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Biomedical subjects

S Tsuji

Publications and source records attributed to S Tsuji.

At least 955 records · Page 53Linked to original sources
PubMed1983

Congenital coronary arterial aneurysm without arteriovenous fistula resulting in myocardial infarction--case report and review of the literature.

A 38-year-old woman with coronary arterial aneurysm, which resulted in myocardial infarction, was reported. By coronary arteriography, an aneurysm of the left anterior descending branch was found, but no arteriovenous shunt could be revealed. The patient has neither clinical history of severe febrile inflammatory disease nor any coronary risk factors. The etiology of her coronary arterial aneurysm was considered to be congenital. The patient underwent aorto-coronary saphenous vein bypass graft surgery successfully. We believe that this is the first case report in Japan on congenital aneurysm of the coronary artery without arteriovenous fistula, which was diagnosed during life by coronary arteriography.

Adult↗
PubMed1983

Induction of ornithine transcarbamylase activity with egg yolk in chick kidney.

The present paper shows the effect of egg yolk on chick kidney ornithine transcarbamylase (OTC) activity. A 90% egg yolk diet resulted in an increase of about 2.5-fold in kidney OTC activity. Enzyme activity increased gradually during incubation and after hatching and then decreased in accordance with disappearance of egg yolk from the residual yolk sac. Maximum activity - 10-fold that of the 14th day embryo - was observed between Days 4 and 7 in chicks fed the control diet. This maximum was shifted to between Days 14 and 21 and to a higher level by feeding a 90% egg yolk diet. Feeding the egg yolk diet to 14- or 21-day-old chicks that had received commercial chick starter from Day 2 also caused an increase of OTC activity. It was suggested that egg yolk or an ingredient(s) induces chick kidney OTC and that utilization of egg yolk promotes the formation of OTC in chick kidney during embryonic development and during subsequent growth of the chick.

Animals↗
PubMed1983

[Clinical evaluation for T-1982 (cefbuperazone) in the field of pediatric infection].

T-1982 (cefbuperazone), a new injectable cephamycin antibiotic, was employed for bacterial infections in children, and the following results were obtained. 1. When administered intravenously at a dose of 20 mg/kg to a 6-year-old female child, serum levels were 62 micrograms/ml at 30 minutes, 39 micrograms/ml at 1 hour, 17.6 micrograms/ml at 2 hours, 6.8 micrograms/ml at 4 hours and 2.9 micrograms/ml at 6 hours with serum half-life (T 1/2) of 76 minutes. Urinary excretion rates were 41.0, 5.3% and 2.4% respectively at 0-2, 2-4 hours and 4-6 hours, and urinary levels were 820 micrograms/ml, 182 micrograms/ml and 310 micrograms/ml, respectively. The total urinary recovery within 6 hours was 48.7%. 2. A total of 11 cases of pediatric infections was treated with T-1982. The clinical efficacy evaluated for 9 cases, excluding 2 cases of non-bacterial infections, was as follows; excellent in 4, good in 1 out of 5 cases of pneumonia, good in 1 case of cervical purulent lymphadenitis, and excellent in 1, good in 1, poor in 1 out of 3 cases of urinary tract infection. 3. As side effect, mild diarrhea in 1 case and slight elevation of GOT, GPT in 2 cases were observed. 4. These results suggest that T-1982 is of good use for bacterial infections in children and the expected efficacy is obtained at a dose of 20 mg/kg 3 times a day.

Anti-Bacterial Agents↗
PubMed1982

Purification of an endogenous 68,000-dalton inhibitor of Ca2+-activated neutral protease from chicken skeletal muscle.

An endogenous inhibitor of Ca2+-activated neutral protease has been purified from chicken skeletal muscle. The inhibitor, which was isolated by acid treatment and four subsequent chromatographic procedures, is a protein composed of a single polypeptide having a molecular weight of 68,000. It contains large amounts of glycine, proline and glutamic acid but the contents of aromatic amino acids are low. The inhibitor appeared to act on Ca2+-activated neutral protease in a stoichiometric manner, suggesting a complex formation. The inhibitory action was not caused by sequestering of Ca2+. The inhibitor did not inhibit other well-known thiol proteases, but was slightly effective for trypsin.

Amino Acids↗
PubMed1982

Neuraminidase deficiency and accumulation of sialic acid in lymphocytes in adult type sialidosis with partial beta-galactosidase deficiency.

Neuraminidase deficiency has been demonstrated in cultured skin fibroblasts of patients who have adult type sialidosis with partial beta-galactosidase deficiency. A substantial amount of residual enzyme activity has been observed in leukocytes, however. To explain this discrepancy, the nature and distribution of the enzyme were studied. Neuraminidase activity was higher in lymphocytes than in granulocytes of normal controls. In patients' lymphocytes, neuraminidase activity was profoundly decreased and total sialic acid contents were increased 2.3-fold. Two neuraminidases, one sonication-labile and the other sonication-stable, were found in lymphocytes; the former was predominant in cultured skin fibroblasts. The defective enzyme in this disorder was found to be the sonication-labile neuraminidase in both cultured skin fibroblasts and lymphocytes.

