Biomedical subjects
S W Jordan
Publications and source records attributed to S W Jordan.
Carcinoma of the cervix in American Indian women.
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Ultrastructural pathology of murine pneumonitis caused by K-Papovavirus.
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[Cervix uteri cancer control program].
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Ultrastructural studies of spleen after whole body irradiation of mice.
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Testicular changes in atomic bomb survivors.
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Fine needle aspiration cytology of malignant spiradenoma arising in congenital eccrine spiradenoma.
The fine needle aspiration (FNA) cytology of malignant eccrine spiradenoma arising in a large benign congenital eccrine spiradenoma is described. The malignant tumor was characterized by cohesive, pleomorphic cells with malignant nuclear features and numerous mitoses. FNA of the adjacent benign eccrine spiradenoma revealed prominent basement membrane deposition with an irregular tubular and nesting growth pattern and bland basaloid cells. To our knowledge, the FNA of malignant eccrine spiradenoma has not been previously described. In this case, FNA cytology was influential in directing patient management.
Cytologic detection of penile malignant melanoma of soft parts in pleural effusion using monoclonal antibody HMB-45.
A case of penile malignant melanoma of soft parts ("clear cell sarcoma") with pulmonary metastases and malignant effusions is reported. The tumor cells in the pleural effusion were scattered singly and admixed with reactive mesothelial cells. They had abundant granular cytoplasm and round nuclei with prominent nucleoli. Although staining for S-100 protein was positive in sections from the penile lesion, it was negative in sections of a cell block prepared from the effusion; however, the effusion tumor cells demonstrated immunoreactivity with HMB-45, an antimelanoma monoclonal antibody.
Association of human papillomavirus and Chlamydia infections with incidence cervical neoplasia.
Incidence cervical neoplasia is defined as disease that becomes manifest during a given period of observation. Association with preceding genital infections having characteristic cytologic findings would seem to be more likely for incidence than for prevalence cases since the usual long latency period of carcinoma in situ (CIS) could allow resolution of infectious processes. For this reason, it was elected to examine the preceding Papanicolaou smears from patients with tissue-confirmed incidence CIS or invasive epidermoid carcinoma. There were 67 women with biopsy-proven CIS or invasive carcinoma of the uterine cervix identified in the files of the University of New Mexico Cytopathology Laboratory from 1966 to 1982 who had two initial negative smears as well as smears at intervals of three years or less. All cytologic smears prior to tissue diagnosis were rescreened for confirmation of cytologic atypia or its absence as well as for morphologic evidence of human papillomavirus (HPV) or chlamydial infections. Control cases matched for age, gravidity, ethnicity and number of smears were reviewed in an identical manner. Koilocytes indicative of HPV infection were found in 17 index cases (25%) and 5 controls (7%) (p = 0.005). Chlamydial infections were identified in 18 index cases (27%) and in 4 controls (6%) (p = 0.001). The times required for conversion from smear negativity to malignancy were determined for each incidence case. The results showed great variability but suggest that the progression to malignancy is not hastened in women with antecedent HPV or chlamydial infections. Our results indicate that the presence of koilocytes and/or chlamydial inclusions in cervical smears serves to identify a group of women with a significantly increased risk of developing cervical carcinoma, even in the absence of concurrent dysplasia.
Ethnic distribution of cytologically diagnosed herpes simplex genital infections in a cervical cancer screening program.
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The significance of cervical cytologic dysplasia.
The cytologic screening experience of the University of New Mexico Cytopathology Laboratory was reviewed for a nine-year period in order to evaluate the potential for progression of cervical squamous dysplasia to severe dysplasia and carcinoma. Entry conditions for dysplasia study were two initial negative smears in order to standardize the cytologic history to a reasonable extent. Relative likelihood of progression was calculated for three levels of cytologic dysplasia and was compared to those of negative and positive smears in order to ascertain the relative risk of the various levels of cytologic atypia. Slight, moderate an severe dysplasia were, respectively, 9.0, 26.3 and 83.3 times more likely than a negative smear to be followed by one positive for carcinoma or showing severe dysplasia. Histologic follow-up of study subjects was correlated with their cytologic history. Cytologic follow-up of patients with slight, moderate and severe dysplasia indicated a high spontaneous regression rate. Time for conversion from negative cytology to severe dysplasia or positive cytology for histologically confirmed cases averaged 3.0 years. An unexpected finding was a 12.5% false-negative rate for severe dysplasia and positive cytology, indicating a need for caution in advising repeat smears in lieu of a biopsy for confirmation of these findings.
Selected characteristics of cervical cancer incidence cases.
Selected demographic characteristics associated with incidence cases of uterine cervical squamous severe dysplasia and carcinoma were determined. The mean age at histologic detection for all patients with Papanicolaou smears at not greater than three-year intervals was 31.0 years, with a range of 19 to 63. Invasive carcinomas were predominantly of the microinvasive type, and the mean age of patients was 34.1 years. The mean interval for conversion from cytologic negativity or mild dysplasia was 2.2 years, and two basic patterns of conversion were recognized: (1) continuously increasing atypia and (2) retrogressive cytologic findings. Most instances of the latter type probably were due to inadequacies of cellular sampling. No significant correlation was found between conversion interval and age of patient. A case-control comparison of gravidity and parity showed statistically significantly higher values among index cases for both measures for ages 20 to 29 but not for 30 years or older, implicating youthful pregnancy as an etiologic factor in cervical carcinogenesis.