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Biomedical subjects

S Vána

Publications and source records attributed to S Vána.

At least 19 recordsLinked to original sources
PubMed1992

[Surgical treatment of endocrine orbital disease. Indications, methods,results].

Surgical removal of the thyroid gland in Graves-Basedow's disease has, beyond doubt, also a major effect on endocrine orbitopathy. After total or near-total removal of the thyroid gland after three months a slighter deterioration or even ameloriation of ocular protrusion is found, contrary to the effect of subtotal thyroidectomy. There exists a significant correlation between the volume of the residual gland evaluated according to 24 h-uptake of 131I, and between the regression of the protrusion (r = 0.385, p < 0.01). Total or near-total thyroidectomy alone even in the absence of other therapeutic methods leads after 1 to 4 years to an average regression of the protrusion by 1 mm which matches the results of prednisone treatment, if the latter is used as the sole treatment. Orbital decompression by the modified method of Ogura and Walsh led in patients treated concurrently with prednisone and thyroidectomy to improvement of the visual acuity on average by 50% (from the range of 0.008 to 0.33 to values from 0.4 to 1.0) and to regression of the protrusion on average by 3.3 mm. When determining the time of operation of the oculomotor muscles, in addition to the unchanged ocular finding also the echographic picture in sectorial visualization proves useful.

Exophthalmos↗
PubMed1991

[Cardiac function and adrenergic regulation in incipient hypothyroidism].

In patients with thyroid carcinoma who after thyroid elimination took thyroxine and triiodothyronine both hormones were discontinued and after 7 days a complex of peripheral and laboratory parameters was evaluated. Discontinuation of thyroid hormones led to a drop of their serum level and concurrent rise of the TSH level and serum cholesterol. The duration of the pre-ejection period of the systole, the Q-Kd interval and Achilles tendon reflex was protracted. The value of the index of the preejection time increased and that of the index of the expulsion time declined. The heart rate and systolic pressure declined and the body eight increased. Seven-day discontinuation of thyroid hormones did not affect the plasma level of noradrenaline, adrenaline and cyclic adenosine monophosphate. The diastolic pressure and index of electromechanical systole did not change.

Adult↗
PubMed1990

[Subclinical hypothyroidism].

Subclinical hypothyroidism was detected in 5.7% of 853 patients referred for ambulatory examination to a department in Prague. In patients referred with a mild degree of subclinical hypothyroidism with an evaluated level of thyrotropic hormone in serum (TSH) no significant deviations of serum thyroxine and triiodothyronine (T4 and T3) were found nor different values of the Achilles tendon reflex time, as compared with patients with normal thyroid function. In case of a more marked grade of subclinical hypothyroidism with an elevated TSH level without stimulation the patients have on average significantly lower T4 vales, significantly longer Achilles tendon reflex times and preejection stage of left ventricular contraction, and of Rodbard's Q-Kd interval (Q-Kd) than euthyroid patients. The values are, however, still within the reference range for normal function and in individual cases cannot be decisive for establishment of the diagnosis. The authors discuss the differential diagnosis and views on treatment of this disease.

Adult↗
PubMed1989

Influence of thyroid hormone supply on EEG frequency spectrum.

In 5 patients after total thyroidectomy followed by radioiodine ablation the frequency analysis of EEG based on fast Fourier transformation was performed and the results obtained during hypothyroid state and after the substitution treatment with thyroid hormones were compared. During the hypothyroid state the most remarkable finding was the increase of percentage representation of fast frequencies in beta 1 and beta 2 bands, while such values in alpha band including a dominant frequency in that band were reciprocally decreased. After the period of treatment with triiodothyronine during which clinically euthyroid state has been achieved (i.e. decrease of Achilles tendon reflex time, decrease of TSH and of T3 level) no significant changes in the distribution of EEG frequencies spectrum were found, but in all patients a dominant frequency in alpha band was increased at least for 1 Hz. Only after the treatment with thyroxine (Eltroxin Glaxo) the interrelations between individual frequencies of EEG spectrum returned to the normal range and a further increase in dominant alpha frequency was found. The correlation between a dominant frequency in alpha band and thyroxine level in serum was highly significant. These findings are in agreement with our previous observations in 43 subjects where a dominant alpha frequency in healthy controls was always higher than that in hypothyroid subjects and was significantly related to T4 level. The findings of continuing EEG signs of brain hypothyroidism even after achieving of clinical euthyroidism and normal peripheral parameters under increased serum T3 and low T4 level are in full agreement with experimental observations on the importance of local deiodination of T4 in brain tissue and on the risk of hypothyroxinemia.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

Prevalence of thyroid diseases in two samples of Czech population. A preliminary study.