Cerebellar Ataxia↗
PubMed1982

On the development of the adult electric organ in the mormyrid fish Pollimyrus isidori (with special focus on the innervation).

The adult electric organ of the mormyrid Pollimyrus isidori consists of four longitudinal tubes, two dorsal and two ventral ones, entirely filling the space in the caudal peduncle, as in other mormyrids. Each tube comprises about 100 electrocytes possessing a large innervated stalk just behind their posterior faces. The numerous nerve terminals are deeply embedded into the surface of the stalk. The electrocytes begin to differentiate in 10-11 mm long fish (about 20 days old); they are initially arranged myotomically. The electromotoneurons are seen for the first time in 9.5 mm long fish (about 16 days old). In 12 mm long fish many putative nerve fibres are found surrounding the stalk, but it is only in 15-15.5 mm fish that nerve terminals establishing typical synapses (synaptic vesicles, synaptic cleft about 80 nm wide, and active zones) are first found. This coincides with the recording of the first electric discharges of the adult electric organ. At this stage the electrocytes are well developed, kidney-like and highly compressed, arranged in parallel in the caudal peduncle. Subsequently the number of nerve terminals increases, the terminals become more deeply invaginated into the membrane of the stalk, the myelin sheath terminating just at its surface. In 19 mm fish the first indication of penetrating stalks at the periphery of the electrocytes can be detected. With increasing length of the larvae the amplitude of the electric discharge also continuously rises. The electrocytes are acetylcholinesterase-positive, the activity is more pronounced over the stalk and the anterior face shows higher activity than the posterior face, mainly those at the periphery, where the penetrating projections are seen.

Acetylcholinesterase↗
PubMed1982

Spinal and cortical somatosensory evoked potentials in Japanese patients with multiple sclerosis.

Twenty-seven Japanese patients with multiple sclerosis (MS) were studied by recording the spinal and cortical somatosensory evoked potentials (SEPs) in response to median nerve and/or posterior tibial nerve stimulation. The median nerve SEPs were abnormal in half the cases whereas the tibial nerve SEPs were abnormal in 90% of cases. SEP abnormalities, especially absence or amplitude depression of components, were highly correlated with proprioceptive impairment of hands or legs tested. With regard to the usefulness of SEP in detecting subclinical lesions of the sensory system, the tibial nerve SEP was found more useful than the median nerve SEP. Absence or depressed amplitude of SEP components was seen more commonly with tibial nerve stimulation as compared with median nerve stimulation.

Adult↗
PubMed1982

The bioavailability of diazepam from uncoated tablets in humans--Part I: correlation with the dissolution rates of the tablets.

Dissolution studies of 15 preparations of commercial uncoated tablets of diazepam (5 mg) were performed by six methods (beaker, rotating basket, oscillating basket, solubility simulator, rotating flask, and single basket). Diazepam dissolved rapidly at pH 1.2; the T50 (the time of 50% dissolution) values were less than 5 min. But at pH 4.6, T50 estimated by rotating basket method lasted 3-120 min. Four different tablets of diazepam were chosen for the bioavailability tests in humans. The bioavailabilities of the four tablet preparations were estimated by serum level measurements after a single dose to 12 adult male volunteers. Statistical analysis of the data showed significant differences in the rate of bioavailability (peak concentrations and serum concentrations at 1, 2, and 3 h after administration), but not in the amount of available (AUC). The mean peak concentration and serum concentration at 1 h showed significant correlation with T50 and T70 determined by the rotating flask method at pH 4.6 in log-log regression. The peak concentration and serum concentration at 1 h were also correlated with T70 determined by the rotating flask method at pH 4.6 and T70 determined by the rotating basket method at pH 4.6 on normal-normal regression. In contrast, the dissolution rates determined at pH 1.2 did not show a good correlation with in vitro parameters.

Adult↗
PubMed1982

Surgical monitoring of spinal cord function: cauda equina stimulation technique.

Spinal cord and subcortical brain stem evoked potentials had an amplitude at least 2 times higher when the cauda equina rather than bilateral peripheral nerves was stimulated. Cauda equina stimulation is indicated when potentials to peripheral nerve stimulation are absent or are too low in amplitude to permit reliable surgical monitoring. The technique is essentially without risks, but should be performed with a small lumbar puncture needle (21 to 22 gauge), and is contraindicated in patients with general infections, increased cerebrospinal fluid pressure, or a hemorrhagic tendency (thrombocytopenia or anticoagulant therapy).

Cauda Equina↗