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Biomedical subjects

S Tinozzi

Publications and source records attributed to S Tinozzi.

At least 19 recordsLinked to original sources
PubMed2005

Oral butyrate for mildly to moderately active Crohn's disease.

BACKGROUND: Butyrate exerts anti-inflammatory effects in experimental colitis and on Crohn's disease lamina propria mononuclear cells in vitro. AIM: To explore the efficacy and safety of oral butyrate in Crohn's disease. METHODS: Thirteen patients with mild-moderate ileocolonic Crohn's disease received 4 g/day butyrate as enteric-coated tablets for 8 weeks. Full colonoscopy and ileoscopy were performed before and after treatment. Endoscopical and histological score, laboratory data, Crohn's disease activity index and mucosal interleukin (IL)-1beta, IL-6, IL-12, interferon-gamma, tumour necrosis factor-alpha and nuclear factor-kappa B (NF-kappaB) were assessed before and after treatment. RESULTS: One patient withdrew from the study, and three patients did not experience clinical improvement. Among the nine patients (69%) who responded to treatment, seven (53%) achieved remission and two had a partial response. Endoscopical and histological score significantly improved after treatment at ileocaecal level (P < 0.05). Leucocyte blood count, erythrocyte sedimentation rate and mucosal levels of NF-kappaB and IL-1beta significantly decreased after treatment (P < 0.05). CONCLUSIONS: Oral butyrate is safe and well tolerated, and may be effective in inducing clinical improvement/remission in Crohn's disease. These data indicate the need for a large investigation to extend the present findings, and suggest that butyrate may exert its action through downregulation of NF-kappaB and IL-1beta.

Administration, Oral↗
PubMed2004

Intestinal perforation as a long-term complication of plug and mesh inguinal hernioplasty: case report.

Tension-free and sutureless hernioplasty by plug and mesh of nonreabsorbable material is one of the most common techniques for inguinal hernia repair. It's a simple and quick procedure with a low cost and allows for a short hospital stay. It shows a low reoccurrence rate, but it can result, in very few cases, in complications strictly related to prosthetic material. The literature describes some cases of plug migration from its proper position, for example, to the scrotum, preperitoneal adipose tissue, and abdominal cavity. We report on a case of sigmoid colon perforation due to a plug of Trabucco hernioplasty performed 2 years previously.

Aged↗
PubMed1992

[Large abdominal incisional hernias, use of prosthesis. Our experience].

Retrospective analysis of risk-factors in 241 patients with large abdominal incisional hernia collected in a 16-year period at the Department of Surgery, University of Pavia, allows the Authors to identify the aetiological mechanism of herniation and to discuss the fundamental technical skills in wall reconstruction. The recurrence rate after primary repair was 30% (63/209 patients). In 32 patients (13.3%) plastic prosthesis was used. The side of recurrent herniation was upper midline in 12 patients (37.5%), lower midline in 6 patients (19%), right lower quadrant in 8 patients (25%), right and left flank in 4 (12.5%) and in 2 patients (6.25%) respectively. Plastic repair was performed with a polytetrafluoroethylene graft (PTFE) in 19 patients (59%), with a polypropylene mesh in 7 patients (22%); woven polyethylene mesh was used in 6 patients (19%). Recurrence after prosthetic repair was seen in 5/32 patients (15.6%) and was correlated to local sepsis in patients with poor nutritional status. The PTFE mesh was considered useful to reduce the recurrence rate of hernias and the postoperative disability. It was associated with good elasticity, adequate strength, satisfactory tissue acceptance and minimal risk of infection. However the best results need a careful preoperative evaluation, no tension on the suture line, the prevention and properly treatment of postoperative complications.

Adult↗
PubMed1989

[Primary malignant neoplasms of the liver. Contribution of echography to the preoperative diagnosis].

Primary malignant hepatic tumors are relatively common and the possibility of radical surgical treatment in the initial stages has modified our clinical approach therefore stressing the validity of a correct screening and follow-up of this pathology. The Authors present their clinical experience in the field enriched by the use of ultrasonography and conclude that this represents a highly effective diagnostic technique whereas it is less reliable in the determination of the nature of the lesion.

Adenoma, Bile Duct↗
PubMed1988

[Postoperative external biliary fistulas: personal case series].

Over the period 1974-1986, five patients with external biliary fistulas were admitted to our clinic. The fistulas set in as complications of surgical operations due in 3 cases to a Kehr drainage of the common bile duct, in 1 case to drainage of a subhepatic abscess and in 1 case to pancreatic hydatid cyst. The causes of onset of the fistulas are reported as well as the therapy adopted in each case.

Biliary Fistula↗
PubMed1987

Efficacy and tolerance of ceftazidime in the treatment of post-operative respiratory tract infections.

Ceftazidime proved particularly effective in the treatment of acute respiratory tract infections arising in the immediate post-operative period, affording complete clinical cures in 88.8% of cases and a substantial improvement in the pathological picture in the other 11.2% of cases treated. The authors also draw attention to the excellent tolerance of the antibiotic, as evaluated on the basis of liver and kidney function and blood chemistry parameters and the total absence of adverse reactions.

