Search PubMed⌕ Search

Biomedical subjects

S Ullman

Publications and source records attributed to S Ullman.

At least 127 records · Page 7Linked to original sources
PubMed1977

Immunological and chromosomal studies in a patient with Sézary syndrome.

A patient with the small-cell variant of Sézary syndrome was studied before and during treatment with low-dose chlorambucil. He had depressed responses to phytohemagglutinin (PHA) and concanavalin A that returned to normal with clinical improvement. Spontaneously dividing cells were found in the peripheral blood by culturing lymphocytes without PHA for 24 hours. Seventy-two-hour PHA-stimulated lymphocyte cultures revealed predominantly hypodiploid chromosome numbers. Both abnormalities improved during treatment. Lymphocytes that were studied for sister chromatid exchanges had an increased number of exchanges per metaphase. Immunofluorescence studies revealed immunoglobulins and C at the dermoepidermal junction and in the dermal vessel walls. Our findings demonstrate that the depression of mitogen responsiveness that is sometimes seen in Sézary syndrome can be favorably affected by chemotherapy. Likewise, some chromosomal abnormalities may regress during successful therapy. These findings may provide a way of measuring the response to therapy.

Chlorambucil↗
PubMed1977

Vasculitis in granuloma annulare: histopathology and direct immunofluorescence.

Biopsy specimens from patients with granuloma annulare were studied by conventional light and immunofluorescence microscopy. In six of 20 patients, IgM was present in blood vessels of involved skin, and C3 was present in blood vessels in ten of 20 patients. In addition, IgM, C3, or fibrinogen were observed at the dermal-epidermal junction of eight patients. Necrobiotic areas contained fibrinogen. A retrospective histopathologic study of 38 biopsy specimens from other patients with granuloma annulare showed blood vessels with vessel wall necrosis, fibrinoid change, thickening, or occlusion in most specimens. Nuclear dust and extravasation of RBCs were also noted. These findings suggest that an immunoglobulin-mediated vasculitis may be involved in the pathogenesis of granuloma annulare.

Adolescent↗
PubMed1977

Necrobiosis lipoidica. An immunofluorescence study.

Biopsy specimens from 12 patients with necrobiosis lipoidica (diabeticorum) were studied by direct immunofluorescent microscopy. The immunoglobulin IgM was present in blood vessel walls of involved skin from six patients, and the third component of complement (C3) was present in the blood vessel walls of involved skin from seven patients. The immunoglobulin IgA was similarly observed in two patients. In addition, IgM, C3, or fibrinogen were observed at the dermal-epidermal junction of involved skin from seven patients. Necrobiotic areas invariably contained fibrinogen. These findings suggest that an immunecomplex vasculitis may be involved in the pathogenesis of necrobiosis lipoidica.

Adolescent↗
PubMed1976

Skin changes in graft-vs-host disease.

In this review of the clinical and histopathologic manifestations of the graft-vs-host reaction, the characteristic changes in the skin are given particular emphasis, since they are among the earliest and most obvious signs of this syndrome. The acute and chronic forms of graft-vs-host disease are distinguished, with notation of their different dermatologic presentations. The distinctive histopathologic and immunopathologic findings of the graft-vs-host reaction in the skin are presented. Finally, the possible pathogenetic mechanisms which produce the clinical picuture of graft-vs-host disease are discussed. Both T cells and B cells apparently are involved, as are macrophages, but what is primary and what is secondary in the reaction remains to be delineated, as do the respective contributions of donor and host cells.

Adolescent↗
PubMed1976

Parallel studies on collagen hydroxyproline and hydroxylysine in human skin biopsies.

Studies on hydroxyproline and hydroxylysine, the two amino acids characteristic of collagen and related glycoproteins, were undertaken on biopsies of pathologic and clinically normal human skin. No statistically significant differences between clinically normal skin of mamma, thorax, axilla, femur, hip and sacral area were found. A decreased collagen content was seen in chronic pemphigus (bullous pemphigoid), amyloidosis, scleromyxedema and the edge of a leg ulcer. Determination of both amino acids is considered necessary to characterize alterations of collagen.

