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Biomedical subjects

S Umeki

Publications and source records attributed to S Umeki.

146 records · Page 9Linked to original sources
PubMedDate not supplied

Adverse effects of antitubercular drugs and significance of measurement of the drug-stimulating lymphocyte transformation rate.

An analysis of the adverse effects appearing in 101 patients during at least 4 months of chemotherapy for newly detected pulmonary tuberculosis between September, 1985 and July, 1987 was performed. These patients received isoniazid, rifampicin and ethambutol daily (HRE) or isoniazid and rifampicin daily, and streptomycin three times weekly (HRS3). Adverse effects appeared in 90 patients (90%). Of the 101 patients, 53.5% experienced eosinophilia, 42.6% itching, 25.7% eruption and 19.8% liver damage. Of 25 patients receiving streptomycin, 13 (52%) experienced tinnitus. Liver damage appeared more frequently in males than females. Neutropenia occurred in 31.0% of females, but in only 2.8% of males. In patients who developed severe but reversible adverse effects, such as liver damage, skin eruption and neutropenia, evaluation of the drug-stimulating lymphocyte transformation rate (DLTR) was performed. The results suggest that evaluation of the DLTR may be useful in determining which drugs may cause adverse effects, including liver damage, skin eruption and neutropenia.

Adult↗
PubMedDate not supplied

Clinical features of pulmonary tuberculosis in young and elderly men.

A comparison of the clinical features, predisposing factors, side effects by antitubercular drugs and diagnostic procedures in pulmonary tuberculosis in 37 younger and 35 elderly men was carried out. Elderly patients had a higher number of underlying diseases including cardiovascular diseases and hypertension than younger patients. The classic symptoms and signs of tuberculosis, such as productive cough, fever and general fatigue, were observed in relatively high proportions of both patients, whereas weight loss (43% vs. 16%) and crackles in the lung fields (49% vs. 16%) were significantly higher in the elderly patients than the younger ones. As for roentgenographic abnormalities, a higher involvement of middle and lower lung fields was seen in the elderly patients than in the younger. Although leukocytosis was noted in a significantly lower proportion of the elderly patients, neutropenia due to drug treatment was significantly higher (23%) than in younger patients (5%). In a mass survey, the detection of pulmonary tuberculosis in elderly men was significantly lower (23%) than that in younger men (54%). Although improved living conditions, better sanitation and the development of new chemotherapeutic agents have contributed to the decline of pulmonary tuberculosis in general populations, better procedures for early detection or diagnosis of pulmonary tuberculosis in the elderly people should be achieved as soon as possible.

Adult↗