[Abortion technics].
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Biomedical subjects
Publications and source records attributed to S Trotnow.
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Using a standardised questionnaire, 7356 women, patients at the Erlanger Universitäts-Frauenklinik, were interviewed. Women with cervical cancer or carcinoma in situ of the cervix were compared with the remaining patients. Social factors are described which are more frequent with women with cervical cancer than with other women. The more such individual factors are added together, the greater the risk of developing a cervical cancer. Further, social factors are investigated which prevent women from going to prophylactic examinations. The more such factors are encountered, the greater the probability that a woman will not go to prophylactic examinations. Both results were to be expected from common-sense, but until now confirmation by empirical investigation was lacking. The greater the risk of getting cervical cancer, the greater the probability that screening will be avoided. This result show that cervical cancer is to be expected in the greater proportion of about 70% of women over the age of 30 who do not go for prophylactic examination, compared with the 30% who undergo prophylactic examination anually.
Gynecologists prefer the vaginal route for closure of vesicovaginal fistulae. Urologists, however, have some doubts as to the long-term results as far as proper function is concerned. The purpose of this investigation was to discover the limits of the vaginal fistula operations with reference to patients at the Department of Gynecology and Obstetrics, University Erlangen-Nürnberg. From 1962 to 1976, 40 women with vesicovaginal, urethrovaginal and vesicocervicovaginal fistulae were treated. Forty-five operations were necessary. In one patient, surgery in two sessions was planned from the beginning. Besides 4 obstetric fistulae, gynecological operations were the original cause of the fistulae in 34 cases. Two women had actinic fistulae (overdosage of intracavitary radium application). Attempts to close the fistulae here failed utterly. The Latzko technique was used in 27 women. Füth's method, in 7. In the remaining cases various vaginal procedures were chosen, for example, interposition of the bulbocavernosus muscle or interposition of the uterus. Three late complecations with recess formation (in 2 cases with concrements) after the Latzko operation could be treated trans-urethrally. Ten years after a Füth's operation one patient had to undergo vaginal surgery for an urethral diverticulum with concrement. The precedure of choice in the typical post-hysterectomy fistula is the Latzko operation. For fistulae patients who still have a uterus, other vaginal procedures are preferable. No attempt should be made to close a radiogenic fistula--usually following inadequate radiation therapy--by a vaginal operation. Details of our indications are fully dealt with in the discussion.
Breast diseases in 792 women were studied by biopsy and histological evaluation. In all subjects glucose tolerance was examined by OGTT (100 g glucose). The diabetes frequency of 22% in 326 women with breast cancer was compared with the frequency in women with fibroadenoma (n = 101), papilloma (n = 80), fibrocystic disease (n = 107), lipoma, granuloma, fibrosis (n = 88), papilloma with proliferation (n = 32), mastopathy with proliferation (n = 33) and carcinoma in situ lobulare (n = 11). The statistical evaluation was done with an electronic data processing system. We used matched pairs according to age, height and weight. Diabetogenic factors like age and overweight were thus allowed for. These comparative statistics showed a frequency of diabetes twice or three times higher in women with breast cancer. This result cannot be regarded as a consequence of age, overweight and menopause. In groups with fibroadenoma, fibrocystic disease and lipoma, we found glucose tolerance in 1-3%, whereas the group with proliferation (including carcinoma in situ) showed an incidence of 7%. The remarkably high incidence rate of 14% in women with papilloma can be explained by the higher age and the more frequent obesity in this collective.
With a standard questionnaire 7356 lying-in patients at the Department of Obstetrics and Gynecology, University Erlangen-Nürnberg, were asked about their social background and their sexual habits. First of all some statistical facts concerning the frequency of distribution: 20% of all women questioned had their first cohabitation before the age of seventeen. 53% had sexual intercourse with one man, 23% with two, the remainder with more than two men. Quite a number of social characteristics influenced the sexual behavior of women. Thus it was shown that women have their first cohabitation before the age of eighteen the sooner the lower their social status is and the more partners they had. Insufficient contraceptive precautions or the neglect of any contraception were mainly met with women of lower social status. The same correlation could be found between contraceptive behavior on the one hand and the parameters education and strong religious commitment on the other hand. In rural aereas contraceptive measures were used insufficiently or less often then in urban communities.
