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Biomedical subjects

S Traccis

Publications and source records attributed to S Traccis.

28 records · Page 2Linked to original sources
PubMed1982

Brain uptake of carbamazepine in the cat.

Carbamazepine (CBZ) was determined by EMIT assay in plasma, cerebrospinal fluid (CSF), and brain samples of cats after administration of the drug (40 mg/kg, i.p.). Plasma and CSF levels increase in a parallel manner from time 0 to 90 min after completion of injection, indicating a passive transport from one body fluid to the other. Brain levels reach a steady state at 15 min, with no significant difference being found between the concentrations at 15, 30, 60, and 90 min postinjection; this indicates that substantial early binding occurs in the brain. Since peak CSF concentrations occur at 90 min, concomitant with those for plasma, while brain levels are already high at 15 min, it is likely that CBZ enters the two compartments by independent mechanisms.

Animals↗
PubMedDate not supplied

Brain distribution of carbamazepine and phenobarbital given in combination in experimental epilepsy.

This study describes the brain distribution of carbamazepine (CBZ) and phenobarbital (PB) given intraperitoneally in combination to cats rendered epileptic by parenteral penicillin and by penicillin topically applied on neocortex. A control group of normal cats was also evaluated pharmacokinetically. Levels of both drugs were extremely low in brains of controls (CBZ 0.8 +/- 0.02 micrograms/g; PB 1.49 +/- 0.7 micrograms/g of fresh tissue), but higher levels were found in brains of epileptic cats with CBZ showing the greater increase (peak concentrations five- to sixfold higher than the corresponding CSF free fraction vs. three- to fourfold higher for PB). This might have been partially due to the ability of CBZ to prevent the metabolic alterations associated with severe convulsions, and hence the binding impairment. As this event had no effect of potentiation on CBZ anticonvulsant activity, the present data confirm previous reports indicating that there is no experimental evidence that two drugs are better than one in controlling epilepsy.

Animals↗
PubMedDate not supplied

POEMS syndrome: a case report.

A case of POEMS syndrome in a 43-year-old male with polyneuropathy, osteolytic lesion of the basin due to solitary IgA-lambda plasmacytoma, cutaneous scleroderma-like changes, diffuse lymphadenopathy and hepatosplenomegaly is described. Liver biopsy showed a regenerative process of the parenchyma without laboratory and histologic evidence of necrosis. A peculiar finding was the onset of a right hemiparesis in the absence of signs of vascular disease or other predisposing factors. The possible links between the peculiar elements of the POEMS syndrome are briefly analyzed and discussed.

Bone Neoplasms↗
PubMedDate not supplied

Diagnostic value of extensor digitorum brevis F-wave in L5 root compression.

The sensibility of F-wave in detecting lumbosacral radicular compression has been found to range from 65% to 18%. The present study was performed on 24 patients suffering from unilateral L5 compressive radiculopathy. The aim was to verify the reliability of extensor digitorum brevis (EDB) F-wave in the diagnosis of L5 root impairment, by using different parameters such as minimal, mean, maximal latency and the difference of these parameters between the affected and unaffected sides. In all patients conventional needle EMG was also performed bilaterally. While the needle EMG showed abnormalities in L5 innervated muscles of all patients, at least one of the different EDB F-wave parameters was found to be abnormal in only 7 patients (29.2%). Moreover no significant relation was observed between the severity of EMG and F-wave abnormalities. We conclude that conventional needle EMG appears to be the most useful electrophysiological technique in the diagnosis of L5 compressive radiculopathy, while EDB F-wave does not provide additional information.

Adult↗
PubMedDate not supplied

[Anticonvulsant action of pargyropyranone in various models of experimental epilepsy in the cat].

The new anticonvulsant drug pargypiranone was studied in different models of experimental epilepsy in cat (penicillin and Premarin cortical focus, cobalt cortical focus, penicillin generalized epilepsy). The drug proved to possess a strong anticonvulsant effect upon focal electroclinical phenomena and a poor effect on penicillin generalized epilepsy. It seems probably that pargypyranone has a valid effect on partial epileptic seizures.

Animals↗