Adult↗
PubMed1984

[Controlled clinical study on the efficacy of tiropramide hydrochloride in the treatment of irritable colon: comparison with octylonium bromide].

The effectiveness of a new calmodulin-independent spasmolytic, tiropramide hydrochloride, and octylonium bromide, an antispasmodic calmodulin-antagonist drug, was compared in a controlled trial performed in 60 patients with irritable bowel syndrome with spastic pattern. The effect of treatments was assessed according to the score reduction of following symptoms: abdominal pain, constipation, bloating and dyspepsia. Tiropramide hydrochloride administered at the daily dose of 300 mg for 30 days induced a faster and higher improvement than that observed during the administration of 120 mg daily of octylonium bromide. On 3rd and 5th day, treatment with tiropramide induced the relief of abdominal pain in a significantly greater percentage of patients (p less than 0.05). Besides, in the group of subjects treated with this drug the "pain" score was more markedly decreased. Furthermore, at the end of the study 88% of subjects treated with tiropramide and 47% with octylonium bromide had normal bowel habits. This difference was statistically significant (p less than 0.05). Both treatments are effective in reducing dyspeptic symptoms and bloating. We can conclude that tiropramide--having a significant antispasmodic effect combined with a regulating effect on bowel habits--besides eliminating spasm, would act by synchronizing and therefore normalizing the intestinal motility.

Adult↗
PubMed1983

[Alkaline reflux after gastric resection using the Billroth II method].

Among the more indicative complications encountered in gastrectomized patients, particularly in those cases where the Billroth II technique is used, bile and/or pancreatic reflux is undoubtedly one of the most important manifestations. The abolition of the "sphincteric" function of the pylorus creates a pathophysiological condition of the above-mentioned type when the surgery is not combined with specific antireflux techniques or when particular situations obtain which make alkaline reflux inevitable. These pathophysiological disorders lead to a "chronic gastritis of the stump", which often exhibits differing symptomatic pictures. There are patients in whom there is no correspondence between the anatomo-pathological and symptomatic pictures and who do not suffer at all, phereas there are others (5-35%) who complain of severe symptoms such as epigastric pain aggravated by ingestion of food, reduction in weight, nausea, bile vomiting and often haemorrhagic stillicide with consequent sideropaenic hypochromic anaemia. Taking the above-mentioned considerations as their starting point, the authors set out to investigate these complications more thoroughly in the pathology of gastrectomized patients by means of the long-term follow-up of such patients coming to them for observation after having been subjected to surgical therapy in the form of Billroth II gastric resection (gastro-enterostomy according to Balfour-Kroenlein, or according to Hofmeister-Fininsterer). The study, which is currently still in progress, involves a thorough clinical examination of the symptoms complained of as well as radiological, gastroscopic, histological and haematochemical investigations. The authors report on their preliminary results.

Acid-Base Equilibrium↗
PubMed1981

[Experimental and clinical study of the use of an adhesive (Histoacryl-Blau) in intestinal anastomoses].

Postoperative integrity of anastomoses in abdominal surgery is fundamental to secure a good result in reconstruction operations which involve the resection of several parts of the alimentary tract where afflicted by various pathologies. The Authors study this problem with an experimental work. These experiments illustrate the resistance of STPU stapler sutures and their capability to overcome pressures which are above physiological level; the application of histoacryl glue strengthens even more the sutured area increasing the level of pressure resistance. This procedure allows the patient to drink sooner and avoids the perforation of stomata which means a reduction of the patient's discomfort and a reduction of his confinement to bed.

Animals↗
PubMed1980

[Etiopathogenetic, diagnostic and clinical considerations on simultaneous bilateral carcinomas of the breast. II].

In the first note the Authors have described five cases of bilateral simultaneous breast carcinoma. Now they shortly describe some opinions about the problems of the genetic independence between the two diseases. They draw attention about the histologic diagnosis and the identification of diseases underestimated and now explained as carcinoma "in situ" potentially fit for transformation in infiltrating cancer. For this reason it's important and justifiable to have the patients with cancer of the breast, a series of clinical research as well as mammography thermography and biopsy of controlateral breast in order to ascertain the presence of carcinoma "in situ" that could justify the prophylactic mastectomy.

Adult↗
PubMed1980

[Surgical treatment of gastric cancer. New experimental reconstructive technic after total gastrectomy].

The Authors deal the always present problem of a proper reconstruction of the digestive tract after total gastrectomy operations for gastric cancer. The Authors, then, describe a experimental operation, after having dealth with the considerations concerning the symptomatic consequences that usual different kind of operations cause upon patients. That operation has been experimented upon animals, and consists in a neo-stomach. In this reconstruction they interpose a tract of jejunum loop between oesophagus and duodenum. The jejunum loop must be lengthwise dissected, twisted and sutured in such away as to obtain a new structure that will be last anatomically similar to a stomach. The Authors hope that this new technique might be successfully applied upon man sometime in the future.

Animals↗