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Biomedical subjects

S W Khan

Publications and source records attributed to S W Khan.

6 recordsLinked to original sources
PubMed2002

Prevalence of hearing impairment in siblings of deaf children.

OBJECTIVE: To assess the prevalence of hearing impairment in siblings of children with profound to total hearing impairment. METHOD: Two hundred and twenty siblings of children at a deaf school in Karachi completed the screening program. This consisted of a questionnaire and pure tone audiometry. RESULTS: One out of three (73 siblings) had a threshold of 25 dB or greater in their better ear. In a population, already aware of hearing loss, we note that only fifteen siblings had a previous audiogram. Although a positive family history is associated with hearing impairment in the siblings, no increase due to consanguineous marriages was noted. CONCLUSION: This assessment has underlined the need to increase public awareness of hearing impairment. It has also exposed the lack of it in families exposed to the condition.

Adolescent↗
PubMed2001

Uropathogens and their susceptibility pattern: a retrospective analysis.

OBJECTIVE: To determine the frequency and antibiotic susceptibility pattern of uro-pathogens. SETTING: Department of Pathalogy, Ziauddin Medical Hospital Laboratory, Karachi. METHOD: A retrospective analysis was done on all the urine samples sent for culture and sensitivity during a seven months period. Two thousand eight hundred and forty four urine samples were received and inoculated in cysteine lactose electrolyte deficient agar (CLED). Positive samples were identified, processed and antibiotic susceptibility was carried out. Data was analyzed using Microsoft Excel 97. RESULTS: E. coli (45.6%) was the leading uropathogen followed by candida spp. (10.5%), enterococcus spp. (10.2%). For E. coli ampicillin, ceftazidime, nitrofurantoin and gentamycin sensitivity was 26%, 20%, 79.5%, 65% respectively. Enterococcus isolates showed 60% resistance to ampicillin. CONCLUSION: The resistant pattern of uro-pathogens causing urinary tract infections to common antimicrobial agents is changing and must be taken into account when selecting treatment strategies. Therefore, antibiotic policy should be made according to local surveillance data.

Drug Resistance, Microbial↗
PubMed1993

Epidemiology of salmonellosis and its sensitivity in Karachi.

Over the past five years 25,000 blood cultures were screened for septicaemia. Of these 6.7% were positive for salmonella species, the commonest being salmonella typhi accounting for 92% of total salmonella isolates. Over the years, S. typhi showed a gradual decline ranging from 96.7 to 87%. While salmonella paratyphi A has shown a gradual increase ranging from 2.5% to 11.4%. Salmonellosis peaked in the year 1990 suggesting an epidemic. The antibiotic sensitivity pattern showed a gradual increase in resistance over the years and even resistance to the new quinolones has emerged. Thus salmonellosis poses a major threat to the community and we must look into the alternative antibiotics to combat the threat.

Bacteremia↗
PubMed1993

Significance of thyroid microsomal antibody in Graves' disease.

Thyroid microsomal antibody (MsAb) was estimated in 48 patients with Graves' disease (15 newly diagnosed, 15 on drugs for about 4 weeks and 18 euthyroid with drug treatment) and twenty age and sex matched controls. The diagnosis of Graves' disease (GD) was based on clinical history, physical examination and thyroid function tests, viz. 131I uptake, thyroid scintigram and serum T3, T4 and TSH levels. MSAb was positive in 93.3% of newly diagnosed as well as hyperthyroid GD patients on drugs. Eighty-three percent euthyroid GD patients and 20% normal controls also showed MSAb positivity. The titres of newly diagnosed patients were significantly raised (P < 0.05) than those of euthyroid patients and controls indicating the diagnostic as well as prognostic significance of MSAb in Graves' disease.

Adolescent↗