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S Vynckier

Publications and source records attributed to S Vynckier.

51 records · Page 3Linked to original sources
PubMed1989

Results of 10 y of radiation protection dosimetry at the neutrontherapy facility in Louvain-la-Neuve.

After 10 y of routine operation, radiation hazards to the neutron therapy staff at Louvain-la-Neuve were evaluated. These hazards to the staff in neutron therapy are a matter of concern, not only because of the dose levels due to induced activation after treatment but also because of the difficulty of evaluating adequately the dose equivalent rates (including the quality factor, QF) during the irradiation. Build-up of radioactivity near the collimator and in the therapy room is reported. In the beam axis, dose rates due to activation can amount up to 5 mGy h-1. However, these rates are efficiently reduced to 0.3 mGy h-1 by automatically withdrawing the target after irradiation. Other problems of radioactive contamination (for instance, the choice of the Fe composition of the collimator) are discussed. Dose equivalent rates were determined during treatment at different positions inside and outside the treatment room. At these locations, neutrons of widely varying energies are present, accompanied by a significant proportion of gamma rays. The measurements of neutron-dose equivalent rates were performed with three commercial neutron detectors: a BF3 and a He3 remcounter (Nuclear Enterprises and Nardeux) and the Dineutron multisphere remcounter (Nardeux). The Dineutron also allowed the evaluation of QF. The results of these detectors were compared with the results of the integration of microdosimetry spectra obtained in free air with a TE proportional counter (Far West Technology). For the p(65) + Be neutrons, the dose equivalent rate was equal to 0.4 Sv h-1 in the treatment room (at 2.5 m from the collimator) and was reduced to 2-3 microSv h-1 at the room entrance. The gamma component increased from 55% to 95% at the same positions, respectively. Ratios of the responses of all detectors and QF values are compared and discussed at the different positions. The whole-body dose equivalents to the neutron therapy staff over the 10 y considered are presented; although they are higher than for conventional radiotherapy, they remain far below the ICRP recommended dose limits.

Fast Neutrons↗
PubMed1989

Kinetics of sublethal damage recovery in mouse lip mucosa comparing low and high-LET radiation.

The effects of d(50) + Be neutrons on the lip mucosa in mice were investigated as a model of early effects. The biological endpoint eas the incidence of desquamation in the lower lip after selective irradiation of the snout of the animals. ED 50 (dose leading to desquamation in 50% of the animals) were calculated by probit analysis. Fractionated (two, four and ten fractions) and protracted (43.5, 11.5 and 0.88 Gy.h-1) irradiations have been carried out. Results were analysed using the mathematical method of Dale. An alpha/beta of 39.6 Gy and a t 1/2 of recovery of sublethal damage of 47 min have been derived. These results have been compared to data previously obtained with cobalt-60 gamma rays. Using the same mathematical approach, and comparing similar fractionated and protracted experiments, an alpha/beta of 7.4 Gy and a t 1/2 of recovery of 47 min have been calculated. There was no significant difference in the repair kinetics after irradiations with gamma rays or d(50) + Be neutrons.

Animals↗
PubMed1989

Radiobiological intercomparisons of fast neutron beams used in therapy.

A research program was performed at Louvain-la-Neuve to systematically determine the RBE of fast neutrons for the growth inhibition in Vicia faba bean roots and for the regeneration of the intestinal crypts in mice. The following neutron beams were compared p(75) + Be, p(65) + Be, p(45) + Be, p(34) + Be, d(20) + Be, and d(50) + Be. The RBE-variation as a function of neutron energy is larger for the Vicia faba system than for the regeneration of the intestinal crypt cells. This can be related to the inherent differency of the biological systems, but also to the different dose ranges involved (0.33 to 0.56 Gy and 7.66 to 8.56 Gy, respectively). In the high energy range explored, defined by the reactions p(75) + Be to p(34) + Be RBE varies only between 0.92 and 1.28 for Vicia faba and 0.96 and 1.12 for crypt cells normalized to the p(65) + Be beam. By contrast the RBE at lower energy beams (d(20) + Be and d(14.5) + Be) reaches values between 1.5 and 1.6 Finally fractionation has shown to be likely more important at the high energy beams.

Animals↗
PubMed1989

Radiobiological intercomparison of clinical neutron beams for growth inhibition in Vicia faba bean roots.

Relative biological effectiveness (RBE) and oxygen enhancement ratio (OER) values of different neutron beams produced at the variable energy cyclotron "Cyclone" of Louvain-la-Neuve (Belgium) were determined. The neutrons were obtained by bombarding a beryllium target with 34-, 45-, 65-, or 75-MeV protons or with 50-MeV deuterons. The biological system was growth inhibition in Vicia faba bean roots. Taking the p(65) + Be neutron beam as a reference, RBE values were found equal to 1.36 +/- 0.2, 1.20 +/- 0.1, 1.00 (ref), 0.98 +/- 0.1, and 1.18 +/- 0.1, respectively; the doses corresponding to 50% growth inhibition were 0.39, 0.44, 0.53, 0.54, and 0.45 Gy. For the same beams, OER values were found equal to 1.55 +/- 0.1, 1.38 +/- 0.1, 1.29 +/- 0.1, 1.41 +/- 0.1, and 1.60 +/- 0.2, respectively.

Growth↗
PubMed1988

The Clatterbridge high-energy neutron facility: dosimetry intercomparisons.