The relation between the parity of the mother and the birth-weight as well as the size of the new-born child, taking into account the sex, were examined as follows: From the patients needing obstretical care during the period of 1966 to 1971 those 3441 women were chosen who had born twice or more times during this time. By means of an electronic data processing system the weight and size differences of the children were correlated with the parity of the mother taking again into account the order of male and female births. Births with uncertain gestational age, non-cephalic presentations, and premature births were excluded (WHO definition or gestational age less than or equal to 266 days counted from last menstruation). 1. The average birth-weight increases by 105 g from the first to the second child, by 39 g from the second to the third, and by 12 g from the third to the fourth child. Obviously, there is no linear link between the increase of the birth-weight and the increasing parity. The major weight-increase is to be observed from the first to the second child. 2. A corresponding statement concerning the size of the new-born children cannot be made which is partly due to the relative inaccuracy of the method applied. 3. On the average boys weigh between 130 g to 150 g more than girls according to the parity.
In a prospective study at the Department of Obstetrics and Gynecology, University Erlangen-Nürnberg, covering the period from January 1st 1971 til December 31st 1973 the incidence of pathological glucose tolerance was examined in 837 women with breast cancer, benign tumours and conditions requiring excision or air cystography and/or mammography because of suspicion of tumour. The glucose tolerance was tested in all patients by oral ingestion with 100 g glucose of i.v. by means of intravenous injection of 0.33 g glucose/kg body weight. The results in 327 women with breast cancer were compared with those in 510 women with benign breast affections. Using matched pairs, the evaluation was done with an electronic data processing system. Diabetogenic factors like age and body weight were thus allowed for. In the total collective 22.3% out of 327 women with breast cancer were manifestly and 6.7% subclinically diabetic. Our findings allow the following conclusions. 1. Manifest diabetes mellitus is found twice as frequently in women with breast cancer compared to women with benign breast affections. 2. In the collective of pairs matched according to age, height and weight (n = 217) 21% of the women with breast cancer have a pathological glucose tolerance, compared with 10% of the women with benign breast affections. 3. Only 25 out of 73 manifestly diabetic women with breast cancer were aware of their metabolic disorder before admission to hospital, whereas 75% of the diabetic women with benign histological findings did know of it.
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The Latzko operation for the closure of a vesico-vaginal fistula is still not well enough known. Urologists have voiced doubts about the functional quality of the late results after this operation. Pouches in the bladder wall which could lead to infection and stone formation are said to occur frequently. Follow-up studies regarding this question are not known. Therefore the patients treated at the University Hospitals Erlangen-Nuernberg and Graz between 1962 and 1972 were subjected to a standardized follow-up protocol. Of 37 women who had the Latzko operation, 24 women returned for a follow-up examination. 19 women had no intermittent urinary tract disease and the follow-up results were normal. In many instances a scar corresponding to the previous fistula could not be detected on cystoscopy. Immediately after the operation, one patient had a recurrent fistula and has not been re-operated. Four women had significant urinary tract findings or had intermittent urinary tract disease. These complications were possibly due to the operation in one case and likely due to the operation in a second case. Our findings suggests that the Latzko operation is the method of choice for the treatment of the typical post-hysterectomy vesico-vaginal fistula.
Stripping of the membranes for induction of labour is "harmless to mother and infant in contra-distinction to the induction of labour by artifical rupture of the membranes. Our results show that stripping of the membranes has no influence on labour and delivery, on the rate of operative deliveries and on the duration of the third stage of labour. There is no appreciable increase in puerperal morbidity. The Apgar Score remains unchanged. The success rate of stripping of the membranes defined as delivery within 48 hours after stripping of the membranes is related to the state of ripening of the uterine cervix and to the ease with which the membranes can be stripped. These factors should be considered for the indication of stripping of the membranes. The success rate can then be increased. Our overall success rate of induction of labour by stripping of the membranes was 60.8%. The success rate of stripping of the membranes in multiparous women is slightly but not significantly better than in primparous women. The age of the patient has no influence on the success rate.