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Biomedical subjects

S Tiwari

Publications and source records attributed to S Tiwari.

44 records · Page 3Linked to original sources
PubMedDate not supplied

Chronic bilateral suppurative otitis media caused by Aspergillus terreus.

A case of bilateral suppurative otitis media is described in a patient with the presenting symptoms of otorrhoea, itching, mild deafness, heaviness in the ear and otalgia. The patient had perforation in the tympanic membrane. Histological sections revealed aggregated fungal masses of Aspergillus terreus. The infection responded well to topical ketoconazole therapy. Incidentally, this is the second case from India of chronic suppurative otitis media caused by fungi.

Adult↗
PubMedDate not supplied

COX-inhibitors relieve the immunosuppressive effect of tumor cells and improve functions of immune effectors.

A common phenomenon in cancer patients is a suppressed cell-mediated immunity, characterized by the inability of immune effector cells to mount efficient anti-tumor responses. Immunosuppressive factors, released by the tumor, contribute to this phenomenon and thus to tolerance. Prostaglandins, catalyzed by the cyclooxygenases (COX-1 and COX-2) from arachidonic acid, are one class of these factors. Since at least one of the COX enzymes is often expressed at high level in human cancers, the enzymes were ascribed a causal role in tumor etiology and progression. Non-steroidal antiinflammatory drugs (NSAIDs) like aspirin, which block COX activity, have demonstrated their antitumor effects in preclinical and clinical trials. Pro-apoptotic and anti-angiogenic effects in tumor cells may account for this activity. In addition, by inhibiting the release of prostaglandins from the tumor and by blocking COX activity in immune effector cells, NSAIDs may also bias the function of immune cells towards a more tumoricidal phenotype. We show here that tumor cells inhibit the physiological function of immune cells, and that NSAIDs restore this function. These data contribute to an understanding of the antineoplastic effect ascribed to NSAIDs and support the prophylactic use of these drugs in high-risk patients.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMedDate not supplied

Dermatologic manifestations of lithium: a review.

This paper summarizes the major dermatologic and immunologic complications associated with lithium carbonate ingestion. This drug has demonstrated proven efficacy in the treatment of bipolar affective disorder. This fact, the authors believe, outweights its dermatologic complications, and only exacerbation of psoriasis warrants termination of therapy.

Adolescent↗
PubMedDate not supplied

F-response studies in neonates, infants and children.

F-response has been found to be useful in the evaluation of peripheral nerve conduction in adults and may be especially useful in paediatric nerve conduction studies. In newborns, the nerve conduction velocity is very slow compared to adults because of immaturity of myelination. To assess the effect of age on F-response in 20 neonates, (1 to 28 days), infants (1 mo- 1 y) and children (2-12 y), motor nerve conduction velocity of median, peroneal; sensory conduction velocity of median and F-response from abductor pollicis brevis (APB) by stimulation of median nerve at the wrist were evaluated. The nerve conduction velocity in the neonates was nearly half of that in children and was significantly related to age. F-minimal latency (F-min) showed biphasic distribution; in neonates it was 17 ms, in infants 15 ms and in children 16 ms. The amplitude of F-response was higher compared to infants and children (P less than 0.001). H-reflex in ABP was elicited in all neonates and 55% of infants, its mean latency was 17.9 ms and 15.7 ms respectively. Long latency and high amplitude of F-response and presence of H-reflex in ABP in neonates and infants are due to the immaturity of the nervous system and should be kept in mind while interpreting F-responses in newborns.

Age Factors↗