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Biomedical subjects

S W Berg

Publications and source records attributed to S W Berg.

26 records · Page 2Linked to original sources
PubMedDate not supplied

One gram of cefoxitin cures uncomplicated gonococcal urethritis caused by penicillinase-producing Neisseria gonorrhoeae (PPNG).

Therapy of disease caused by penicillinase-producing Neisseria gonorrhoeae with lower-than-standard doses of cefoxitin was evaluated. A pilot study showed that doses of greater than or equal to 1 g were adequate, whereas 500-mg doses consistently failed. After the pilot study, 89 men with gonorrhea were treated with 1 g of cefoxitin given intramuscularly plus 1 g of probenecid given orally. Of the 89 men, 86 were cured. Sixty per cent were infected with penicillin-resistant strains of N. gonorrhoeae. The three men who were culture-positive on follow-up had been sexually reexposed, whereas none of those with negative cultures had had reexposure. These clinical results indicate that a treatment regimen of 1 g of parenteral cefoxitin plus 1 g of oral probenecid appears to be as effective as the standard 2-g dose. Regimens using doses lower than 1 g are ineffective.

Adolescent↗
PubMedDate not supplied

Ceftizoxime (FK-749) is effective therapy for urethritis caused by penicillinase-producing Neisseria gonorrhoeae.

Fifty-five men with culture-proved gonococcal urethritis caused by either penicillin-sensitive or penicillinase-producing Neisseria gonorrhoeae were treated with 1 g of ceftizoxime given intramuscularly. All patients were cured, including 26 (47%) with penicillinase-producing strains. Patients experienced no local or systemic side effects and tolerated the injection of ceftizoxime well. These results show that ceftizoxime is an effective alternative to either spectinomycin or cefoxitin in treatment of uncomplicated gonococcal urethritis caused by penicillin-resistant bacteria.

Cefotaxime↗
PubMedDate not supplied

A comparison of penicillin G plus a beta-lactamase inhibitor (sulbactam) with spectinomycin for treatment of urethritis caused by penicillinase-producing Neisseria gonorrhoeae.

When combined with penicillin, sulbactam, a beta-lactamase inhibitor with weak intrinsic antibacterial activity, produces a marked synergistic effect in vitro against penicillinase-producing Neisseria gonorrhoeae. We compared a regimen of aqueous procaine penicillin G, sulbactam, and probenecid with spectinomycin for the treatment of uncomplicated gonococcal urethritis. Of 101 patients receiving the penicillin-sulbactam regimen, 97 (97%) were cured of their infection, as were 87 (95%) of 92 patients who received spectinomycin. Fifty per cent of patients were infected with penicillinase-producing N. gonorrhoeae; 43 (94%) of 46 treated with the penicillin-sulbactam regimen were cured as compared with 47 (92%) of 51 treated with spectinomycin. Neither regimen was associated with serious adverse effects. The results show that aqueous procaine penicillin G given with sulbactam and probenecid is an effective alternative for single-session therapy of urethritis caused by penicillinase-producing N. gonorrhoeae.

Adult↗
PubMedDate not supplied

Epidemiology of reported syphilis among U.S. Navy and Marine Corps personnel, 1985-1987.

The authors analyzed four hundred fifty-six cases of syphilis reported via a passive disease surveillance system in the Navy and Marine Corps during 1985-1987. The annual incidence of all reported cases significantly increased during this time from approximately 16 out of 100,000 in 1985 to 23 out of 100,000 in 1987. Much of this increase is attributed to concurrent increased rates of primary syphilis and late latent syphilis. Incidence rates for all stages of syphilis combined increased significantly among men and blacks during these years. Cumulatively, most reported patients were male (422, 96.1%), aged 20-24 years (204, 55.1%), E-3 (junior) enlisted pay grade (101, 30.1%), and black (217, 53.8%). Sexual exposures were reported most frequently from the eastern U.S. coast and from western Pacific countries.

Adolescent↗
PubMedDate not supplied

Aminoglycoside dosing.

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Aminoglycosides↗