Negative trials.
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Biomedical subjects
Publications and source records attributed to S W Fletcher.
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OBJECTIVE: Manufactured silicone breast models were used to compare the accuracy of breast examination by 300 women and 62 internal medicine residents. DESIGN: The study design was cross-sectional. SETTING: The study took place in two teaching-hospital general medicine clinics. PATIENTS/PARTICIPANTS: Women were continuing care patients, ages 40 to 68, with no current breast complaint; 300 of 467 (66%) randomly selected women participated. Physicians were internal medicine residents with at least one-half day per week of ambulatory care practice; 62 of 64 (97%) participated. MEASUREMENTS AND MAIN RESULTS: Sensitivity equalled the percentage of 18 lumps correctly detected in examination of six silicone breast models. Specificity equalled the percentage of six models examined without a false-positive detection. Women's sensitivity was lower than physicians' (40% vs. 58%), but their specificity was higher (66% vs. 52%). For both women and physicians, sensitivity varied according to lump size, hardness, and depth, with women's sensitivity lower than physicians' for each characteristic. Examination duration was the technique most strongly and consistently related to accuracy. Physicians spent more time examining models than did women (2.5 vs. 2.1 minutes per model). For both groups duration related positively to sensitivity (r = 0.46, women; 0.55, physicians) and negatively to specificity (r = -0.35, women; -0.59, physicians). After adjusting for differences in technique, women's sensitivity remained lower than physicians', whereas specificity generally remained higher. The sensitivity of physicians with prior tactile experience with breast lumps was higher than that of physicians without such experience (60% vs. 51%, p = 0.01). Too few women (2%) had prior tactile experience to permit analysis. CONCLUSIONS: Women's and physicians' breast examination accuracies differ, but for the two groups accuracies vary similarly by lump characteristics and examination technique. Programs to improve breast examination should focus on specificity as well as sensitivity. Training that includes tactile experience may be important.
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Long-term outcomes in 123 morbidly obese patients who had undergone gastrogastrostomy were studied to determine weight losses 19 to 47 months after surgery. Follow-up data were available for 84% (103) of the patients. Overall, 58% of these (60 of 103) had maintained losses of greater than or equal to 30% excess weight. Using a best case/worst case analysis, between 49% and 65% of patients had achieved losses of greater than or equal to 30% excess weight. Six patients had gained weight. Eighty-seven per cent of the patients reported increased or stable energy levels; job status was stable or improved for 95%; and 20% had been rehospitalized. Use of antihypertensive medication and use of insulin had decreased. Over two thirds (69%) of the patients stated they would recommend gastrogastrostomy to a friend, and 54% were either very satisfied or satisfied with the operation. Energy level and degree of satisfaction were related to amount of weight lost. Gastrogastrostomy achieved long-term moderate weight losses in three fifths of morbidly obese patients, without causing serious adverse health outcomes.
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Health professionals' clinical breast examination accuracy and skills are not optimal. We conducted a randomized trial to evaluate changes in physicians' and nurses' lump detection accuracy and examination skills after a training program emphasizing development of tactile skills and using silicone breast models containing lumps of varying sizes, degrees of hardness, and depth of placement. Sensitivity, specificity, and examination technique were measured before and four months after training in 43 experimental group and 46 control group participants. Mean sensitivity increased from 57% to 63% in the experimental group but decreased from 57% to 56% in the control group (P less than or equal to .05). The experimental group's posttest sensitivity was better for each lump characteristic, with statistically significant improvement for the very small (0.3 cm) and medium hard lumps. Duration of examination independently predicted sensitivity. Specificity decreased from 56% to 41% in the experimental group while it increased from 56% to 68% in the control group (P less than or equal to .05). Physicians had significantly higher mean sensitivity than nurses overall, as well as for the larger (1.0 cm), very small (0.3 cm), and softer lumps, but significantly lower mean specificity (33% versus 57%, P = .03). The experimental group improved significantly in five of six technique components while the control group improved in only one. To determine the effect of training on specificity in the clinical setting, we examined medical records of women seen by a subset of experimental and control physicians during the six months following training. There were no significant differences in the proportion of abnormal breast examinations reported or the number of mammograms ordered by experimental and control physicians. Our results show health professionals can be taught successfully to improve their clinical breast examination accuracy and skills.
