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Biomedical subjects

S Vesterhauge

Publications and source records attributed to S Vesterhauge.

At least 19 recordsLinked to original sources
PubMed1994

[Bone-anchored auricular prosthesis].

During the period February 1989-September 1991, 15 patients with absent or defective pinna were treated with a bone-anchored auricular prosthesis at the ENT-department, Rigshospitalet, Copenhagen. These patients were followed up from the hospital records and by means of a questionnaire. Altogether 40 titanium implants have been inserted, of which one implant was found not to be integrated at the time of the second-stage surgery. Five patients underwent additional surgery, one patient because of non-integration of a screw, and four patients on account of soft-tissue reactions. From the questionnaire replies it appears that all patients found the cosmetic result and the technique concerning mounting of the prosthesis very satisfactory. Nearly half the patients found that the care of the skin around the abutments caused considerable problems. Three patients had experienced unintended losses of the prosthesis. In conclusion, treatment with a bone anchored auricular prosthesis has considerable advantages compared to treatment with a prosthesis attached by adhesive. Furthermore the use of a bone-anchored prosthesis should be considered a viable alternative to surgical reconstruction because of the outstanding aesthetic result and because the surgical procedure puts less strain on the patient. The disadvantage of the method is the lifelong daily care of the skin and the dependence on the health services.

Adult↗
PubMed1988

Clinical diagnosis of vestibular disorders. A system approach to dizziness.

During recent decades, vestibular research has emphasized that it is important to consider vestibular reflexes a part of the integrated balance system function. Vestibular diagnosis must be based on a system approach to vestibular dysfunction. The development of new balance system examination methods is based on computerization of the analysis of transfer functions. Using these methods, system dysfunction is more easily understood and a new universe of vestibular diagnosis might develop in the years to come.

Animals↗
PubMed1987

Heart rate responses to moderate linear body accelerations: clinical implications in aeromedical evacuation.

Linear accelerations during take-off and landing were measured in both civilian and military aircraft usually involved in aeromedical evacuations in Denmark. Accelerations of similar durations and magnitudes were induced in six healthy subjects transported in an ambulance in different supine positions. Heart rate responses recorded depended significantly on the position of the subject. It was concluded that seriously ill patients must be positioned transversely to the axis of acceleration during aeromedical evacuation.

Acceleration↗
PubMed1987

A new and simple calibration of the electro-ocular signals for vestibulo-ocular measurements.

Reliable calculation of the gain of the vestibulo-ocular reflex depends on a reliable way of calibrating the eye movements. During the new calibration manoeuvre, the subject fixes the eyes at a point about 1 m away and moves the head either in pitch or yaw approximately +/- 30 degrees. The head movements are recorded by means of an angular rate sensor. The eye movements are recorded with standard surface electrodes. By integrating the angular rate signal the precise head position angle is calculated. The fixating eyes will compensate for this angle and, thus, the signal level of the eye movements is defined. A systematic error is introduced in this procedure. Because the distance to the fixating point is finite, the eyes must deviate more than the head movement. The extra angle is dependent on the distance to the target. In yaw, the angle is independent of the direction of the head movement. In pitch, the angle is both dependent on the distance to the target and on the direction of the head movement. Correction for the error must, in most cases, be performed directly on the eye recordings before calculating the VOR gain.

Calibration↗
PubMed1986

Acquired intolerance to organic solvents and results of vestibular testing.

Among 160 consecutive patients referred to the Clinic of Occupational Medicine, Rigshospitalet, for symptoms connected with exposure to organic solvents, 20 exhibited symptoms of acquired intolerance to minor amounts of organic solvents. Later, an additional 30 consecutive patients with symptoms of acquired intolerance were included, yielding a total of 43 men and 7 women. The characteristics of the clinical syndrome described are complaints of dizziness, nausea, and weakness after exposure to minimal solvent vapor concentrations. After having tolerated long-term occupational exposure to moderate or high air concentrations of various organic solvents, the patients became intolerant within a short period of time. Since dizziness was a frequent complaint, we tried to obtain a measure of the patients' complaints using vestibular tests. As a diagnostic test the combined vestibular tests had a sensitivity of 0.55 and a specificity of 0.87. No differences between patients with and without intolerance could be detected by the vestibular tests used. We conclude that acquired intolerance to organic solvents is a new but characteristic and easily recognizable syndrome, often with severe consequences for the patient's working ability.

Adult↗
PubMed1984

Caloric testing with small temperature gradients. Caloric zero.

