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Biomedical subjects

S V Kessing

Publications and source records attributed to S V Kessing.

9 recordsLinked to original sources

Limbus-based versus fornix-based conjunctival flap in glaucoma filtering surgery.

Eighteen consecutive patients suffering from the same type of glaucoma in both eyes were treated with bilateral trabeculectomy. Surgery with both fornix-based and limbus-based flap was performed on each patient, one procedure in each eye. Pre- and postoperative intraocular pressure, morphology of the fistulation bleb, anterior chamber depth and need for additional treatment were recorded. Half a year after surgery, the fornix-based flap procedure was superior (p < 0.05) concerning high success rate, little additional therapy and good morphology of the bleb.

Adult

Congenital ectopia lentis and secondary buphthalmos likely occurring as an autosomal recessive trait.

A family from Turkey with congenital ectopia lentis, likely occurring as an autosomal recessive trait, is presented. No systemic disorders such as homocysteinuria, Marfan's or Weill-Marchesani's syndromes were found in any of the patients. However, all patients except one were less than 2 years old when first examined so that lens luxation must have happened very early in life. Besides almost total lack of zonular threads the patients presented anomalies of ocular dimensions with increased corneal diameters and axial lengths, and in several cases glaucomatous distension of the optic discs could also be found. A possible explanation for these buphthalmic changes and their relation to lens luxation taking place very early in life is proposed. The importance of early diagnosis and treatment is discussed.

Child

Evaluation of the retinal nerve fiber layer in early glaucoma. Physiological and pathological findings.

In this study on retinal nerve fiber layer (RNFL) evaluation in early glaucoma we investigated whether the greatest retinal vein width is a usable measure to distinguish physiological findings from beginning pathological defects. Seven normal control eyes and 23 glaucomatous eyes with small relative Octopus defects (greater than 10 db and less than 20 db) were photographed. In the control group 3 eyes had no RNFL loss, 4 eyes had localized defect less than 1 vein width. In the glaucoma group 1 eye had a localized defect less than 1 vein width, 7 eyes had localized defects greater than or equal to 1 vein width and 12 eyes had diffuse defects. Based on the present study it seems reasonable to define small localized defects as pathological if they at any point are greater than or equal to 1 vein width. According to this definition our study showed a specificity of 100% and sensitivity of 95% which means that the method is usable as an extra parameter in the diagnosis of early glaucoma.

Adolescent

[Eye care in Greenland in 1979-1988].

Specialist eye care in Greenland is described on the basis of 66 reports from all 30 visiting consultants during a ten-year period. During this time the durations of the visits increased to approximately seven months per year for 8-9 ophthalmologists who undertook approximately 2,500 consultations annually. The diagnoses were distributed as follows: 30% anomalies of refraction, 15% cataract, 12% conditions in the posterior segment and 10% glaucoma, i.e. a considerable proportion of eye diseases associated with advancing age and with a particular Greenlandic influence. The workload was particularly great and averaged more than a reasonable weekly load despite the increase in number of days of employment. Until 1985-1986, eye surgery activities showed a considerable increase after which operative interventions for cataract and glaucoma were mainly referred to Rigshospitalet. The great increase in the number of referrals is discussed in relation to the marked changes in the therapeutic possibilities for cataract and glaucoma: extracapsular cataract extraction with posterior chamber implantation using an operation microscope and YAG-laser iridectomy of early angle closure glaucoma. The requirement of an eye surgical unit in Greenland appears to be pressing together with continuation of specialist eye care in the districts.

Aged

Panretinal xenonphotocoagulation combined with cyclocryotherapy in the treatment of severe glaucoma.

In 12 eyes with glaucoma (none of them neovascular and all eyes with vision) which had proved resistant to conventional types of medicine and surgery, a panretinal xenonphotocoagulation (XPRP) reduced intraocular pressure (IOP) from an average of 30 mmHg to 20 mmHg measured 3/4 month after the treatment. After cyclocryotherapy of the 2 lower quadrants (CCR), IOP, after an initial fall, had risen to pre-treatment values after a similar interval. XPRP followed by CCR had an especially strong and lasting IOP reducing effect. The combination was less painful than CCR alone, even if both generally had to be repeated. We suggest that XPRP potentiates the damage of the secretory epithelium made by CCR, by strangling the posterior (long ciliary) blood supply of the ciliary body. IOP measured 2 1/2 years after the treatments averaged 18 mmHg (range 11-22). Phthisis did not develop in any of the eyes.

Adolescent

Congenital glaucoma before and after the introduction of microsurgery. Results of "macrosurgery" 1943-1963 and of microsurgery (trabeculotomy/ectomy) 1970-1974.

Primary trabeculotomy (in five eyes "converted" to trabeculectomy) normalized the tension in all 21 eyes with congenital glaucoma without associated diseases, (mean postoperative tension 12 mmHg, range 8-20 mm). Re-operation was needed for only one eye. Preoperatively glaucomatous cupping was present in 18 of these 21 eyes. Ten of the 18 eyes with glaucomatous cupping were operated upon before the age of 6 months two before 11 months and the appearance of the disc was normalized in these 12 eyes. Repeated trabeculotomy, -ectomy was without success in three of five operated eyes in patients with congenital glaucoma of several years duration previously treated by "macrosurgery". In patients with associated diseases normal tension was achieved by means of trabeculotomy/-ectomy in two eyes in two Sturge-Weber children with unilateral congenital glaucoma and in both eyes in a child with a chromosomal defect with bilateral congenital glaucoma. Repeated trabeculotomy/ectomy was on the other hand without success in a child with bilateral aniridia with congenital glaucoma and hydrocephalus. Presupposing acute or subacute microsurgery, the present operative results of congenital glaucoma without diseases are far better than those obtained in previous decades by "macrosurgery" which, despite frequent re-operations, effected normalization of the tension in only 61% of the eyes (11 of 26 patients (42%) with bilateral congenital glaucoma without associated diseases and treated by macrosurgery in previous decades were under the Care of the Blind).

Denmark

The distended disc in early stages of congenital glaucoma.

In 12 out of 18 eyes operated upon for congenital glaucoma without associated diseases the preoperative glaucomatous cupping had disappeared at follow-up 2 weeks to 3 months after the operation (trabeculotomy ab externo on 9 eyes and trabeculectomy on 3 eyes). Of the 12 eyes, 10 had had the operation performed before the age of 6 months, in contrast to the group in which glaucomatous cupping of the disc was irreversible where operation had been performed in the age range 6 months--12 years (mean 6 years). The mean postoperative tension value in the 18 eyes was 12 mm (range 8-20) mm) without medication, mean observation time 3 years. It seems likely that during the first phases of congenital glaucoma the disc is distended, i.e. of increased diameter and depth. This form of glaucomatous cupping and the increased diameter of the disc may be due to pressure-conditioned enlargement of the scleral canal and omnidirectional distention of the lamina cribrosa. This distention manifests itself mainly in the central areas of the lamina cribrosa and the disc, and usually disappears when the tension is normalized by surgery during the first phases of the disease.

Child

Aphakic glaucoma.

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Aphakia, Postcataract

Conjunctival goblet cells in patients with cystic fibrosis.

In five patients with cystic fibrosis of the pancreas the mucous glandular system of the conjunctiva was studied, as changes, if any, in the conjunctival goblet cells might be applicable as a diagnostic test in questionable cases. A whole-mount technique was used, specially developed for studying conjunctival goblet cells. In all five cases the qualitative as well as quantitative goblet-cell findings were in accordance with a previously reported normal material. In particular, there were no signs of stagnated secretion.

Child