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Biomedical subjects

S Vincent

Publications and source records attributed to S Vincent.

At least 109 records · Page 6Linked to original sources
PubMed1981

Inhibition of Neisseria gonorrhoeae by sodium polyanetholesulfonate.

Sodium polyanetholesulfonate (SPS), in concentrations commonly used in blood culture media, inhibited the growth of a significant number of isolates of Neisseria gonorrhoeae in an agar dilution system. This SPS toxicity, shown to be bactericidal when examined in broth culture, could be reversed by hemoglobin and gelatin. Gelatin in 1% concentration allowed optimal growth of SPS-sensitive isolates in the presence of 0.025% SPS. Of 50 clinical isolates of N. gonorrheae tested under simulated blood cultures conditions with SPS, 16 isolates failed to grow on subculture at days 1, 3, and 10 after inoculation. Recovery was delayed with eight isolates as compared to controls. Early subcultures at 4, 8, and 12 h failed to recover SPS-sensitive isolates, whereas 1% gelatin, added even as late as 8 h after inoculation, reversed the SPS toxicity. The data reported suggest that SPS at concentrations routinely used in blood cultures can delay or prevent isolation of N. gonorrhoeae, but 1% gelatin can eliminate this adverse effect.

Benzenesulfonates↗
PubMed1981

Visual and auditory evoked responses in patients with Parkinson's disease.

Visual evoked responses were obtained in 47 Parkinsonian patients and 26 age-matched controls. The stimulation to binocular and uniocular latency of the major positive peak was longer in the Parkinsonian patients and its amplitude was smaller than in the control subjects. There was a large interocular difference suggesting that at least part of the delay occurs at prechiasmatic level. The latency and amplitude varied markedly following ingestion of levodopa as Sinemet. Auditory evoked potentials were obtained in 16 Parkinsonian patients and 11 age-matched controls. The latency of the NV wave was prolonged in the former although the amplitude was the same, suggesting that the abnormality may be a widespread one.

Aged↗