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Biomedical subjects

S W How

Publications and source records attributed to S W How.

At least 37 records · Page 2Linked to original sources
PubMed1991

Atypical myxoma.

We report the case of a 38-year-old woman with a large thin-walled cystic mass (6 x 5 x 4.5 cm) filled with arterial blood in the right atrium. The cystic mass with blood content was clearly delineated by transesophageal cross-sectional echocardiography and magnetic resonance imaging of the heart. At operation, a silver-whitish, smooth surfaced cystic mass was found attached to the free wall of the right atrium between the superior vena cava and the right atrial appendage with a broad base. Microscopically, the wall of the cyst was composed of stellate mesenchymal cells embedded within a myxoid matrix which was proved by alcian blue stain. To our knowledge, this type of cardiac myxoma has not been previously reported.

Adult↗
PubMed1991

Primary malignant tumor of the small intestine.

The records of 101 patients with primary small intestinal malignant tumor at NTUH, collected from 1960 to 1989, were reviewed. These patients represented 1.2% of the patients with gastrointestinal cancer at NTUH over the same period. Fourty-two (41.6%) of the cancer patients had lymphomas, 30(29.7%) had adenocarcinomas, 26 (25.7%) had leiomyosarcomas, and 3(3.0%) had carcinoid tumors. The average age at cancer presentation was 47.5 years (range from 3 to 96). The lymphoma patients had an average age of 35.1 years, while adenocarcinoma patients averaged 60.4 years of age. Leiomyosarcoma and carcinoid tumors averaged 51.2 years and 59 years, respectively. There were 65 male patients and 36 female patients, and there was a male predominance in all groups except for the leiomyosarcoma group which had an equal sex ratio. Generally speaking, the incidence rate for the areas involved were similar in the duodenum, jejunum and ileum. However, adenocarcinomas were more common in the duodenum (53%) and 45% of lymphomas were found in the ileum, as were the carcinoid tumors (66%). The most common presenting symptom was abdominal pain (62%), with bleeding second (32%). Obstruction and palpable mass together were present in 29% of the cases. Body weight loss was found in 25% of patients, and 14% of the patients presented with acute abdomen due to intestinal perforation. Laparotomy was the most common diagnostic procedure (60%). Preoperative diagnoses were possible in cases of duodenal and upper intestinal malignancies, but were rarely possible in patients with lower intestinal malignancies. Sixty-eight patients (68%) underwent tumor resection for palliation or cure. The operation mortality was 4%.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1991

Coefficient of variation of nuclear diameters as a prognostic factor in papillary thyroid carcinoma.

To determine whether the coefficient of variation (CV) of nuclear diameters can be used as a prognostic factor in papillary thyroid carcinoma, we reviewed fine needle aspiration smears with Riu's stain from 55 operated-on and pathologically verified cases with a median follow-up of 6.5 years. For each case we measured the nuclear diameters of 100 cancer cells by ocular micrometry and calculated the CV of the nuclear diameters. Then we correlated the CV with the clinical stage, recurrence and death. There was a positive correlation between the CV of the nuclear diameters and the clinical stage (r = .59, P less than .0001). Recurrent cases (n = 10) had a higher CV than did those without recurrence (n = 45) (18.04 +/- 4.1% [mean +/- SD] versus 13.2 +/- 2.7%, P less than .0005). All recurrent cases had a CV greater than 13%. The cases in which death occurred (n = 5) had a higher CV than did those with survival (n = 50) (20.1 +/- 4.9% versus 13.5 +/- 2.7%, P less than .0005). All cases in which death occurred had a CV greater than 15%. The extent of variation of nuclear diameters was one of the factors influencing prognosis in papillary thyroid carcinoma. It offers a prognostic adjunct to standard clinical and histologic analysis.

Adult↗
PubMed1990

Familial medulloblastoma in siblings: report in one family and review of the literature.

Two siblings in a family--a 5-year-old boy and an 8-year-old girl--suffered from progressive headache and gait disturbance in an interval of 1 year, consecutively. Neurologic manifestations were papilledema and truncal ataxia. Both of their computed tomography scans showed a large, well-enhanced tumor located in the cerebellar vermis with secondary hydrocephalus. Both had surgical resection followed by craniospinal irradiation and then chemotherapy. The pathologic findings confirmed the diagnosis of medulloblastomas. The family pedigree disclosed some other cancer in close relatives. These findings suggested a possible role of heredity in the oncogenesis of this tumor. To our knowledge, our cases are the seventh report of familial medulloblastoma occurring in nontwin siblings in the world.