Caloric nystagmus was investigated in 50 normal subjects with stimulation of the temperatures 30, 33, 35, 39, 41, and 44 degrees C. Mean values of the duration and the eye speed of the slow phase of adjacent temperatures were significantly different. No difference could be demonstrated between the equidistant temperatures 30/44 and 35/41 degrees C, but the response was significantly stronger with 35 than with 39 degrees C. This indicates that the caloric zero, i.e., the theoretical neutral temperature, is higher than 37 degrees C. The caloric zero was determined by extrapolation of the regression lines of the mean values for the six temperatures investigated. Determination by means of maximum eye speed of the slow phase values showed to be more accurate than with the duration, probably due to smaller interindividual variations of the responses.

Adolescent↗
PubMed1983

Spontaneous nystagmus in central nervous disease.

Over a 10 yr period, 23,899 patients from the neuromedical and neurosurgical departments were examined for spontaneous nystagmus. A central spontaneous nystagmus was found in 281 patients (1.2%).

Central Nervous System Diseases↗
PubMed1982

Treatment of pulmonary Pseudomonas aeruginosa infection in cystic fibrosis with cefsulodin.

20 patients with cystic fibrosis and chronic pulmonary Pseudomonas aeruginosa infection underwent a total of 23 courses of treatment with a new cephalosporin, cefsulodin. The patients were given 100-150 mg/kg/day in 3 divided doses for 14 days, alone or in combination with tobramycin. Maximum serum levels were around 150 microgram/ml and 6-h levels above 5 micrograms/ml. 90% of the infecting strains were sensitive to 5 micrograms/ml in vitro. Apart from discomfort in direct relation to intravenous bolus injection the drug was well tolerated. Clinical improvement was pronounced, and in 5 cases. P. aeruginosa disappeared from bronchial secretions. Patients allergic to carbenicillin tolerated cefsulodin without signs of allergy. Cefsulodin thus appears to be an effective alternative to carbenicillin in the treatment of severe P. aeruginosa infections.

Adolescent↗
PubMed1981

Computer analysis of electronystagmographic data.

Manual calculation of the parameters of nystagmus is imprecise and time consuming. Therefore, a computer program for analysis of nystagmus has been built up in our laboratory. The program is based on automatic extraction of the minimum and maximum values nystagmus. These values are stored for calculations of duration, amplitude and velocity of the fast and slow phase. The distinction between the slow and fast phase is based on the duration of the phases. The program is thus able to accept nystagmus in different directions.

Computers↗
PubMed1980

Netilmicin in urinary tract infections.

30 urological patients with normal renal function were treated with netilmicin because of urinary tract infections, mostly recurrent and due to predisposing factors. the drug was given in doses of 4 mg/kg/day for 4-9 days. All but 5 patients had resolution of their signs and symptoms, and the bacteria were eliminated in 23 patients, with recurrence in 8 and reinfection in 3. The bacteria persisted in 1 patient and the results were indeterminate in 6 patients. No signs of hematopoietic, renal and hepatic toxicity occurred, and vestibular and auditory functions were undisturbed. Regular assays of serum drug concentrations revealed no signs of accumulation. Netilmicin given in doses of 4 mg/kg/day is an efficient antibiotic with low toxicity in the treatment of urinary tract infections.

Adolescent↗
PubMed1980

Netilmicin treatment followed by monitoring of vestibular and auditory function using highly sensitive methods.

Auditory and vestibular function was monitored in 30 patients treated with netilmicin for urinary tract infection. During and after the treatment, no signs or symptoms appeared that could be ascribed to an ototoxic effect of the drug. Routine acoustico-vestibular tests as well as advanced, objective acoustic tests revealed no signs of impairment of the labyrinth function. Results of highly sensitive vestibular tests in 15 patients including computerized analysis of the nystagmus responses to caloric tests were compared with results obtained from a sample of normal individuals. Some of the results varied significantly more in the netilmicin group than in the reference group. The most characteristic variation was a decreased reaction to hot water stimulation.

Adolescent↗
PubMed1979

Oral decongestant in acute otitis media. Results of a double-blind trial.

In order to investigate the influence of an orally administered decongestant, norephedrine, upon the clinical course of acute otitis media and tubal function, a double-blind trial was performed in Copenhagen in December, 1976-February, 1977, in which 93 patients, aged 6 months to 10 years, with 135 ears with acute otitis media, were treated either with norephedrine or placebo in a randomized order. Most other treatment was avoided except for pain-relieving baby aspirins. The effect of norephedrine seemed to be no other than that of placebo. Because of this inefficacy of norephedrine the authors have, therefore, a material of patients with acute otitis media where the main treatment was pain-relieving aspirin. The use and abuse of antibiotics in the treatment of this disease are discussed, and the authors stress the necessity of performing controlled studies of the efficacy of antibiotics in acute otitis media, since such studies do not exist.

Acute Disease↗