[U loop in idiopathic cardiomyopathy].
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Biomedical subjects
Publications and source records attributed to S Toyama.
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In cases with angina pectoris, the location and configuration of the T loop in a male group and a female group were compared. In the male group, the types of abnormal T loop were mainly an anterior displacement type (the AD type) and an abnormal shape type (the AS type). On the contrary, a posterior displacement type (the PD type) was found in most cases in the female group. The movement of the T loop after exercise test or exacerbation was also different in the two groups. In the male group, an anterior displacement or increase of W/L of the T loop was observed, but in the female group, the T loop was dislocated more to the left and posteriorly. The reason for these differences in the T loop in both groups is discussed.
The authors investigated electrocardiographic changes minutely in five cases of acute pericarditis, and especially in two cases of non-specific pericarditis. The results indicated that the amplitudes of the R and S waves increased progressively immediately after the disease reached a peak, which was reached after abnormal heart shadow in the chest x-ray returned to normal. This increased curve of amplitude varied in association with changes in the ST segment and T wave, suggesting an inflammatory dilatation of the myocardium. On the other hand, however, the curve was indistinct and took a long time to reach a maximum in case of systemic lupus erythematosus pericarditis, and was found to decrease and remain stationary in cases of pericarditis secondary to lung cancer and/or tuberculosis. These facts should become a useful guideline for diagnosis of acute non-specific pericarditis (due to virus origin). Ischemic changes of the ST segment and T wave were manifested by an exercise test during recovery from acute pericarditis when ST segment and T wave abnormalities had already improved and high voltage was the only abnormal finding on the ECG. In the healing stage, regarding the finding of high voltage, it should be pointed out that the myocardium remains as yet with residual damage revealed by loading with exercise, and treatment may be necessary until the abnormal finding has improved.
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In order to investigate the relation between the infarcted area in myocardial infarction and the change of the QRS loop, the following method was tried. The normal QRS loops in 3 planes were constructed with the digital computer. Then the vector of an optional segment corresponding to infarction was diminished and the QRS loops were constructed. The comparison of the QRS loops in clinical cases and in the construction method was made and the vectorcardiographic findings to estimate the infarcted area were discussed.
For confirming the configuration of the QRS loop in left anterior hemiblock, 82 cases with the frontal QRS vector above minus 30 degrees were collected and classified by the configuration of the horizontal QRS loop. Thereafter, a comparison has been made between the configuration of the QRS loop in clinical cases and that in the authors' construction method, and the following findings for criteria of left anterior hemiblock are obtained. 1) The afferent limb of the frontal QRS loop is dislocated to the left and more superiorly. 2) The efferent and afferent limbs of the horizontal QRS loop are located left posteriorly. The configuration of the horizontal QRS loop is long and narrow and the direction of inscription is clockwise, a figure of 8 or counterclockwise. 3) Cases with the right posterosuperior dislocation of the afferent limb of the QRS loop is excluded from left anterior hemiblock.
Expecting activation of myocardial energy liberation, coenzyme Q was applied as a treatment to 55 patients suffering from congestive heart failure. Daily doses of 50 to 100 mg of coenzyme Q7 were injected intravenously in 21 cases for 3 to 35 days. Daily doses of 60 mg of coenzyme Q7 were administered perorally in 17 cases for 14 to 196 days. Daily doses of 30 mg of coenzyme Q10 were administered perorally in 17 cases for 7 to 182 days. Clinical effects were evaluated within 4 weeks by the criteria using a scoring method of severity of congestive heart failure which was devised by the authors. In summary a certain effect was found in 20 cases and a mild effect was observed in 29 cases. No significant changes were observed in heart rate and blood pressure. Exanthema appeared in 2 patients of the group of coenzyme Q7 intravenous injection. In conclusion the therapeutic effect of coenzyme Q was thought to be mild but stable in supplement to digitalis therapy in cases of congestive heart failure.
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