Brain Neoplasms↗
PubMed1990

[Experimental hip dysplasia in the rabbit].

Neglected cases of congenital dislocation of the hip (CDH) always present with profoundly interesting X rays and pathoanatomical changes. Because of progressive dysplastic change, it is difficult to determine clinically at what stage a patient can not have reconstructive surgery. We used an animal model to induce hip dysplasia in order to understand the mechanism of dislocation and to demonstrate the dysplastic changes at various ages of dislocation. We used a plastic tube to immobilize the left knee of one week old New Zealand white rabbits in the extension position. Fifty-five rabbits in a natural history group were examined physically, radiographically and pathologically every month, until five months old. Ten rabbits were also studied by computed tomography before sacrifice. Forty-two rabbits which had been immobilized for more than 2 months were selected to determine the changes in their left hips. Tenotomy of the hamstrings of the left knee was performed in another 20 rabbits, which were then immobilized in the same way until 2 months old. The changes in their left hips were also determined and compared with the changes of former group. In our study, immobilization of the left knee of rabbits can induce dislocation, subluxation or no change. Tenotomy of the hamstrings can decrease the incidence of dislocation and subluxation, but cannot avoid their occurrence. In long-term observation of rabbits with dislocation and subluxation, we found that there are more dysplastic and degenerative changes in older rabbits. Computed tomography proved to be an effective evaluation tool of the size of dysplastic acetabulum and femoral head.

Animals↗
PubMed1990

The atrioventricular conduction axis of hearts with isolated ventricular septal defects.

We studied the surgical anatomy of 14 hearts with isolated ventricular septal defects and the precise relationship of the atrioventricular conduction axis to their rims. Ten of these hearts were investigated by serial sectioning of their atrioventricular conduction systems. All defects were divided into perimembranous or muscular types as previously suggested by Soto et al. The distinguishing feature of the perimembranous defect was that the central fibrous body formed part of its rim, this fact indicated that the conduction tissue was always to the right of the surgeon's hand when the defect was approached through the right atrium. The precise relationship of the ventricular conduction tissues varied depending upon whether the perimembranous defect extended into the inlet, trabecular or outlet components of the muscular septum. The nonbranching bundle was closest to the septal rim in the inlet and trabecular defects, frequently being buried in a remnant of the interventricular membranous septum. However, in these defects the nonbranching and branching bundles were also found in other specimens remote from the septal crest, yet were carried on the left ventricular aspect of the septum. In perimembranous inlet defects, the penetrating bundle detoured deep into the central fibrous body. In perimembranous outlet defects, the conduction tissues were remote from the septal crest. In contrast to these findings, the conduction tissues were away from the edges of the defects in trabecular and outlet muscular defects. In conclusion, in the perimembranous inlet defect, the placement of the sutures on the annulus of tricuspid valve should be avoided in view of its abnormal long penetrating bundle.

Atrioventricular Node↗
PubMed1990

Correlation between sonography and pathology in thyroid diseases.

Ultrasonography was performed on the thyroid glands of 47 patients with various thyroid diseases, in a fresh state, immediately following operation. The thyroid glands were then sectioned along the plane of the most significant sonographic changes. The pathologic changes of the sectioned plane were observed and compared with the sonographic changes. In nodular goiter, the sonographic changes were usually heterogeneous. The margin was either well-defined or ill-defined, and cystic changes might play a minor or major part in the thyroid nodules. In follicular adenoma, the changes were isoechoic in adenoma with embryonal type follicles and hyperechoic in adenoma with colloid type follicles. In adenoma of the oxyphilic cells, the echogenicity was somewhat greater in the hemorrhagic part compared to the area with oncocytic change only. In papillary carcinoma, the lesions usually manifested as well-limited, heterogeneous, hypoechoic nodules. Cystic degenerations were frequently noted. There were discrete particles corresponding to microcalcification in 4 out of 6 cases. In follicular carcinoma, the sonographic changes also showed well-limited nodules. However, the echogenicity was not decreased as much as in papillary carcinoma, and it could be either homogeneous and isoechoic, or hypoechoic. Relatively large particles with an acoustic sign, which corresponded to calcification, were noted in 2 out of 4 cases. In medullary carcinoma, the lesion was well-limited and hypoechoic. The particles present in sonography corresponded to calcification in the amyloid. In Graves' disease, the main sonographic change was a diffusely homogeneous, isoechoic or hypoechoic lesion. Cystic change was rarely present. Dispersed particles were rarely present and corresponded to fibrosis in the thyroid tissue.(ABSTRACT TRUNCATED AT 250 WORDS)

Goiter, Nodular↗
PubMed1989

Ischemic colitis as a cause of massive lower gastrointestinal bleeding and peritonitis. Report of five cases.

