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Biomedical subjects

S V Naletov

Publications and source records attributed to S V Naletov.

7 recordsLinked to original sources
PubMed1992

[The antiemetic activity of buspirone].

The low activity of conventional antiemetic drugs by chemotherapy of oncological diseases has determined the necessity to evaluate the activity rate of 5-hydroxytryptamine receptors' agonists. Experimental data show, that buspirone exceeds significantly all the used antiemetics what allows to expect its high activity in the clinic.

Animals↗
PubMedDate not supplied

[The safety of pyricapirone--a new psychotropic and antiemetic agent].

Acute and chronic toxicities of Pyricapirone, a new psychotropic and antiemetic agent, as a substance and a dosage form (ampoule solution) were studied in experiments on animals (mice, rats, rabbits, and dogs) during various routes of administration (intraperitoneally, subcutaneously, and orally). In terms of acute toxicity, Pyricapirone was found to be low toxic and belongs to toxicity class IV compounds. Pyricapirone showed no accumulative properties. During chronic administration, the agent produced moderate hepatic and renal toxic effects which were reversible; all the detected functional and morphological changes underwent a reversible development during a month rehabilitative period.

Animals↗
PubMedDate not supplied

[The possible neurochemical mechanisms of the neuroleptic action of buspirone-like serotonin agonists].

The experiments on animals (rats and mice) and pigeons have established that buspirone and other serotonin agonists such as 1-(2-pyrimidinyl)-piperazine derivatives such as ipsapirone (TVX Q 7821), levopirone, kampirone, and sepirone have some pharmacological properties which are typical of neuroleptics. The serotonin agonists under study accelerate rat brain dopamine metabolism show their antagonism with apomorphine in the stereotypy and climbing tests in mice, suppress the conditioned avoidance reflex in rats, and eliminate apomorphine-induced vomiting in pigeons. Serotonin agonists, like serotonin, have been shown to stimulate the impulse-dependent release of 3H-dopamine from the slices of the rat nucleus accumbens and striatum. The capacity of buspirone and other serotonin antagonists of modulating dopamine release is not eliminated by 1A/B and 2 serotonin antagonists such as propranolol (3 microM) and metesergide (1 microM), but it is inhibited by ICS 205-930, a selective antagonist of 3HT receptors.

Aggression↗