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S Toda

Publications and source records attributed to S Toda.

At least 199 records · Page 11Linked to original sources

Aminoglycoside antibiotics. XII. Effect of N-alkylation in kanamycin antibiotics.

Four N-ethyl derivatives of kanamycin A and five N-ethyl derivatives of kanamycin B were synthesized. The antimicrobial activity of N-ethyl kanamycin derivatives was determined against aminoglycoside-sensitive and resistant organisms. The structure-activity relationship of these compounds is discussed with reference to the activity of N-acyl kanamycin derivatives.

Alkylation↗