Vascular disorders of the colorectum are considered rare in Taiwan, however, recently the authors encountered five cases of ischemic colitis, all in men over 50 years of age. Cases one and five involved stricture, case two was secondary to obstructive colon cancer, and case three was of the gangrenous type presenting with peritonitis due to colonic perforation. Case four was of the transient type with acute massive lower gastrointestinal bleeding secondary to traumatic shock. All five patients were treated successfully by resection.

Aged↗
PubMed1989

Is the sinus node visible grossly? A histological study of normal hearts.

The sinus node is said to be occasionally visible in the human heart, while some have denied this visibility. This histological study of the normal sinus node was made on 11 adults and 10 infants. The node was always located subepicardially along the terminal groove at the junction of the superior caval vein and the right atrium. When no fatty infiltration (all infants and 2 adults) or minimal fatty tissue (2 adults) was found over the epicardial side of the node, it was not visible grossly. When fatty infiltration was obvious, then the node could be identified grossly as a yellowish spindle-shaped structure along the terminal groove. This arrangement was observed in 7 adults. The majority of nodes were in lateral position, but the so-called horseshoe arrangement was seen in 2 infants and 2 adults. The artery to the sinus artery was located centrally or eccentrically in the majority of cases, but the artery ramified through the nodal substance in 1 infant and 4 adults. We conclude that the node is not visible grossly in either the infant hearts or in those adult hearts without fatty infiltration. The whole cephalic part of the terminal groove should be carefully avoided to be sure of preventing the injury to the node during cardiac surgery.

Adult↗
PubMed1989

Tubal cyst following tubal sterilization: a delayed complication.

Clinical pictures and histopathological findings in 15 patients of tubal cyst following tubal sterilization were analyzed. The interval between tubal sterilization and occurrence of tubal cyst was 10 years (ranged from 4 to 21 years). Clinically 8 cases (53%) suffered from lower abdominal pain, 5 cases (33%) from hypermenorrhea coexistent with uterine myoma and 2 cases (13%) from irregular menstruation. Five out of 9 patients with ultrasound examination were suspected to have tubal cyst before operation. The size of tubal cyst ranged from 1.5 to 9.0 cm in diameter with mean 3.4 cm. Eleven were unilateral and 4 were bilateral. Histologically they showed flattened mucosal epithelial cells with absence of epithelial plica, compression atrophy of muscular layer, suture stitch or granuloma and intact fimbria with clear serous fluid. Thus, the differential diagnosis of adnexal cyst in patients with a past history of tubal sterilization should include tubal cyst.

Adult↗
PubMed1989

Reconstruction of right ventricular outflow tract by autologous pericardial tri-semilunar valve with sinus of Valsalva: report of a case with absent pulmonary valve.

The choice of a valved conduit or a valve in the right ventricular outflow tract remains a problem. We propose to reconstruct the pulmonary valve inside the patient's own pulmonary trunk by autologous pericardium in tri-semilunar fashion with concomitant formation of the sinus of Valsalva and commissure. This operation was carried out on a 7-year-old girl suffering from Fallot's tetralogy with an absent pulmonary valve. The ventricular septal defect was repaired and the pulmonary valve reconstructed as above. The postoperative cross-sectional echocardiogram, color Doppler echocardiogram and angiogram showed a pliable tri-semilunar valve across the pulmonary outflow tract without regurgitation. It is concluded that firstly, the sinus of Valsalva is indispensable for a stentless semilunar valve to be competent; secondly, reconstruction of the semilunar valve inside the pulmonary trunk by autologous pericardium is recommended for the absent pulmonary valve syndrome, but the long-term fate of this pericardial valve awaits further evaluation.

Child↗
PubMed1988

Extrarenal Wilms' tumor--a case report.

Extrarenal Wilms' tumor is extremely rare. To our knowledge, only 22 cases had been reported up to 1984. We treated a 5-year-old girl with an extrarenal Wilms' tumor arising in the right inguinal region. Total excision was performed. Abdominal sonogram, computed tomography (CT) scan, and intravenous pyelogram (IVP) showed normal kidneys, no other mass, and no evidence of metastasis. Postoperative chemotherapy was administered. The patient has been disease-free since first diagnosis 19 months ago.

Child↗
PubMed1988

Carcinoma of the gallbladder from an anomalous connection between the bile duct and the pancreatic duct.