Prompting physicians increases performance of preventive procedures, but the long-term effects of prompting, and of different types of prompting (manual versus computer), on various procedures is unclear. Nor has the effect of the optional enrollment of patients by physicians into a prompting system been studied. We examined performance of eight preventive procedures in a university-based general medical practice during three successive periods over five years: no prompting, nurse-initiated prompting, and computerized prompting. Performance of seven prompted procedures for all patients (regardless of whether they had been enrolled) was significantly increased over the five-year period from 38% (no prompting) to 43% (nurse prompting) to 53% (computer prompting). Among the procedures, influenza vaccination (12% to 59%) and mammography (4% to 33%) showed the greatest increases in performance, while fecal occult blood testing and Pap smears showed no increase or slight declines. Enrollment of patients in the optional prompting system was strongly related to performance. Overall performance of procedures for the enrolled group increased to 68%, while that of the unenrolled group remained at 37%. However, after we adjusted for differences in the percentage of patients enrolled, overall performance for the nurse system (49%) differed little from that for the computer system (55%). Manual and computer prompts had similar effects, but the computer system prompted for more patients. Though prompting remained effective five years after initiation, performance did not increase for unenrolled patients or for some procedures. Understanding these patient- and procedure-specific barriers not addressed by prompting is necessary to increase further physician performance of preventive procedures.
The relationship of women's sociodemographic characteristics, knowledge, attitudes, and beliefs to breast self-examination (BSE) practice is not clear. We therefore studied these variables among older women at risk for developing breast cancer to determine which might be associated with the sensitivity, specificity, and frequency of BSE practice. We interviewed 300 women 40 to 68 years of age and measured BSE sensitivity and specificity using manufactured silicone breast models containing lumps. Of 54 variables and 10 scales examined univariately, six were associated with BSE sensitivity, one was negatively associated with specificity, and 10 were associated with frequency. No variable was associated with more than one component of BSE practice, and BSE frequency was not associated with BSE sensitivity or specificity. Using multivariate analysis, BSE sensitivity was best explained by type of employment, health interest, and perceived vulnerability to breast cancer, which accounted for approximately 16% of the variance. BSE frequency was best explained by intention to perform BSE, knowing how to perform BSE, using the correct method of BSE, self-confidence in the ability to perform BSE monthly, and self-confidence in the ability to find small lumps. These variables accounted for 27% of the variance. Sociodemographic characteristics, knowledge, attitudes, and beliefs poorly predicted how accurately women practiced BSE but somewhat better predicted how often women practiced BSE.
Computer prompting systems remind physicians to perform health promotion/disease prevention (HP/DP) procedures on their patients, but it is unclear how willingly physicians accept these systems. Because acceptance is critical to long-term system success, we assessed attitudes toward a computerized health maintenance program (HMP) prompting system. We surveyed 23 faculty and 52 residents in a general medicine teaching hospital group practice after the HMP had been in use for three years. Sixty-four physicians (85 percent) responded. Almost all (91 percent) agreed that all ongoing-care patients should receive periodic screening--a significant (p less than .001) increase compared to 1979, when prior to the HMP 56 percent agreed. On average, the physicians believed that 87 percent of their ongoing-care patients over 50 years of age should be enrolled in the HMP. About half (55 percent) felt that losing the HMP would limit their ability to care for their patients, and almost all (97 percent) said they would include a prompting system in any future private practice, with most (87 percent) preferring a computer-based system. A majority (65 percent) said that they liked being reminded. Prompting systems improve physician performance of HP/DP procedures. The HMP received a high level of acceptance and was associated with improved attitudes toward HP/PD activities, suggesting that computerized prompting systems should be more widespread.
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Our objective was to determine whether an educational intervention and prompting intervention for physicians improved dietary counseling of patients with high blood cholesterol and resulted in beneficial changes in patients' diets and cholesterol levels. We instituted a factorial design, multicenter, randomized, placebo-controlled trial to test two interventions. We tested the trial at continuity care clinics of internal medicine residents at seven community and university medical centers in the northern and eastern United States. Our participants were 130 internal medicine residents and 254 adult outpatients with blood cholesterol levels of 240-300 mg/dL. Interventions included an educational program for resident physicians designed to improve their skills and confidence in dietary counseling (two one-hour sessions with specially prepared printed materials for use in counseling) and a prompting intervention, which was a fingerstick blood cholesterol determination prior to the patient's clinic visit. Resident physicians' knowledge, attitudes, and self-reported behaviors were assessed prior to the intervention and 10 months later using chart audits and questionnaires. Residents' behaviors were also assessed by exit interviews with patients. Patients' knowledge, attitudes, behaviors, and fingerstick blood cholesterol levels were measured at baseline and 10 months later. The educational program increased the percentage of physicians who were confident in providing effective dietary counseling (baseline of 26% to 67%-78%; P < .01). The prompting intervention approximately doubled the frequency of physician counseling (P = .0005) and increased the likelihood that patients would try to change their diets. When both interventions were combined, most outcomes were better, although not statistically significant. Cholesterol levels, however, decreased only marginally and were no different among groups at 10-month follow-up. Despite success in changing physicians' attitudes and behaviors and increasing patients' willingness to change their diets, there was no significant change in patients' cholesterol levels. Medical Subject Headings (MeSH): randomized controlled trial; cholesterol; patient education; behavior therapy; education, medical; diet.
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