Two preliminary pilot studies of prevalence of thyroid disorders in Central Bohemia (with mild endemy before the onset of iodine prophylaxis in 1948) were made: 1. Questionary survey of adult persons in Praha (1559 persons); 2. Clinical and laboratory investigation of 2015 employees of SKODA automobile works in Mladá Boleslav. Prevalence of thyroid disorders in Praha was 11.99%. In randomly selected subjects from Mladá Boleslav (evaluated in two periods after 10 years) the prevalence of clinically manifested thyroid disorders was 0.35% in men and 2.32% in women, respectively, the presence of positive titres of antithyroglobulin antibodies, varied from 2.43-6.11% of high titres and from 2.35 to 17.33% of low titres. However, the prevalence of goiter was markedly higher than expected, since diffuse goitre was found in 8.36% of men and in 11.34% of women. Even more striking was the prevalence of nodular goitre which was 5.59% in men and 22.96% in women thus making the total goitre prevalence of 13.95% in men and 34.30% in women. In addition, an unfavourable increase of prevalence of nodular goitre was found in younger women in comparison with older group. These results, although preliminary, pointed out the necessity of further more extensive and intensive studies of prevalence of thyroid disorders and of methodology of iodine prophylaxis.

Adult↗
PubMed1979

Labelled amino acids in plasma of patients with thyrotoxicosis and thyroid cancer after radioiodine treatment.

The levels of total organically bound 131I, per cent of labelled iodoproteins, total labelled iodinated amino acids and a percentage of individual iodinated amino acids (thin-layer chromatography) were measured in serum of 84 patients with thyroid cancer and of 16 patients with thyrotoxicosis at 48 h after the administration of therapeutic dose of 131I. In thyrotoxic patients treated with therapeutic doses of 131I (2 to 39.6mCi; 74 to 1500 MBq) the findings were similar to normal subjects. In patients with thyroid cancer a significant increase of iodotyrosines was found after thyroid radioiodide ablation (100 to 200 mCi; 3.7 to 7.4 GBq). No remarkable differences were found between two groups of patients with thyroid cancer, the first one being treated with thyroid eliminating dose in attempt to activate the metastases of functionally differentiated tumour, while the second one was treated with similar doses (i. e. 100 to 200 mCi) to suppressor destroy a functionally active tumour or its metastases. Even though the hormonogenesis in tumours was hardly distinguishable from the products of its radiation damage, it was suggested that the hormonogenesis in neoplastic tissue differs from that in normal thyroid only quantitatively, being less in patients with thyroid cancer than in these with thyrotoxicosis.

Amino Acids↗
PubMed1979

Functional activity of a thyroid nodule under the influence of stable iodide administration in a hyperthyroid patient.

In a thyrotoxic patient with nodular goiter treated with stable iodide and Carbimazole, a series of 131I scans was performed at different intervals for proposed 131I therapy. Originally, total uptake was suppressed and the node was evaluated as active. The same type of scan was seen repeatedly with uptake increasing for about 6 months following stable iodide withdrawal. Only 9 months later, the effect of 127I disappeared and uptake rose considerably with a reversal of the scan to the picture of a hypofunctioning node. The same distribution was found after therapeutic 131I administration. 6 months following treatment, without any thyrostatic drugs, the patient was euthyroid and on the scan most of tracer was found in the node. It is believed that this change is best explained by the different sensitivity of the nodule and the paranodular tissue to the effect of stable iodide. It is believed that the hyperthyroidism originated in the paranodular tissue highly sensitive on the 127I, while the nodule (presumably an adenoma) was less sensitive and showed uptake only when the paranodular tissue was depressed by 127I or, later, injured by the effect of therapeutic 131I.

Carbimazole↗