Anomalous connection between the common bile duct and the pancreatic duct has recently been reported to be associated with cancerous changes of the biliary tract. A 52-year-old Chinese man had a fungating tumor in the gallbladder, and a long common channel between the bile duct and the pancreatic duct. The association of these two rare disease entities especially in a Chinese man may imply a close relationship between pancreatobiliary anomalous connection and the gallbladder cancer. It is thus prudent to monitor patients with such an anomalous connection closely by serial ultrasonic examination. More aggressively, prophylactic cholecystectomy and reconstruction of the biliary tract may be indicated.

Adenocarcinoma↗
PubMed1988

Pancreatic carcinoma associated with chronic calcifying pancreatitis in Taiwan: a case report and review of the literature.

A 62-year-old Chinese woman suffering from pancreatic carcinoma coexisting with chronic calcifying pancreatitis is reported. Ultrasonography and computed tomography disclosed multiple intraductal calcifications in the pancreatic head and body and a tumor at the tail. Laparotomy revealed cancerous peritonitis in addition to verifying the presence of calcifications at the head and body and a cancer at the tail. Histology confirmed adenocarcinoma. The incidence of pancreatic carcinoma in chronic calcifying pancreatitis varied from 0.8 to 25% in a thorough review of the literature. It is emphasized that patients with chronic calcifying pancreatitis should be closely followed for detection of possible coexisting pancreatic malignancies.

Adenocarcinoma↗
PubMed1988

Clinical implications of atrial isomerism.

Right atrial isomerism or left atrial isomerism is frequently diagnosed as situs ambiguous without further discrimination of the specific morbid anatomy. Thirty six cases of right atrial isomerism and seven cases of left atrial isomerism were collected from the records and pathological museum at the National Taiwan University Hospital. There was a necropsy report for 18 cases. In all patients one or more of the following conditions was met: (a) isomeric bronchial anatomy, (b) echocardiographic and angiocardiographic evidence of isomerism, and (c) surgical or necropsy evidence of abnormal atrial anatomy. An anomalous pulmonary venous connection was present in 55% of patients with right atrial isomerism; in left atrial isomerism one case (14%) had a partial anomalous pulmonary venous connection. Forty per cent of cases of anomalous pulmonary venous connection with right atrial isomerism had obstruction. Six (86%) of seven cases with left atrial isomerism had an ambiguous biventricular atrioventricular connection. In contrast, univentricular atrioventricular connection (26 of 36, 72%) was significantly more common in right atrial isomerism. A common atrioventricular valve was the most frequent mode of connection in both forms. Two discrete atrioventricular valves were significantly more common in left atrial isomerism. Atrioventricular valve regurgitation was detected in 14 cases. Double outlet right ventricle was the most common type of ventriculoarterial connection. The most commonly cited causes of death after either palliative or definitive operation were undetected anomalous pulmonary venous connection, pulmonary venous stricture, and uncorrected atrioventricular valve or aortic regurgitation complicated by abnormal coagulation. Although the prognosis is poor, successful operation depends on knowledge of the precise anatomical arrangement associated with atrial isomerism.

Abnormalities, Multiple↗
PubMed1988

Growth of the aortic anastomosis in pigs. Comparison of continuous absorbable suture with nonabsorbable suture.

Growth at the anastomotic site after continuous vascular anastomosis in the pediatric patient remains a problem. Primary end-to-end anastomosis of the infrarenal aorta was performed with absorbable Maxon suture or nonabsorbable Prolene suture in 20 piglets. Ten of the Maxon suture group and nine of the Prolene suture group survived; one pig died of infection. The animals were put to death 6 months after the operation. Each abdominal aorta was removed and a roentgenogram was obtained. The aorta was then burst-tested to 300 mm Hg, measured, and examined both grossly and histologically. All anastomoses were patent and no burst failures were observed in either group. However, Prolene sutures protruded into lumen and were partially embedded in the aortic wall in all animals in the Prolene suture group. Thrombus adhered to the intraluminal Prolene suture in six of nine animals. The growth of the anastomotic area was wider in the Maxon suture group (446.4% +/- 131.8% versus 317.6% +/- 121.5%, p less than 0.05). Stenosis was more common in the Prolene suture group (7/9) than in the Maxon suture group (1/10) (p less than 0.01), but the distal segment was widely patent in both groups. Dilatation at the anastomotic site was present in eight of 10 pigs in the Maxon suture group and in two of nine in the Prolene suture group. Histologic study showed that the area of tissue reaction was more prominent in the Prolene suture group. No sutures were observed in the Maxon suture group. We therefore recommend the use of absorbable Maxon sutures for anastomoses in which the suture line must be able to grow.

Absorption↗