Search PubMed⌕ Search

Biomedical subjects

S W Hall

Publications and source records attributed to S W Hall.

66 records · Page 4Linked to original sources
PubMed1978

Clinical phase I-II study of cis-dichloro-diammineplatinum(II) given by continuous lv infusion.

To determine the efficacy and toxicity of cis-dichlorodiammineplatinum(II) (DDP) by a continuous iv infusion (CIVI) schedule, 34 patients with a variety of solid tumors were studied. All patients were refractory to prior chemotherapy and received a loading dose of 5 mg/m2 of DDP iv followed by 20 mg/m2 by CIVI daily for 5 days. In 25 evaluable patients, there were four (16%) complete or partial responders, nine (25%) with stable disease, and 12 (48%) with tumor progression. One complete and one partial remission were seen in two patients with disseminated basal cell carcinoma, with partial responses also seen in cervical and head and neck squamous cancer. Patients experienced renal damage (21%) and audiotoxicity (10%). Nausea and vomiting was severe in only 6%. DDP by CIVI appears to have comparable toxicity to DDP administered by other schedules; however, the diminished gastrointestinal toxicity makes the drug better tolerated by patients for whom the inconvenience of a 5-day hospitalization is less than that caused by the nausea and vomiting of rapid infusion programs.

Cisplatin↗
PubMed1977

Hypereosinophilic syndrome with biventricular involvement.

In a 45-year-old man with hypereosinophilic syndrome, cardiac disease, mainly endocardial thickening and extensive mural thrombosis of both ventricles, was confirmed at autopsy. Early in the course of the disease, right ventricular endocardial biopsy had demonstrated the basic process. Restriction in filling and contraction of the right ventricle were demonstrated by functional studies. By echocardiographic study, progressive reduction in size of the right ventricular cavity and premature opening of the pulmonary valve were demonstrated, while this method was less adequate in identifying the process in the left ventricle.

Autopsy↗
PubMed1976

Treatment of uncomplicated gonorrhea with Polycillin-PRB.

Penicillin has remained the choice drug for the treatment of gonorrhea. Its cure rate has been relative, and because cure rates are not as good as one would wish, an additional increase in dosage has been advised. Despite an improved cure rate with increased dosages, we are rapidly approaching a dose requirement beyond that which can be administered practically on an outpatient basis. Therefore other antimicrobial agents have been evaluated for the treatment of gonorrhea. Ampicillin 2 gm (IM) with 1 gm probenecid was evaluated in 1969 with a 99% plus cure rate. It also has been found that 3.5 gm of ampicillin orally (7 capsules of 500 mg) and probenecid (2 tablets of 500 mg) is an effective treatment for gonorrhea. We undertook the present study to evaluate the efficacy of a new single oral combination treatment, Polycillin-PRB.

Adolescent↗
PubMedDate not supplied

Partial thromboplastin time: prediction of adverse events and poor prognosis by low abnormal values.

BACKGROUND: Clinical observations suggest an increased incidence of bleeding and thrombosis in association with a shortened partial thromboplastin time (PTT). OBJECTIVE: To determine whether abnormally fast PTTs are associated with an increased risk of death, thromboses, bleeding, and the overall occurrence of morbid events. METHODS: The medical records of 199 patients admitted in a 1-year period to a Veterans Affairs medical center were reviewed for PTTs and the events of death, thromboses, and severe bleeding. Group 0 (n = 49) consisted of patients with abnormally fast PTTs (<23 seconds). Group 1 (n = 50) consisted of patients with fast normal PTTs (23-25 seconds), and the control group, group 2 (n = 100), contained patients with PTTs from 28 to 31 seconds. The Cox proportional hazards regression was used to analyze the time-independent covariates of PTT groups, surgery, cancer, and other clinical variables as predictors of 3 outcome variables: bleeding, thrombosis, and death. RESULTS: Of the covariates examined, the PTT was found to be the most significant predictor of poor outcome. A statistically significant association was found between the PTT and time to death (P<.001), thrombotic events (P<.001), and bleeding (P<.006), and between the PTT and overall occurrence of morbid events (P<.001). Furthermore, survival curves showed that the greatest hazards of death, thrombosis, bleeding, and overall morbidity consistently occurred in group 0 compared with groups 1 and 2. CONCLUSIONS: Abnormally fast PTTs, particularly if confirmed on repeated testing, indicate a significant risk of subsequent death, thrombosis, bleeding, and overall morbidity. Careful examination of patients with low PTTs may reduce such associated morbidity and mortality.

Case-Control Studies↗