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Biomedical subjects

S Varma

Publications and source records attributed to S Varma.

At least 181 records · Page 10Linked to original sources
PubMed1986

Double-blind comparison of intravenous doses of dezocine, butorphanol, and placebo for relief of postoperative pain.

The safety and efficacy of intravenous doses of dezocine (5 or 10 mg), butorphanol (1 mg), and placebo were compared in a double-blind study in 160 patients with moderate to severe postoperative pain. Analgesic efficacy was assessed for 6 hours after each dose. Mean pain relief scores were consistently higher, indicating greater pain relief, for the three active treatment groups than for the placebo group. The 10-mg dezocine dose was the most effective treatment, and 5 mg of dezocine was comparable to 1 mg of butorphanol. In the 2 hours after the first dose, 32% of the 10-mg dezocine group, 53% of the 5-mg dezocine group, 65% of the butorphanol group, and 88% of the placebo group withdrew from the study because of unsatisfactory pain relief. The differences in these percentages were statistically significant (P less than 0.05) between each active therapy group and the placebo group, and between the 10-mg dezocine group and the butorphanol group. Changes in degree of sedation were similar in the three active therapy groups. Adverse reactions were rare, mild, and equally distributed among the four treatment groups. We conclude that 10 mg of dezocine is superior to 1 mg of butorphanol, and that 5 mg of dezocine is as effective as 1 mg of butorphanol for the relief of moderate to severe postoperative pain.

Adolescent↗
PubMed1985

Cryosurgery of bovine squamous cell carcinoma of the vulva.

Sixty-two cattle with vulval carcinoma of various sizes were treated by cryosurgery using double freeze-thaw cycles. A cure rate of 88.7 per cent was achieved. It was confirmed that the smaller the lesions the better the response and that in larger lesions failure occurred because of the difficulty in freezing the mass of neoplastic tissue rapidly to the lethal temperature of -25 degrees C using the cryosurgical unit available. It was concluded that, if instituted early in the clinical course of the disease, cryotherapy of bovine vulval carcinoma is superior to surgical excision but the cost of the equipment may be a limiting factor in its application in the field.

Animals↗
PubMed1983

A clinical study of post polio infantile paralysis.

This study reports on 3,000 cases of poliomyelitis seen at the Rehabilitation and Artificial Limb Centre at Lucknow between January 1976 and December 1980. Factors such as age and sex incidence, extremity involvement, incidence of deformities at hip, knee and ankle, lower limb discrepancy, treatment and orthoses prescribed are discussed.

Age Factors↗
PubMed1982

Characterization of a glucocorticoid receptor and the direct effect of dexamethasone on herpes simplex virus infection of rabbit corneal cells in culture.

Homogenates prepared from a previously established cell line derived from rabbit cornea contain a macromolecule with many properties of a glucocorticoid receptor, namely high affinity (KD = 6 x 10(-9)M) and saturable capacity (135 femtomoles/mg protein) for dexamethasone, extreme heat lability, and a pattern of competition similar to that found in other glucocorticoid target cells. Intact cells specifically bind dexamethasone with an affinity similar to that found in homogenates, and the amount of steroid bound at saturation is approximately 60,000 molecules of dexamethasone per cell. Specific dexamethasone binding was found to be localized to the cell nucleus. The corneal cells were susceptible to infection with herpes simplex virus (HSV). Dexamethasone increased cell susceptibility to the virus and facilitated the spread of the infection throughout the corneal cell culture. This effect was observed at concentrations of dexamethasone as low as 10(-9) M. Tetrahydrocortisol, an inactive glucocorticoid metabolite that does not compete with dexamethasone binding to the receptor, did not enhance HSV infection at a high concentration (10(-5) M). This study demonstrates a direct effect of dexamethasone on corneal cell-HSV interaction in the absence of exogenous immunologic factors. This effect of dexamethasone may be mediated by the glucocorticoid receptor.

Animals↗
PubMed1981

Tissue reaction to suture materials in infected surgical wounds--a histopathologic evaluation.

Suture materials are foreign bodies which induce and prolong tissue reaction in the wound area. Cellular responses to infected wounds containing 7 suture materials (braided polyglycolic acid [BPGA, Dexon], multifilament stainless steel, monofilament nylon, black braided silk, braided Dacron [Mersilene], and plain and chromic catgut) were studied at 6, 10, 20, and 40 days. Cellular reaction varied with different suture materials. In general, neutrophils were the predominant cells in acute infection, but later, macrophages and fibroblasts predominated. Occasionally, plasma cells, lymphocytes, eosinophils, and giant cells were present. In the infected wounds with implants of plain catgut, chromic catgut, silk, and braided Dacron, there were large numbers of neutrophils even in chronic implantation, indicating persistence of local infection. With nylon, steel, and BPGA, the number of neutrophils rapidly decreased. Although BPGA induced intense acute reaction, the response was mild in chronic implantation. It appeared to be absorbed more slowly than plain or chromic catgut, and tissue reaction was minimal in the absorption stages. A reaction similar to the Splendore-Hoeppli phenomenon was seen around multifilament silk strands in chronic stages of implantation.

Animals↗
PubMed1981

Further studies with polyglycolic acid (Dexon) and other sutures in infected experimental wounds.

Seven suture materials (braided polyglycolic acid [BPGA, Dexon], multifilament stainless steel, monofilament nylon, black braided silk, braided Dacron (BD, Mersilene], and plain and chromic catgut) were implanted in surgical wounds which were inoculated with 3 dilutions of Staphylococcus aureus. The degree of swelling was measured at 6, 10, 20, and 40 days. Monofilament nylon and multifilament steel produced the least amount of swelling; plain and chromic catgut produced the most. The BPGA, BD, and silk caused swellings that were intermediate in degree. In chronic implantations, inflammatory reactions to the various suture materials differed from those occurring soon after implantation. Response to steel and nylon remained minimal; that to silk was gradual, but overall became the most severe. There was slightly less response with BD. The catguts varied little from each other in their responses. Intense reaction was induced by BPGA in the early stages, but the response was mild in chronic implantations.

Animals↗
PubMed1981

Sequential study of lymph node and splenic aspirates during Theileria parva infection in calves.

The development of Theileria parva infection in calves with partially exteriorised spleens was studied. Macroschizont infected cells were detected in the spleen and prescapular lymph node on the same day following inoculation of stabilate in front of the ear, indicating a haematogenous dissemination of the parasite. Macroschizont infection reached a peak on day 14 in the lymph nodes and in the spleen. The time to the appearance of of piroplasms and the development of parasitaemia were similar in the peripheral blood and in the spleen. The packed cell volume and total while blood cell counts from peripheral blood and splenic aspirates both showed similar changes. There was a marked leucopenia, beginning from the onset of the febrile response, and a mild terminal anaemia. The exteriorisation of the spleen caused little distress or change in the calves and provides a useful technique of monitoring splenic responses during the course of disease.

Animals↗