are suggested for isolation of patients with acute gastroenteritis in order to reduce particularly the frequency of nosocomial rotavirus infections.

Acute Disease↗
PubMed1985

Clinical features in hospitalised children with acute gastroenteritis. Does the rotavirus syndrome exist?

In a prospective study of children referred to hospital, rotavirus was identified in 37% of 128 patients with acute gastroenteritis. As compared with patients with non-rotavirus gastroenteritis, those with rotavirus gastroenteritis showed the following clinical characteristics: Age between 5 months and 4 years. Occurrence of the rotavirus infection almost exclusively during the winter season. Severe vomiting. Absence of gross blood in the stools. However, these signs did not form a safe basis for the clinical diagnosis of rotavirus gastroenteritis. One or more signs of upper respiratory illness were observed in 36% of the patients with rotavirus gastroenteritis and in 35% of those with non-rotavirus gastroenteritis. Consequently, the existence of a rotavirus syndrome is questioned. It is argued that upper respiratory illnesses in patients with rotavirus gastroenteritis could be due to a separate infection occurring coincidentally.

Acute Disease↗
PubMed1984

The synaptonemal complex, recombination nodules and chiasmata in human spermatocytes.

Reconstruction from serial sections of 120 human spermatocyte nuclei, ranging in stage from leptotene to anaphase I, has led to the following conclusions. The reconstructed nuclei form a continuous sequence of developmental stages. With few exceptions, all of the bivalents are identifiable by length, centromere index and morphological markers. Crossing over is accompanied by a transformation of the recombination nodule (RN) into a fusiform bar lying across the synaptonemal complex (SC). The evolution of the crossover distribution at late pachytene is regulated at two levels both involving the SC. Each bivalent displays a pattern of SC regions - domains - with high affinity for RNs in the middle and low affinity at the ends. The occurrence of crossing over in a domain reduces the probability of attachment of new RNs and causes RNs not yet involved in crossing over to be released from that domain. Positive interference between crossovers is a consequence of these phenomena. At diplotene the degradation of the SC is initiated in regions with low affinity for RNs and small segments of the SC are retained at the crossover sites until late diakinesis. The site of crossing over is only identifiable by an RN for a certain period of time during pachytene. The distribution of total crossovers in a nucleus is similar but not identical to the distribution of chiasmata as seen in the light microscope. The number of crossovers has been estimated to be 70 and exceeds the number of chiasmata determined by light microscopy by a factor of 1.4.

Animals↗
PubMed1982

Ultrastructural characterization of the meiotic prophase. A tool in the assessment of radiation damage in man.

The three-dimensional reconstruction of meiotic nuclei from serial sections micrographed in the electron microscope has provided information about man and several other organisms that is not obtainable by light microscopy or biochemical analysis. At zygotene, the previously unpaired chromosomes align and form synaptonemal complexes between homologous chromosome segments either by progressive initiation from the telomeres or by interstitial recognition. Chromosome and bivalent interlocking at zygotene is a regular phenomenon and occurs at a frequency of 0.7-4.0 per nucleus in samples of meiocytes analyzed from different organisms. This frequency is reduced to 0.1 per nucleus at pachytene. The interlockings are resolved by breakage and precise rejoining of the broken ends. This breakage and rejoining can also occur in the absence of the DNA nicking and repair involved in crossing-over. The synaptonemal complexes combining homologous chromosome segments are stabilized by recombination nodules, after which a second round of synaptonemal complex formation between as yet unpaired or unstably paired chromosome segments occurs, apparently for optimization of bivalent formation. Non-homologous pairing with the synaptonemal complex can take place in this phase of pachytene. Continuity between recombination nodules and chromatin chiasmata has been traced at the ultrastructural level but not all nodules lead to chiasmata. The distributions of recombination nodules among the bivalents and along the bivalents at successive stages of meiotic prophase show that the nodules are placed at random at early-zygotene after which bivalents without nodules have preference for the acquisition of these structures. Chiasma interference appears as a consequence of the limited number of recombination nodules available together with a decreased affinity of a bivalent arm with a nodule for additional ones. The relevance of these observations in the study of genetic damage by radiation is discussed.

Aneuploidy↗
PubMed1977

The transformation of the Synaptonemal Complex into the 'elimination chromatin' in Bombyx mori oocytes.

In Bombyx mori oocytes the synaptonemal complexes are retained in modified from pachytene to metaphase I. At the end of pachytene the length and width of the lateral components of the complex increase, whereafter the complexes become compacted during later stages of the meiotic prophase. Ultimately, at metaphase I the modified synaptonemal complexes of individual bivalents fuse to form a more or less continuous sheet between the homologus chromosomes. This sheet corresponds to the structure historically known as the 'elimination chromatin'. It is concluded that in the absence of crossing over and chiasma formation in Bombyx mori females the retainment and subsequent modification of the synaptonemal complex has evolved as a substitute mechanism to ensure regular disjunction of the bivalents.

Animals↗
PubMed1977

Meiosis in Bombyx mori females.

Crossing over is absent in oocytes of the silkworm, Bombyx mori. Synaptonemal complexes are present during pachytene between the paired chromosomes. At leptotene, lateral components of the synaptonemal complex are attached in a bouquet to a limited region of the nuclear envelope. Before completion of lateral components, synaptonemal complex formation begins at the nuclear envelope. With synaptonemal complex formation proceeding from both ends bivalents occasionally become interlocked. After pairing is completed, the bouquet arrangement is dissolved possibly as a result of a flow of the inner membrane of the nuclear envelope thereby separating the telomeres. After the telomeres are released from the nuclear envelope, material is deposited onto the lateral components of the synaptonemal complex. The modified synaptonemal complexes are retained by the bivalents until metaphase I. It is suggested that these modified synaptonemal complexes substitute for chiasmata in order to ensure regular disjunction of homologous chromosomes in the absence of crossing over.

Animals↗
PubMed1976

The meotic prophase in Bombyx mori females analyzed by three dimensional reconstructions of synaptonemal complexes.

Serial sectioning followed by three dimensional reconstruction of lateral componenets of the synaptoemal complex have been used to follow chromosome pairing during theprophase of the achiasmatic meiotic division in the silkworm. Bombyx mori. During leptotene and early zygotene, the lateral components become attached to the nuclear envelope at a specific region, thus forming a chromosome bouquet. The attachment of lateral componenets to the nuclear envelope precedes the completion of the components between their attachment points. Synapsis and synaptonemal complex formation start during the period of lateral component organization in the individual nucleus. Telomeric movements on the nuclear envelope occur at two stages of the prophase: the chromosome pairing appears to be initiated by an association of unpaired ends of homologus chromosomes, the nature of this primary attraction and recognition being unknown. Secondly, the paired chromosomes become dispersed in the nucleus by shifting of attachment sites of completed synaptonemal complexes at the end of zygotene. This movement is possible related to a membranes flow occuring during this stage. Membrane material is synthesized at the region of synaptonemal complex attachment. Later, the excess membrane material is shifted to the opposite pole where it protudes into the lumen of the nuclei thus forming vacuoles. Two previously undescribed features of chromosomes paring were revealed. In late zygotene, chromosome pairing and synaptonmal complex formation were frequently observed to be delayed or even prevented over s short distance by interlocking two bivalents, both being attached to the nuclear envelope. Such interlocking of bivalents was not found in pachytene...

Animals↗