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Biomedical subjects

S Valente

Publications and source records attributed to S Valente.

108 records · Page 6Linked to original sources
PubMed1980

Acute reactive stage proteins in gynaecologic cancers.

The authors report the plasmatic variations of ARPS (acute reactive proteins stage) in fifty eight women, admitted to the Obstetric and Gynaecological Clinic of Padua's University in the years 1978-1979 aged between 35 and 80 years old; those patients were affected by different types of gynaecological neoplasms: twenty three had cervical cancer, eight endometrial cancer, twenty six ovarian cancer. An evident increase was seen in the ARPS in the patients studied. In particular there was an increase in he haptoglobin in the ovarian cancer patients as well as an increase in the alpha-1 antitrypsin in the cervical cancer patients. Regarding ARPS and the clinical stage of the tumour the variations were important between T0 and T1 that is between tumours localized in the affected organ and those outside the primitive site but always in the pelvis. No evident alterations were found between T1 or T2; there was no other increase in the ARPS in neoplasm outside the pelvis.

Adult↗
PubMed1980

Modifications of the coagulation factors during normal and pathological pregnancies.

Levels of fibrinogen and fibrin/fibrinogen degradation products (F.D.P.) have been mesurated respectively by thrombin time and by staphylococcus clumping test in 33 pregnant patients, recovered in the Obstetric and Gynaecological Clinic - University of Padua, during the ninth month of pregnancy. A control group of 16 normal pregnancies, a second group of 12 hypertensive patients, and a third group of 15 pregnancies who had given birth to rather small babies for date, were considered. A significative increase (p less than 0,001) of the F.D.P. values was found both in the pregnant women with hypertension and in those with foetal insufficiency respect to the control group. The fibrinogen levels did not vary in any of the three groups.

Blood Coagulation Factors↗
PubMed1980

Estrogen therapy in menopause and endometrial cancer.

The hormone dependency of endometrial cancer and the increase of its incidence seem to be generally accepted. The Authors expose the results of a four year retrospective epidemiological research aiming at verifying the possible role of menopausal estrogen assumption in the etiopathogenesis of the above mentioned disease. Two groups of post-menopausal patients were examined, who underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy: 168 were endometrial cancer free, 50 were affected. The percentages of estrogen users, the exposition time and type of therapy were carefully analyzed in them. No correlation could be found between estrogen consumption, which resulted much lower than in the U.S.A., and endometrial cancer incidence. The relatively short assumption times, the different drug associations, and the hypoestrogenic origin of the most disturbing menopausal symptoms can help to explain this finding which is however, in agreement with what emerges from studies carried out in different countries by several Authors.

Estrogens↗
PubMed1980

Diagnostic significance of the carcino-embryonal antigen in gynecologic neoplasia.

The carcino-embryonal antigen has been studied in 35 patients affected by malignant gynaecologic neoplasia (cervical, endometrial, vulval) and, for control, in 16 patients affected by small tumors of the genital area. In other 9 patients the day to day variability has been studied. Two determinants, before and after therapy were performed on every patient, and in many cases afterwards. The analysis of the results show the scarce reliability of the episodic C.E.A. determination of the plasma. The use of this parameter in the follow-up of malignant neoplasias gynaecologic can only be reserved in cases with high basic values and in which the therapy reduces the plasmic level significantly.

Carcinoembryonic Antigen↗
PubMedDate not supplied

Determinants of prostate-specific antigen test use in prostate cancer screening by primary care physicians.

OBJECTIVE: To identify determinants of prostate-specific antigen (PSA) test use in prostate cancer screening by primary care physicians. DESIGN: Self-administered, confidential surveys were mailed to 800 Ohio primary care physicians. A second mailing to nonrespondents was sent a month later. Surveys included questions on beliefs, attitudes, knowledge, and reasons for PSA prostate cancer screening. RESULTS: The response rate of usable surveys was 51% (n=408). More than half (55%) of the respondents reported using the PSA test for screening often or always. Multiple regression analysis showed physicians' reported belief that PSA screening is the standard of care in one's community was the strongest direct predictor of use (beta=.32; P<.001). Other direct predictors of PSA test use included physician feeling about the test (beta=.28; P<.001), patient requests for the test (beta=.19; P<.001), age of patient (beta=.11; P< or =.003), and recommendation of specialty or other organizations (beta=.12; P=.001). CONCLUSIONS: Although PSA prostate cancer screening has yet to be proved definitely effective in decreasing mortality or morbidity from the disease, more than half of Ohio primary care physicians surveyed reported regular screening. The rationale for such screening seems to be multifaceted, and, thus, changes in physician behavior probably will be difficult to achieve.

Adult↗
PubMedDate not supplied

[Recurrent bacterial endocarditis on mitral and aortic biological prostheses in young drug addicts. The role of transthoracic cardiac echo-Doppler in the diagnosis and assessment of postendocarditis dysfunction].

Bioprosthetic infective endocarditis is a very serious complication since both medical and surgical treatment is associated with a high mortality. We describe a case of a young drug addict who presented 3 recurrent episodes of bacterial endocarditis of mitral and aortic bioprosthetic valves, caused by different virulent germs. All 3 episodes were resolved by medical therapy, but the residual aortic bioprosthetic dysfunction was important and the patient died before surgical replacement. Which was not considered an emergency since the patient was asymptomatic, did not present heart failure and left ventricular function was preserved. Color-Doppler echocardiography permitted us to visualize the vegetations and to establish and follow the evolution of residual bioprosthetic dysfunction.

Adult↗
PubMedDate not supplied

Short chain fatty acids produced by anaerobic bacteria inhibit adhesion and proliferation of periodontal ligament fibroblasts.

Short chain fatty acids (SCFA) are metabolic by-products of anaerobic bacteria present in the periodontal pocket. We examined the effect of SCFA on cultured human periodontal ligament fibroblasts (PDLF). PDLF were challenged with propionate, butyrate and succinate. A dose dependent inhibition of fibroblast adhesion and proliferation was observed. These results indicate that SCFA present in the periodontal pockets could interfere with periodontal wound healing and repair in patients affected by periodontal infections.

Bacteria, Anaerobic↗