Dosimetry intercomparisons have been performed between the Clatterbridge high-energy neutron facility and the following institutions, all employing beams with similar neutron energies: Université Catholique de Louvain, Belgium; University of Washington, Seattle, USA; MD Anderson Hospital, Houston, USA; and Fermi National Accelerator Laboratory, Batavia, USA. The purpose of the intercomparison was to provide a basis for the exchange of dose-response data and to facilitate the involvement of Clatterbridge in collaborative clinical trials. Tissue-equivalent ionization chambers were used by the participants in each intercomparison to compare measurements of total (neutron plus gamma) absorbed dose in the host institution's neutron beam, following calibration of the chambers in a reference photon beam. The effects of differences in exposure standards, chamber responses in the neutron beams and protocol-dependent dosimetry factors were all investigated. It was concluded that the overall difference in the measurement of absorbed dose relative to that determined by the Clatterbridge group was less than 2%.

Calibration↗
PubMed1987

[Relative biological effectiveness (RBE) of neutrons produced by 50 MeV deuterons and by 34, 45, 65 and 75 MeV protons].

RBE of p(34) + Be, p(45) + Be, p(65), + Be, p(75) + Be and d(50) + Be neutron beams produced at the cyclotron "Cyclone" of Louvain-la-Neuve were measured. The biological criterion was the regeneration of the crypts of the intestinal mucosa (50 regenerated crypts per circumference) after abdominal irradiation in mice. Taking the p(65) + Be neutrons as reference, RBE values were found equal to 1.12, 1.07, 1.00 (Ref.), 0.96 and 1.02 respectively. These results are consistent with those published for cell lethality in vitro. However, the RBE variation is smaller than this previously obtained in the laboratory for growth inhibition in Vicia faba.

Activation Analysis↗
PubMed1985

Scaling relative neutron depth-dose distributions from one phantom material to another: a comparison of experimental and theoretical results.

To correct percentage depth-dose data from one phantom material to another, experimental and theoretical scaling factors (SF) are compared for different neutron beam qualities. Differences of up to 10% were observed for different phantom materials relative to water. The ratio SF/rho was plotted as a function of H concentration by mass where rho is the mass density of the phantom material. A nearly linear relationship resulted at all energies for the theoretical scaling factors, while, for the experimental points, important deviations appeared at high energies for materials with relatively low H and high C concentrations. It can be shown that a single linear relationship for all compounds composed of H, C and O can only be valid if the ratio of total cross sections of carbon to oxygen is equal to 3/4. Experimental scaling factors will be more accurate than calculated values because of the uncertainty in the average total cross sections. If these factors for tissue equivalent (TE) liquid relative to water are converted to those of ICRU muscle by correcting to a mass density of 1.04 g cm-3, then the scaling factors are, within experimental uncertainty, equal to one.

Fast Neutrons↗
PubMed1985

[Microcinematographic study of the lengthening of the cell cycle after x-ray and fast neutron irradiation].

The median cycle duration of unirradiated EMT6 cells is equal to 9.68 +/- 0.20 h. It reaches 10.77 +/- 0.42 h, 12.95 +/- 0.62 h, 14.95 +/- 1.10 h, 16.15 +/- 1.87 h and 20.25 +/- 2.25 h after 250 kV X-rays doses of 1 Gy, 2 Gy, 4 Gy, 6 Gy and 8 Gy respectively and 11.23 +/- 1.03 h, 13.40 +/- 0.53 h and 15.13 +/- 1.15 h after p(65) + Be neutron doses of 0.75 Gy, 1.5 Gy and 2.5 Gy respectively. The corresponding mitotic delay (Tc irradiated - Tc controls) may be evaluated equal to congruent to 1.15 h per Gy for X-rays and to congruent to 2.30 h per Gy for neutrons.

Animals↗
PubMed1983

Improvement of a p(65)+Be neutron beam for therapy at Cyclone, Louvain-la-Neuve.

The variable energy cyclotron of the Catholic University of Louvain is used to produce intense neutron beams for neutron therapy purposes. As a first step, neutrons were produced by bombarding a Be target with 50 MeV deuterons; at present they are produced by 65 MeV protons. This paper describes the improvements to the target system. A new (17 mm) Be target together with the old (10 mm) Be target are inserted in a movable support which allows the production of neutrons either by 65 MeV protons or by 50 MeV deuterons. Both targets can be removed for proton beam therapy. The dosimetric characteristics of the p(65)+Be and d(50)+Be neutron beams are compared: dose rate, gamma-contribution, depth dose and room activation.

Fast Neutrons↗
PubMed1982

Dosimetry of beta sources in radiotherapy I. The beta point source dose function.

The dose distribution around a point source of a beta-emitting radionuclide in an homogeneous medium is considered. The beta point dose function proposed by Loevinger in 1956 is discussed with respect to the most recent experimental and theoretical available data of Cross and Berger. The Loevinger function provides a reasonable evaluation of the dose distribution at distances of clinical interest. A re-evaluation of the parameters can still improve the situation. A slightly modified formula provides a description of the dose distribution around 32P and 90Y point sources, which is in close agreement, at all relevant distances, with the data of Cross and Berger. This formula can be integrated to provide the dose distribution around beta sources of other shapes.

Electrons↗
PubMed1982

Comparison of neutron therapy beams produced by 50 MeV deuterons and 65 MeV protons on beryllium.

Neutron beams produced by bombarding a 10 cm thick beryllium target with 50 MeV deuterons have been used at Louvain-la-Neuve since nearly 4 years for routine therapeutic applications. At the end of 1981 they were replaced by neutron beams produced by 65 MeV protons on beryllium, mainly in order to improve the beam penetration in tissues. However, produced of neutrons from the p leads to Be reaction implies some disadvantages, mainly a lower dose rate and a higher activation level. In order to solve the problem a new target configuration was designed, consisting of a remote handled system which permits the use of 2 different target assemblies. The irradiated target is automatically removed immediately after the irradiation which greatly protects against exposure to the staff. The dosimetric characteristics of the d(50)-Be and p(65)-Be neutrons beams are compared.

Beryllium↗