Adult↗
PubMed1975

Deposits of immunoglobulins and complement C3 in clinically normal skin of patients with lupus erythematosus.

Deposits of immunoglobulins and/or complement C3 were found in two-thirds of biopsies from clinically normal skin of 64 patients with systemic lupus erythematosus, as judged by well defined criteria. The incidence of deposits in clinically normal skin was identical in patients with and without clinical skin lesions. IgM was found more frequently in the deposits (88%) than was IgG (36%) but equally frequently in involved and uninvolved skin, whereas C3 was found more often in patients with skin lesions (59% in involved skin, 36% in uninvolved skin) than in patients without skin lesions (14%). The occurrence of IgG and IgA was less frequent than that of C3 but the distribution was similar to that of C3. In normal skin of 20 patients with chronic discoid LE, deposits were found in one. Deposits were found in the skin of one-third of patients with nuclear antibodies in their sera and symptoms compatible with SLE but with a score of symptoms too low to meet the criteria.

Adolescent↗
PubMed1975

DNA-antibodies in sera from patients with systemic lupus erythematosus.

DNA-antibody determinations using the Farr technique and LE cell tests were performed on single serum samples from 55 patients with SLE according to well defined criteria. It was found that the DNA-antibody test was just as sensitive as the LE cell test, and studies of sera from patients with questionable SLE, discoid LE, other connective-tissue diseases, psoriasis, and from healthy persons, indicated that the DNA-antibody test is highly specific for SLE. Neither the DNA-antibody test nor the LE cell test could discriminate between SLE patients with active and inactive disease as estimated by clinical criteria or by the serum concentrations of complement C3 and C4.

Antibodies, Antinuclear↗
PubMed1975

Anti-basement membrane antibodies in sera from patients without bullous pemphigoid.

Sera from 208 individuals were examined for antibasement membrane (anti-BM) antibodies by means of an indirect immunofluorescence technique. In sera from patients with bullous pemphigoid 19 of 25 had anti-BM antibodies in titres varying from 80 to 32 000. In 2 of 42 sera from patients with psoriasis, anti-BM antibodies were demonstrated (titres 40-640). Of 58 sera from patients with leg ulcers, antibodies were found in 4 (titres 40-320). Antibodies were found in 2 of 43 patients with cardio-vascular disease (titre 80) and in 1 of 40 control persons (titre 40). Serum from one of the patients with leg ulcers caused a punctate staining pattern unlike the tubular pattern seen in all other positive sera.

Animals↗
PubMed1975

Deposits of immunoglobulins and complement in the dermoepidermal junction of patients with anaphylactoid purpura.

Skin biopsies from 3 patients with anaphylactoid purpura examined by an immunofluorescence technique revealed deposits of immunoglobulins, complement C3, and fibrinogen in the dermo-epidermal junction and in vessel walls of clinically involved as well as uninvolved skin. The deposits in the dermo-epidermal junction are similar to those seen in the skin of patients with systemic lupus erythematosus.

Aged↗
PubMed1975

Asymptomatic male and female gonorrhoea.

Three hundred and ninety-nine patients attending the out-patient clinic of the Department of Dermatology and Venereology, Rigshospital, Copenhagen, for various venereal complaints were examined during a three-month trial. Neisseria gonorrhoeae was found in 75 female and 89 male patients. 43 women (57%) and 13 men (15%) were asymptomatic at the first visit. The duration of the asymptomatic period exceeded 3 weeks in 25 female (33%) and 7 male (8%) patients. The asymptomatic period in the male group varied from 15 to 90 days and from 4 to 180 days in the females. The majority of the patients with asymptomatic gonorrhoea had been exposed to a sexual contact with proven gonococcal infection, thus emphasizing the importance of contact investigation.

Adolescent↗