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Biomedical subjects

S Verma

Publications and source records attributed to S Verma.

At least 271 records · Page 15Linked to original sources
PubMed1983

A study of sulindac versus ibuprofen in elderly patients with osteoarthritis.

A study was carried out in 30 elderly patients, aged between 65 and 89 years, with osteoarthritis of the hip and/or knee joints to assess the efficacy and tolerance of sulindac compared with ibuprofen. Patients were allocated at random to receive either 200 mg sulindac twice daily or 400 mg ibuprofen 3-times daily for 12 weeks. The results showed that whilst both drugs produced improvement in the patient symptoms assessed, the only improvements reaching a statistically significant level were those for weight-bearing pain, pain on passive movement of the left lower limb joints and disease activity in the sulindac group. Both drugs were well tolerated and few side-effects were reported. However, 1 patient in the sulindac group had haematemesis and melaena (Week 1) and 1 in the ibuprofen group developed a rash (Week 9) and had to be withdrawn.

Aged↗
PubMed1979

Dependence on chlormethiazole and effects of its withdrawal.

Five cases of physical dependence on chlormethiazole are reported. Because sudden withdrawal may precipitate an acute "organic psychosis", chlormethiazole should only be used in hospitals and, even then, only for a maximum of 9 days.

Acute Disease↗
PubMed1979

IgE antibodies to peptic and peptic-tryptic digests of betalactoglobulin: significance in food hypersensitivity.

The sera of 20 atopic patients, 10 with hypersensitivity symptoms upon ingestion of milk and 10 without such symptoms, were tested by a radioimmunoassay for the detection of IgE antibodies to whole bovine milk, betalactoglobulin (BL), enzymatic digests of BL and fractions thereof. While only 4/10 patients had IgE antibodies to undigested BL all 10 patients had IgE antibodies to BL digests. All controls gave negative results. These findings suggest that enzymatic digestion of BL may yield antigenic fractions which elicit IgE antibodies and that these antibodies would be missed if the undigested food protein were to be used solely in testing.

Adolescent↗
PubMed1977

Amitriptyline and weight gain: a biochemical and endocrinological study.

A study was carried out in 6 healthy volunteers to test the hypothesis that weight gain associated with amitriptyline treatment may be due to hypoglycaemia caused by increased circulating blood insulin. Subjects were treated with 50 mg amitriptyline b.d. for 28 days. Estimations made of serum levels of amitriptyline and its metabolite nortriptyline showed a steady state by the 10th day. No significant weight-gain was observed in any of the volunteers, although 2 reported an increase in appetite. There were no significant differences in any of the glucose tolerance curves, fasting or peak insulin levels or in the glucose/insulin curves for Days 0, 14 and 28.

Amitriptyline↗
PubMed1975

Cephalexin-related nephropathy.

Hematuria and eosinophilia developed in two patients being treated for bacterial endocarditis with 20 or 24 gm/day of cephalexin given orally together with probenecid (Benemid). One patient had a concurrent transient increase in serum creatinine; both patients had a history of penicillin allergy and had previously received cephalexin intravenously. All abnormalities promptly remitted following discontinuation of therapy.

Administration, Oral↗
PubMedDate not supplied

Neural tubal defects in an east Delhi hospital.

A high incidence of congenital neural tube defects was suspected among the babies born in East Delhi. The hospital data of 30 months was reviewed to find out the incidence and to evaluate the prenatal diagnosis in these disorders. An incidence of 7/1000 births was found to be correct in all cases of anencephaly and hydrocephalus. However, spina bifida and encephalocele were missed in 25% of cases. All patients were diagnosed late during pregnancy mainly because of late booking. Early booking and a high index of suspicion are desirable for early prenatal diagnosis.

Abnormalities, Multiple↗