[65th birthday of Prof. Adolf Windorfer, M.D].
Explore the source record for details and available documents.
Germany, West↗
Biomedical subjects
S Ulrich
Publications and source records attributed to S Ulrich.
Comparative studies of the respiratory function of mammalian blood. V. Insectivora: shrew, mole and nonhibernating and hibernating hedgehog.
Explore the source record for details and available documents.
Animals↗
[Computerized tomography in paleopathology].
Paleopathology is the study of human ailments in bygone times of which written records are non-existent or inadequate. Essentially, it is based on osteological findings. Radiologic examination, which reveals the inner structure of the bones, plays an important role. Additional information can be obtained with CT, primarily because there is no superimposition of the bones. The very detailed radiologic demonstration of a periosteal reaction on a tibia in a case of acquired syphilis is illustrated.
Bone and Bones↗
[Brain-specific creatine kinase (CKBB) in umbilical cord blood. A prognostic parameter in chronic intrauterine hypoxia?].
Elevated levels of brain type creatine isoenzyme (CKBB) have been demonstrated in serum after brain cell injury in neonates. A hypoxic lesion of the membrane permeability of the CKBB rich brain cells may lead to an increased enzyme leakage into the serum. As an increased release from the fetal brain as a result of intermittent compression and decompression of the fetal head during labour and after rupture of membranes may occur without hypoxic damage, only pregnancies which were terminates by cesarean section were studied. No mother went into first stage of labour and no rupture of membranes occurred. Three study groups were defined. The control group (elective cesarean section for breech presentation) showed CKBB enzyme activities below 15 U/l. A group with emergency cesarean sections had low CKBB values too, despite acidotic pH-values (pH < 7.20) at birth. The third group included fetuses which were delivered by cesarean section because of a pathological fetal heart rate tracing and intrauterine growth retardation. 6 out of 40 umbilical cord sera in this group showed elevated CKBB enzyme activities. If there was an additional fetal acidosis an increased neurological morbidity and neonatal mortality was seen.
Asphyxia Neonatorum↗
[Fetal development in mild and severe pre-eclampsia: correlation with maternal laboratory parameters and Doppler ultrasound].
During three and a half years we observed 83 single pregnancies all delivered by caesarean section. All of them had a mild (systolic blood pressure > 140, diastolic > 90 and proteinuria > 0.5 g/dl) or a severe preeclampsia (systolic blood pressure > 160, diastolic > 100 and proteinuria > 3.0 g/dl). We found significantly twice as many abnormal uteroplacental blood flow velocities in the severe preeclampsia group than in the mild one. These results draw us to the conclusion that possible pathological changing of the vessels is due to preeclampsia which does not need to correlate with a placental insufficiency and fetal growth retardation. An abnormal uteroplacental blood flow velocity connected with an abnormal umbilical blood flow velocity raises the fetal morbidity and the early childhood morbidity. Fetal outcome in mild compared to severe preeclampsia definitively shows a worse prognosis for those fetuses whose mother developed a prepartal severe preeclampsia. A distinctly increased rate of cerebral haemorrhages, abnormal neurological signs, acute respiratory distress syndromes and bronchopulmonary dysplasia was found. Finally we show an additional risk for fetal outcome in absent or reverse enddiastolic flow velocity (AREDFV) in the severe preeclampsia group. We observed in the AREDFV group with severe preeclampsia in comparison to a group of AREDFV without maternal preeclampsia more than twice as many cerebral haemorrhages, abnormal neurological signs and bronchopulmonary dysplasia.
Adult↗
[Blood flow profile in the uterine artery. Correlation with placental morphology and clinico-obstetrical data within the scope of pre-eclampsia].
Within a group of preeclamptic women we found severe histologic placental pathology with functional relevance when both the uteroplacental and fetoplacental flow velocity waveforms showed elevated resistance indices. These pathological findings were a reduced decidual area, infarction and villus maturation failures with a high rate of intrauterine growth retardation, acidosis and premature delivery. In cases with normal flow velocity waveforms these pathologic findings were much rarer although the patients were preeclamptic, too.
Arteries↗
Langerhans cells in epithelial tumors and benign lesions of the oropharynx.
Hyperplastic lesions of the oral mucosa such as leukoplakia and oral lichen planus can eventually develop into squamous cell carcinomas. The development of carcinomas may be the result of the interaction of genetic factors, carcinogens and an impaired immune response. The presence of S-100 positive Langerthans cells in normal mucosa, premalignant and malignant lesions of the oral mucosa was investigated by immunohistology. Quantitative analysis showed that in benign lesions of the oral mucosa the average number of S-100 positive cells was much higher than in normal mucosa. In the neoplastic lesions the number of S-100 positive cells was in general lower than in the benign lesions and decreased even more with loss of differentiation. The data suggest that the infiltration of dendritic cells increases in benign lesions of the oral mucosa, implying a normal immunostimulatory potential, and decreases in malignant lesions in relation to the loss of differentiation in the tumors.
Antibodies, Monoclonal↗
[Late neurologic morbidity of premature infants with intrauterine diagnosis of null- or negative flow of the umbilical arteries].
Absent or reverse enddiastolic flow velocities (AREDFV) of the umbilical arteries are associated with fetal distress and adverse fetal outcome. We studied 68 fetuses with AREDFV with respect to abnormal neurological evaluation up to two years. A control group was matched for gestational age and had normal umbilical artery flow velocity waveforms. Fetuses with AREDFV showed increased abnormal neurological signs, compared with the control group (31% vs. 12%). Our results confirm the significance of AREDFV in growth retarded infants with respect to neurological development in early childhood.
Blood Flow Velocity↗
[Doppler sonographic flow measurements of the middle cerebral artery in end-diastolic zero flow in the umbilical arteries in relation to fetal outcome].
Absent or reverse end-diastolic flow velocities (AREDFV) of the umbilical arteries are associated with fetal distress. We studied 74 fetuses with AREDFV with respect to the resistance index of the middle cerebral artery (MCA). The change in the resistance index of MCA was applied to the fetal outcome. The fetuses were retrospectively divided into 3 groups: 1) The fetuses in the first group did not show any changes in the course of observation of the MCA. 2) In the second group a drop followed by an increase in the resistance index of the MCA was confirmed. This is known in literature as "cerebral oedema". 3) The third group showed only a drop in the resistance index, described in literature as "brain-sparing-effect". The increase in the resistance index of the MCA points to a danger for the fetus, since the incidence of fetal acidosis, low birth weight, severe idiopathic respiratory distress syndrome in these fetuses was extremely high. In particular every second fetus in this group showed neurological complications. The change in the cerebral perfusion known as "cerebral oedema" which is extremely dangerous for the fetus has to be avoided.
Adult↗